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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of spindle checkpoint
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Accession:GO:0090231 term browser browse the term
Definition:Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
Comment:Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).


show annotations for term's descendants           Sort by:
deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mad1l1 MAD1 mitotic arrest deficient 1-like 1 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 5:139,994,444...140,307,346
Ensembl chr 5:139,994,444...140,307,307 		JBrowse link
G Mad2l1bp MAD2L1 binding protein involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr17:46,458,311...46,464,477
Ensembl chr17:46,458,313...46,464,479 		JBrowse link
G Prap1 proline-rich acidic protein 1 involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr 7:139,673,309...139,677,116
Ensembl chr 7:139,673,308...139,677,113 		JBrowse link
negative regulation of mitotic spindle assembly checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ska1 spindle and kinetochore associated complex subunit 1 involved_in ISS UniProt GO_REF:0000024 NCBI chr18:74,328,370...74,340,889
Ensembl chr18:74,328,370...74,340,889 		JBrowse link
G Ska3 spindle and kinetochore associated complex subunit 3 involved_in ISS UniProt GO_REF:0000024 NCBI chr14:58,044,016...58,063,748
Ensembl chr14:58,044,018...58,063,642 		JBrowse link
positive regulation of meiosis I spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Knl1 kinetochore scaffold 1 involved_in IMP (PMID:35167144) UniProt PMID:35167144 NCBI chr 2:118,877,600...118,940,978
Ensembl chr 2:118,877,600...118,935,982 		JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurkb aurora kinase B involved_in NAS (PMID:17956729) ComplexPortal PMID:17956729 NCBI chr11:68,936,477...68,942,490
Ensembl chr11:68,936,473...68,942,490 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 involved_in NAS (PMID:17956729) ComplexPortal PMID:17956729 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569 		JBrowse link
G Cdca8 cell division cycle associated 8 involved_in NAS (PMID:17956729) ComplexPortal PMID:17956729 NCBI chr 4:124,812,258...124,830,710
Ensembl chr 4:124,812,258...124,833,104 		JBrowse link
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr 9:114,517,899...114,552,856
Ensembl chr 9:114,517,858...114,553,370 		JBrowse link
G Gen1 GEN1, Holliday junction 5' flap endonuclease involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr12:11,288,929...11,316,030
Ensembl chr12:11,288,921...11,315,802 		JBrowse link
G Incenp inner centromere protein involved_in NAS (PMID:17956729) ComplexPortal PMID:17956729 NCBI chr19:9,849,659...9,876,853
Ensembl chr19:9,849,660...9,876,915 		JBrowse link
G Mad1l1 MAD1 mitotic arrest deficient 1-like 1 involved_in ISO
ISS		 GO_Central
UniProt
ComplexPortal		 GO_REF:0000024 GO_REF:0000114 GO_REF:0000119 NCBI chr 5:139,994,444...140,307,346
Ensembl chr 5:139,994,444...140,307,307 		JBrowse link
G Mad2l1 MAD2 mitotic arrest deficient-like 1 involved_in IMP
ISO		 (PMID:20870947) UniProt
GO_Central
ComplexPortal		 PMID:20870947 GO_REF:0000114 GO_REF:0000119 NCBI chr 6:66,512,205...66,518,091
Ensembl chr 6:66,512,374...66,524,204 		JBrowse link
G Ndc80 NDC80 kinetochore complex component involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr17:71,803,095...71,833,852
Ensembl chr17:71,803,095...71,833,852 		JBrowse link
G Pcid2 PCI domain containing 2 involved_in IMP
ISO		 (PMID:20870947) UniProt
GO_Central		 PMID:20870947 GO_REF:0000119 NCBI chr 8:13,125,476...13,155,343
Ensembl chr 8:13,127,189...13,155,459 		JBrowse link
G Tpr translocated promoter region, nuclear basket protein involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr 1:150,268,544...150,325,686
Ensembl chr 1:150,268,589...150,325,686 		JBrowse link
G Xrcc3 X-ray repair complementing defective repair in Chinese hamster cells 3 involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr12:111,769,626...111,780,326
Ensembl chr12:111,769,626...111,780,307 		JBrowse link
regulation of meiosis I spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zwint ZW10 interactor involved_in IMP (PMID:26486467) UniProt PMID:26486467 NCBI chr10:72,490,678...72,510,796
Ensembl chr10:72,490,677...72,510,796 		JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc15 anaphase promoting complex C subunit 15 involved_in IBA
ISS
ISO		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr 7:101,530,508...101,551,056
Ensembl chr 7:101,512,922...101,551,056 		JBrowse link
G Anapc15-ps anaphase promoting complex C subunit 15, pseudogene involved_in IBA
ISO		 GO_Central GO_REF:0000033 GO_REF:0000119 NCBI chr10:95,508,550...95,509,377
Ensembl chr10:95,508,853...95,509,251 		JBrowse link
G Ccnb1 cyclin B1 involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Ccnb1-ps cyclin B1, pseudogene involved_in ISO GO_Central GO_REF:0000119 NCBI chr 7:41,755,193...41,756,726
Ensembl chr 7:41,755,323...41,756,609 		JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 involved_in IBA
ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr 4:70,135,092...70,328,672
Ensembl chr 4:70,135,093...70,328,680 		JBrowse link
G Dusp1 dual specificity phosphatase 1 involved_in ISS UniProt GO_REF:0000024 NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102 		JBrowse link
G Knl1 kinetochore scaffold 1 involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr 2:118,877,600...118,940,978
Ensembl chr 2:118,877,600...118,935,982 		JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI
GO_Central		 GO_REF:0000008 GO_REF:0000033 NCBI chr 7:122,977,026...123,029,581
Ensembl chr 7:122,969,007...123,029,581 		JBrowse link
G Prpf4b pre-mRNA processing factor 4B involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr13:35,058,803...35,090,047
Ensembl chr13:35,059,285...35,090,047 		JBrowse link
G Usp44 ubiquitin specific peptidase 44 involved_in IDA (PMID:21853124) UniProt PMID:21853124 NCBI chr10:93,655,831...93,696,792
Ensembl chr10:93,667,417...93,693,950 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28635
    cellular process 18392
      signal transduction 6924
        intracellular signal transduction 3214
          cell cycle checkpoint signaling 199
            spindle checkpoint signaling 54
              regulation of spindle checkpoint 27
                negative regulation of spindle checkpoint + 5
                positive regulation of spindle checkpoint + 13
                regulation of meiosis I spindle assembly checkpoint + 2
                regulation of mitotic spindle checkpoint + 26
Path 2
Term Annotations click to browse term
  biological_process 28635
    biological regulation 13450
      regulation of biological process 13009
        regulation of cellular process 12632
          regulation of cell cycle 1152
            regulation of cell cycle process 817
              negative regulation of cell cycle process 344
                negative regulation of cell cycle phase transition 290
                  cell cycle checkpoint signaling 199
                    spindle checkpoint signaling 54
                      regulation of spindle checkpoint 27
                        negative regulation of spindle checkpoint + 5
                        positive regulation of spindle checkpoint + 13
                        regulation of meiosis I spindle assembly checkpoint + 2
                        regulation of mitotic spindle checkpoint + 26
paths to the root