Pcid2 (PCI domain containing 2) - Rat Genome Database

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Gene: Pcid2 (PCI domain containing 2) Mus musculus
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Symbol: Pcid2
Name: PCI domain containing 2
RGD ID: 1316002
MGI Page MGI
Description: Predicted to enable RNA binding activity and double-stranded DNA binding activity. Involved in several processes, including positive regulation of mitotic cell cycle spindle assembly checkpoint; regulation of DNA-templated transcription; and spleen development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of nuclear pore nuclear basket and transcription export complex 2. Is expressed in lung; nervous system; retina layer; and skeletal muscle. Orthologous to human PCID2 (PCI domain containing 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A730042J05Rik; CSN12-like protein; PCI domain-containing protein 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39813,125,476 - 13,155,343 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl813,127,189 - 13,155,459 (-)EnsemblGRCm39 Ensembl
GRCm38813,075,476 - 13,105,343 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl813,077,189 - 13,105,459 (-)EnsemblGRCm38mm10GRCm38
MGSCv37813,077,525 - 13,105,343 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36813,077,167 - 13,105,382 (-)NCBIMGSCv36mm8
Celera813,244,463 - 13,272,258 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map85.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12077329   PMID:12393421   PMID:12477932   PMID:15226823   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:16467204   PMID:17616641   PMID:18287559   PMID:18339895   PMID:19481525   PMID:20870947   PMID:21677750   PMID:21873635   PMID:24167073   PMID:28378742   PMID:29138493  
PMID:30196744   PMID:32325033   PMID:34255829   PMID:36114006  


Genomics

Comparative Map Data
Pcid2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39813,125,476 - 13,155,343 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl813,127,189 - 13,155,459 (-)EnsemblGRCm39 Ensembl
GRCm38813,075,476 - 13,105,343 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl813,077,189 - 13,105,459 (-)EnsemblGRCm38mm10GRCm38
MGSCv37813,077,525 - 13,105,343 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36813,077,167 - 13,105,382 (-)NCBIMGSCv36mm8
Celera813,244,463 - 13,272,258 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map85.73NCBI
PCID2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813113,165,002 - 113,208,669 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13113,177,536 - 113,208,715 (-)EnsemblGRCh38hg38GRCh38
GRCh3713113,831,850 - 113,862,983 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613112,879,927 - 112,910,984 (-)NCBINCBI36Build 36hg18NCBI36
Celera1394,658,168 - 94,689,275 (-)NCBICelera
Cytogenetic Map13q34NCBI
HuRef1394,270,740 - 94,301,913 (-)NCBIHuRef
CHM1_113113,800,717 - 113,831,888 (-)NCBICHM1_1
T2T-CHM13v2.013112,427,103 - 112,461,015 (-)NCBIT2T-CHM13v2.0
Pcid2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81683,125,386 - 83,150,851 (+)NCBIGRCr8
mRatBN7.21676,423,245 - 76,448,712 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1676,423,245 - 76,448,712 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1681,703,795 - 81,729,260 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01685,156,372 - 85,181,837 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01680,405,044 - 80,431,334 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01681,757,582 - 81,783,047 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1681,756,971 - 81,783,047 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01681,242,949 - 81,268,414 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41681,280,427 - 81,305,892 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11681,279,932 - 81,305,288 (+)NCBI
Celera1674,229,279 - 74,254,744 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
Pcid2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955404618,092 - 639,704 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955404618,092 - 639,424 (+)NCBIChiLan1.0ChiLan1.0
PCID2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214114,681,970 - 114,713,034 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113113,369,041 - 113,400,323 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01394,319,699 - 94,350,763 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113113,388,251 - 113,419,523 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13113,388,251 - 113,419,251 (-)Ensemblpanpan1.1panPan2
PCID2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12260,602,440 - 60,623,811 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2260,602,888 - 60,623,719 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2260,314,829 - 60,336,177 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02261,228,565 - 61,250,676 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2261,228,122 - 61,309,216 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12260,726,462 - 60,747,819 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02260,728,651 - 60,750,011 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02260,760,103 - 60,781,453 (-)NCBIUU_Cfam_GSD_1.0
Pcid2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945195,488,082 - 195,511,764 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936472446,712 - 465,039 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936472440,440 - 464,116 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCID2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1178,541,318 - 78,556,733 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11178,541,278 - 78,556,784 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21186,178,780 - 86,194,261 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCID2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1391,163,158 - 91,212,450 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl391,177,463 - 91,211,735 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604648,212,929 - 48,249,687 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcid2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624793722,762 - 744,743 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624793722,743 - 744,824 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pcid2
959 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1852
Count of miRNA genes:667
Interacting mature miRNAs:817
Transcripts:ENSMUST00000164416, ENSMUST00000165097, ENSMUST00000166881, ENSMUST00000167198, ENSMUST00000168164, ENSMUST00000172443
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357525Pnhdlc3_mplasma non-HDL cholesterol 3 (mouse)Not determined8721249923753815Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124751082Mouse
14697703Stsl1_mSalmonella typhimurium susceptibility locus 1 (mouse)81135000017050016Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8495000035067154Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8721249935110107Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000164416   ⟹   ENSMUSP00000133204
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl813,127,189 - 13,155,459 (-)Ensembl
GRCm38.p6 Ensembl813,077,189 - 13,105,459 (-)Ensembl
Ensembl Acc Id: ENSMUST00000165097
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl813,129,724 - 13,136,683 (-)Ensembl
GRCm38.p6 Ensembl813,079,724 - 13,086,683 (-)Ensembl
Ensembl Acc Id: ENSMUST00000166881
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl813,129,896 - 13,154,831 (-)Ensembl
GRCm38.p6 Ensembl813,079,896 - 13,104,831 (-)Ensembl
Ensembl Acc Id: ENSMUST00000167198   ⟹   ENSMUSP00000130059
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl813,135,325 - 13,148,607 (-)Ensembl
GRCm38.p6 Ensembl813,085,325 - 13,098,607 (-)Ensembl
Ensembl Acc Id: ENSMUST00000168164   ⟹   ENSMUSP00000128207
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl813,127,189 - 13,155,459 (-)Ensembl
GRCm38.p6 Ensembl813,077,189 - 13,105,459 (-)Ensembl
Ensembl Acc Id: ENSMUST00000172443   ⟹   ENSMUSP00000127622
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl813,135,374 - 13,154,821 (-)Ensembl
GRCm38.p6 Ensembl813,085,374 - 13,104,821 (-)Ensembl
RefSeq Acc Id: NM_178708   ⟹   NP_848823
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39813,127,525 - 13,155,343 (-)NCBI
GRCm38813,077,525 - 13,105,343 (-)NCBI
MGSCv37813,077,525 - 13,105,343 (-)RGD
Celera813,244,463 - 13,272,258 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006508761   ⟹   XP_006508824
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39813,125,476 - 13,140,164 (-)NCBI
GRCm38813,075,476 - 13,090,102 (-)NCBI
Sequence:
RefSeq Acc Id: NP_848823   ⟸   NM_178708
- UniProtKB: Q147Z6 (UniProtKB/Swiss-Prot),   Q8C951 (UniProtKB/Swiss-Prot),   Q8BFV2 (UniProtKB/Swiss-Prot),   A0JLQ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006508824   ⟸   XM_006508761
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000133204   ⟸   ENSMUST00000164416
Ensembl Acc Id: ENSMUSP00000127622   ⟸   ENSMUST00000172443
Ensembl Acc Id: ENSMUSP00000128207   ⟸   ENSMUST00000168164
Ensembl Acc Id: ENSMUSP00000130059   ⟸   ENSMUST00000167198
Protein Domains
PCI

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BFV2-F1-model_v2 AlphaFold Q8BFV2 1-399 view protein structure

Promoters
RGD ID:6843586
Promoter ID:MM_KWN:53681
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000046904,   ENSMUST00000121426,   NM_178708,   OTTMUST00000076734,   OTTMUST00000076736,   OTTMUST00000076769
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36813,104,701 - 13,106,112 (-)MPROMDB
RGD ID:8666477
Promoter ID:EPDNEW_M11270
Type:multiple initiation site
Name:Pcid2_1
Description:Mus musculus PCI domain containing 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11271  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38813,104,833 - 13,104,893EPDNEW
RGD ID:8666481
Promoter ID:EPDNEW_M11271
Type:multiple initiation site
Name:Pcid2_2
Description:Mus musculus PCI domain containing 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11270  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38813,105,360 - 13,105,420EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2443003 AgrOrtholog
Ensembl Genes ENSMUSG00000038542 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000164416 ENTREZGENE
  ENSMUST00000164416.8 UniProtKB/Swiss-Prot
  ENSMUST00000167198.2 UniProtKB/TrEMBL
  ENSMUST00000168164.8 UniProtKB/TrEMBL
  ENSMUST00000172443.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Csn12-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PCI_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:234069 UniProtKB/Swiss-Prot
MGD MGI:2443003 ENTREZGENE
NCBI Gene 234069 ENTREZGENE
PANTHER PCI DOMAIN-CONTAINING PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12732 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PCI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pcid2 PhenoGen
PROSITE PCI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0JLQ7 ENTREZGENE, UniProtKB/TrEMBL
  E9Q1H5_MOUSE UniProtKB/TrEMBL
  E9Q5V9_MOUSE UniProtKB/TrEMBL
  F6QZZ3_MOUSE UniProtKB/TrEMBL
  PCID2_MOUSE UniProtKB/Swiss-Prot
  Q147Z6 ENTREZGENE
  Q8BFV2 ENTREZGENE
  Q8BNM3_MOUSE UniProtKB/TrEMBL
  Q8C951 ENTREZGENE
UniProt Secondary Q147Z6 UniProtKB/Swiss-Prot
  Q8C951 UniProtKB/Swiss-Prot