Prap1 (proline-rich acidic protein 1) - Rat Genome Database

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Gene: Prap1 (proline-rich acidic protein 1) Mus musculus
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Symbol: Prap1
Name: proline-rich acidic protein 1
RGD ID: 1332324
MGI Page MGI
Description: Enables triglyceride binding activity. Involved in cellular response to X-ray and negative regulation of apoptotic process. Acts upstream of or within positive regulation of intestinal lipid absorption; positive regulation of phospholipid transport; and positive regulation of triglyceride transport. Located in endoplasmic reticulum and extracellular region. Is expressed in several structures, including female reproductive system; intestine; and lower jaw. Orthologous to human PRAP1 (proline rich acidic protein 1); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: pregnancy-specific uterine protein; U; Upa; uterine-specific proline-rich acidic protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397139,673,309 - 139,677,116 (+)NCBIGRCm39mm39
GRCm39 Ensembl7139,673,308 - 139,677,113 (+)Ensembl
GRCm387140,093,396 - 140,097,203 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7140,093,395 - 140,097,200 (+)EnsemblGRCm38mm10GRCm38
MGSCv377147,279,295 - 147,283,102 (+)NCBIGRCm37mm9NCBIm37
MGSCv367139,944,718 - 139,948,517 (+)NCBImm8
Celera7139,891,394 - 139,895,266 (+)NCBICelera
Cytogenetic Map7F4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:9065197   PMID:10022836   PMID:10899595   PMID:12466851   PMID:12477932   PMID:15060137   PMID:15604097   PMID:16602821   PMID:20547205   PMID:20562862   PMID:20674898   PMID:21267068  
PMID:21677750   PMID:21858045   PMID:32629119   PMID:33168624  


Genomics

Comparative Map Data
Prap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397139,673,309 - 139,677,116 (+)NCBIGRCm39mm39
GRCm39 Ensembl7139,673,308 - 139,677,113 (+)Ensembl
GRCm387140,093,396 - 140,097,203 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7140,093,395 - 140,097,200 (+)EnsemblGRCm38mm10GRCm38
MGSCv377147,279,295 - 147,283,102 (+)NCBIGRCm37mm9NCBIm37
MGSCv367139,944,718 - 139,948,517 (+)NCBImm8
Celera7139,891,394 - 139,895,266 (+)NCBICelera
Cytogenetic Map7F4NCBI
PRAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10133,347,368 - 133,352,683 (+)EnsemblGRCh38hg38GRCh38
GRCh3810133,347,373 - 133,352,683 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710135,160,877 - 135,166,187 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610135,010,901 - 135,016,177 (+)NCBINCBI36hg18NCBI36
Build 3410135,049,791 - 135,055,068NCBI
Celera10128,351,341 - 128,356,680 (-)NCBI
Cytogenetic Map10q26.3NCBI
HuRef10128,704,994 - 128,710,302 (+)NCBIHuRef
CHM1_110135,442,819 - 135,448,127 (+)NCBICHM1_1
Prap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21194,883,078 - 194,886,874 (+)NCBI
Rnor_6.0 Ensembl1212,558,257 - 212,562,051 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01212,558,257 - 212,562,053 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01219,472,906 - 219,476,702 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41199,889,629 - 199,893,425 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11200,039,620 - 200,043,415 (+)NCBI
Celera1192,560,142 - 192,563,938 (+)NCBICelera
Cytogenetic Map1q41NCBI
Prap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495547710,982,530 - 11,002,747 (+)NCBIChiLan1.0ChiLan1.0
PRAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110134,248,728 - 134,268,442 (+)NCBIpanpan1.1PanPan1.1panPan2
PRAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12840,927,744 - 40,931,355 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2840,982,768 - 40,986,442 (+)NCBI
ROS_Cfam_1.02841,562,642 - 41,566,316 (+)NCBI
UMICH_Zoey_3.12841,046,731 - 41,050,405 (+)NCBI
UNSW_CanFamBas_1.02841,036,325 - 41,039,999 (+)NCBI
UU_Cfam_GSD_1.02841,439,226 - 41,442,900 (+)NCBI
Prap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244072136,080,911 - 6,090,531 (-)NCBI
SpeTri2.0NW_00493648619,477,278 - 19,480,387 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.114141,325,965 - 141,329,955 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214153,794,810 - 153,798,712 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12653,195,600 - 53,201,846 (+)NCBI
Vero_WHO_p1.0NW_02366605441,331,491 - 41,337,643 (+)NCBI
Prap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473713,346,621 - 13,350,428 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753600000143600000Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773500000143600000Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7110108163144108163Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7110108163144108163Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7110108163144108163Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7111365511145365612Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7111365511145365612Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111564398145441459Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111564398145441459Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111564398145441459Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112950524145441459Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7113321003145441459Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7117032360145441459Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7119094158144844577Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119530844145441459Mouse
13207594Nigsq1_mneuroglucopenia-induced glucagon secretion QTL 1 (mouse)7127436844145441459Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127757504145441459Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127844414145441459Mouse
14746988Manh63_mmandible shape 63 (mouse)7128181700145441459Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:152
Count of miRNA genes:148
Interacting mature miRNAs:152
Transcripts:ENSMUST00000026540
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000026540   ⟹   ENSMUSP00000026540
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7140,093,395 - 140,097,200 (+)Ensembl
RefSeq Acc Id: NM_009475   ⟹   NP_033501
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397139,673,309 - 139,677,116 (+)NCBI
GRCm387140,093,396 - 140,097,203 (+)ENTREZGENE
MGSCv377147,279,295 - 147,283,102 (+)RGD
Celera7139,891,394 - 139,895,266 (+)RGD
cM Map7 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_033501 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC24897 (Get FASTA)   NCBI Sequence Viewer  
  AAH51092 (Get FASTA)   NCBI Sequence Viewer  
  EDL17907 (Get FASTA)   NCBI Sequence Viewer  
  EDL17908 (Get FASTA)   NCBI Sequence Viewer  
  Q80XD8 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_033501   ⟸   NM_009475
- Peptide Label: precursor
- UniProtKB: Q80XD8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000026540   ⟸   ENSMUST00000026540

Promoters
RGD ID:8665995
Promoter ID:EPDNEW_M11029
Type:initiation region
Name:Prap1_1
Description:Mus musculus proline-rich acidic protein 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387140,093,395 - 140,093,455EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:893573 AgrOrtholog
Ensembl Genes ENSMUSG00000025467 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000026540 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000026540 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro PRAP UniProtKB/Swiss-Prot
KEGG Report mmu:22264 UniProtKB/Swiss-Prot
MGD MGI:893573 ENTREZGENE
NCBI Gene 22264 ENTREZGENE
PANTHER PTHR37861 UniProtKB/Swiss-Prot
Pfam PRAP UniProtKB/Swiss-Prot
PhenoGen Prap1 PhenoGen
UniProt PRAP1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q60874 UniProtKB/Swiss-Prot