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Gene: Knl1 (kinetochore scaffold 1) Mus musculus
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Symbol: Knl1
Name: kinetochore scaffold 1
Description: Predicted to be involved in attachment of spindle microtubules to kinetochore; negative regulation of phosphatase activity; and protein localization to kinetochore. Predicted to localize to the acrosomal vesicle; condensed chromosome kinetochore; and nuclear body. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly and primary autosomal recessive microcephaly 4. Is expressed in telencephalon ventricular layer. Orthologous to human KNL1 (kinetochore scaffold 1); INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2310043D08Rik; 5730505K17Rik; cancer susceptibility candidate 5; cancer susceptibility candidate gene 5 protein homolog; Casc5; kinetochore-null protein 1; MGC91208
Orthologs:
Homo sapiens (human) : KNL1 (kinetochore scaffold 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Knl1 (kinetochore scaffold 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Knl1 (kinetochore scaffold 1)
Pan paniscus (bonobo/pygmy chimpanzee) : KNL1 (kinetochore scaffold 1)
Canis lupus familiaris (dog) : KNL1 (kinetochore scaffold 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Knl1 (kinetochore scaffold 1)
Sus scrofa (pig) : KNL1 (kinetochore scaffold 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl2119,047,119 - 119,105,501 (+)Ensembl
GRCm382119,047,119 - 119,110,497 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372118,872,855 - 118,929,857 (+)NCBIGRCm37mm9NCBIm37
MGSCv362119,993,968 - 120,051,070 (+)NCBImm8
MGSCv362118,738,474 - 118,795,562 (+)NCBImm8
Celera2120,199,115 - 120,256,832 (+)NCBICelera
Cytogenetic Map2 E5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Knl1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1615801
Created: 2007-04-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.