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ONTOLOGY REPORT - ANNOTATIONS

Term:cell cycle checkpoint signaling
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Accession:GO:0000075 term browser browse the term
Definition:A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction.
Comment:This term should not be used in direct manual annotation as it should always be possible to minimally designate mitotic or meiotic checkpoint, and usually to additionally specify the checkpoint (i.e mitotic spindle assembly checkpoint, mitotic DNA damage checkpoint etc). Note also that the effector processes are not part of the checkpoint but are positively regulated by the checkpoint signaling and should not be annotated here.
Synonyms:exact_synonym: cell cycle checkpoint;   signal transduction involved in G2/M transition checkpoint;   signal transduction involved in cell cycle checkpoint
 narrow_synonym: G1/S checkpoint;   G1/S transition checkpoint;   G2/M checkpoint;   G2/M transition checkpoint
 alt_id: GO:0031576;   GO:0071779;   GO:0072395;   GO:0072404;   GO:0072407
 xref: Wikipedia:Cell_cycle_checkpoint


show annotations for term's descendants           Sort by:
 
deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 involved_in ISO (PMID:22581055) RGD PMID:22581055 NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659 		JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in ISO (PMID:19010891) RGD PMID:19010891 NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703 		JBrowse link
G Mad2l1bp MAD2L1 binding protein involved_in ISO (PMID:18022368) RGD PMID:18022368 NCBI chr 9:14,832,133...14,836,458
Ensembl chr 9:14,832,132...14,837,447 		JBrowse link
G Prap1 proline-rich acidic protein 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:24374861)		 UniProt
RGD		 PMID:24374861 GO_REF:0000024 NCBI chr 1:194,883,078...194,886,874
Ensembl chr 1:194,883,078...194,886,872 		JBrowse link
DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:2679752|PMID:12937170)		 RGD PMID:12937170 PMID:21873635 MGI:2679752, RGD:13792537 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atr ATR serine/threonine kinase involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:2679752|PMID:12937170)
(PMID:14657349)		 RGD PMID:12937170 PMID:14657349 PMID:21873635 MGI:2679752, RGD:13792537 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136 		JBrowse link
G Atrip ATR interacting protein involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:109,708,440...109,722,511
Ensembl chr 8:109,708,440...109,722,477 		JBrowse link
G Cdc5l cell division cycle 5-like involved_in ISS
ISO		 GO_REF:0000024
(PMID:24332808)		 UniProt
RGD		 PMID:24332808 GO_REF:0000024 NCBI chr 9:15,564,949...15,603,453
Ensembl chr 9:15,564,767...15,603,450 		JBrowse link
G Cep63 centrosomal protein 63 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 8:103,162,639...103,214,177
Ensembl chr 8:103,162,700...103,214,177 		JBrowse link
G Chek1 checkpoint kinase 1 involved_in
acts_upstream_of_or_within		 ISO
ISS		 (PMID:16963448), (PMID:19716789)
MGI:1926528 (MGI:1860049|PMID:10859164), (MGI:2449744|PMID:12529385)
GO_REF:0000024		 RGD
UniProt		 PMID:10859164 PMID:12529385 PMID:16963448 PMID:19716789 GO_REF:0000024 MGI:1860049 MGI:2449744 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Chek2 checkpoint kinase 2 IMP RGD PMID:10435585 RGD:633752 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Clock clock circadian regulator involved_in ISO
IEA		 (PMID:21659603)
GO_REF:0000107		 RGD
Ensembl		 PMID:21659603 GO_REF:0000107 NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400 		JBrowse link
G Clspn claspin involved_in ISO (PMID:16963448) RGD PMID:16963448 NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034 		JBrowse link
G Donson DNA replication fork stabilization factor DONSON involved_in ISO (PMID:28191891) RGD PMID:28191891 NCBI chr11:30,911,616...30,933,150
Ensembl chr11:30,923,239...30,932,889 		JBrowse link
G Dot1l DOT1 like histone lysine methyltransferase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:8,917,786...8,959,474
Ensembl chr 7:8,917,786...8,956,475 		JBrowse link
G E2f1 E2F transcription factor 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:12717439)		 UniProt
RGD		 PMID:12717439 GO_REF:0000024 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:105,356,261...105,441,630
Ensembl chr 3:105,356,261...105,441,630 		JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor involved_in ISO (PMID:25820262) RGD PMID:25820262 NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587 		JBrowse link
G H2ax H2A.X variant histone involved_in
NOT|acts_upstream_of_or_within		 ISO (PMID:17974976)
MGI:2156048 (MGI:2179182|PMID:11934988)		 RGD PMID:11934988 PMID:17974976 MGI:2179182 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hinfp histone H4 transcription factor involved_in ISO (PMID:17974976) RGD PMID:17974976 NCBI chr 8:44,634,333...44,644,288
Ensembl chr 8:44,634,333...44,641,000 		JBrowse link
G Hus1 HUS1 checkpoint clamp component involved_in
acts_upstream_of_or_within		 ISO (PMID:21659603)
MGI:1927769 (MGI:2449744|PMID:12529385)		 RGD PMID:12529385 PMID:21659603 MGI:2449744 NCBI chr14:83,688,702...83,703,466
Ensembl chr14:83,688,708...83,703,442 		JBrowse link
G Ints7 integrator complex subunit 7 involved_in ISO (PMID:21659603) RGD PMID:21659603 NCBI chr13:103,155,123...103,207,953
Ensembl chr13:103,155,090...103,208,592 		JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 involved_in ISO (PMID:11836244) RGD PMID:11836244 NCBI chr 3:57,128,561...57,289,943
Ensembl chr 3:57,130,551...57,289,626 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:2679752|PMID:12937170)		 Ensembl
RGD		 PMID:12937170 GO_REF:0000107 MGI:2679752 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Nbn nibrin acts_upstream_of_or_within ISO (PMID:12529385) RGD PMID:12529385 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150 		JBrowse link
G Prpf19 pre-mRNA processing factor 19 involved_in ISS
ISO		 GO_REF:0000024
(PMID:24332808)		 UniProt
RGD		 PMID:24332808 GO_REF:0000024 NCBI chr 1:207,541,582...207,552,664
Ensembl chr 1:207,541,595...207,552,662 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 acts_upstream_of_or_within ISO MGI:2176524 (MGI:2679752|PMID:12937170) RGD PMID:12937170 MGI:2679752 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Rad1 RAD1 checkpoint DNA exonuclease involved_in ISO
IBA		 (PMID:21659603)
PMID:21873635		 RGD PMID:21659603 PMID:21873635 RGD:13792537 NCBI chr 2:59,461,597...59,469,707
Ensembl chr 2:59,461,607...59,469,689 		JBrowse link
G Rad17 RAD17 checkpoint clamp loader component involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:31,764,260...31,794,542
Ensembl chr 2:31,764,261...31,794,072 		JBrowse link
G Rad9a RAD9 checkpoint clamp component A involved_in ISO (PMID:21659603) RGD PMID:21659603 NCBI chr 1:201,488,511...201,553,582
Ensembl chr 1:201,487,136...201,553,608 		JBrowse link
G Rhno1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 involved_in ISO
IBA		 (PMID:21659603)
PMID:21873635		 RGD PMID:21659603 PMID:21873635 RGD:13792537 NCBI chr 4:161,634,047...161,639,437
Ensembl chr 4:161,634,048...161,639,371 		JBrowse link
G Tipin timeless interacting protein acts_upstream_of_or_within ISO (MGI:3706226|PMID:17141802) RGD PMID:17141802 MGI:3706226 NCBI chr 8:64,780,741...64,801,355
Ensembl chr 8:64,780,828...64,801,352 		JBrowse link
G Tiprl TOR signaling pathway regulator involved_in ISO (PMID:17384681) RGD PMID:17384681 NCBI chr13:77,527,176...77,552,026
Ensembl chr13:77,527,176...77,552,074 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822 		JBrowse link
G Trex1 three prime repair exonuclease 1 acts_upstream_of_or_within ISO (MGI:3818783|PMID:18045533) RGD PMID:18045533 MGI:3818783 NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796 		JBrowse link
G Usp28 ubiquitin specific peptidase 28 involved_in ISS
IBA
ISO
IEA		 GO_REF:0000024
PMID:21873635
(PMID:18662541)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:18662541 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr 8:49,325,766...49,386,229
Ensembl chr 8:49,325,867...49,386,229 		JBrowse link
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp2 caspase 2 involved_in ISO (PMID:21726810) RGD PMID:21726810 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A involved_in ISO (PMID:15149599) RGD PMID:15149599 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain involved_in IBA
ISO		 PMID:21873635
(PMID:21726810)		 RGD PMID:21726810 PMID:21873635 RGD:13792537 NCBI chr 7:29,940,240...29,952,907
Ensembl chr 7:29,798,586...29,952,907 		JBrowse link
G Mdm2 MDM2 proto-oncogene involved_in ISO (PMID:21726810) RGD PMID:21726810 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Muc1 mucin 1, cell surface associated involved_in ISO (PMID:15710329) RGD PMID:15710329 NCBI chr 2:174,635,559...174,640,738
Ensembl chr 2:174,635,995...174,640,733 		JBrowse link
G Pidd1 p53-induced death domain protein 1 involved_in ISO (PMID:21726810) RGD PMID:21726810 NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699 		JBrowse link
G Pml PML nuclear body scaffold involved_in ISO (MGI:3580934|PMID:15626733) RGD PMID:15626733 MGI:3580934 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma involved_in ISO (PMID:17245430) RGD PMID:17245430 NCBI chr 6:129,461,689...129,598,344
Ensembl chr 6:129,461,648...129,598,346 		JBrowse link
G Prap1 proline-rich acidic protein 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:23235459)		 UniProt
RGD		 PMID:23235459 GO_REF:0000024 NCBI chr 1:194,883,078...194,886,874
Ensembl chr 1:194,883,078...194,886,872 		JBrowse link
G Rbm38 RNA binding motif protein 38 involved_in ISO (PMID:17050675) RGD PMID:17050675 NCBI chr 3:161,801,550...161,814,381
Ensembl chr 3:161,801,577...161,814,381 		JBrowse link
G Rpl26 ribosomal protein L26 involved_in ISO
IEA		 (PMID:16213212)
GO_REF:0000107
(MGI:5882892|PMID:16213212)		 RGD
Ensembl		 PMID:16213212 GO_REF:0000107 MGI:5882892 NCBI chr10:53,610,836...53,613,966
Ensembl chr10:53,610,421...53,613,966 		JBrowse link
G Tp53 tumor protein p53 involved_in
acts_upstream_of_or_within		 ISO (PMID:16213212)
MGI:108027 (MGI:3589512|PMID:16107883)		 RGD PMID:16107883 PMID:16213212 MGI:3589512 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
DNA replication checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 involved_in IBA
ISO		 PMID:21873635
(MGI:2388867|PMID:12192004)
(PMID:14672932)		 RGD PMID:12192004 PMID:14672932 PMID:21873635 MGI:2388867, RGD:13792537 NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659 		JBrowse link
G Clspn claspin acts_upstream_of_or_within ISO (PMID:12766152) RGD PMID:12766152 NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034 		JBrowse link
G Dna2 DNA replication helicase/nuclease 2 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:22570476)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:22570476 GO_REF:0000024 GO_REF:0000107 NCBI chr20:25,661,652...25,690,598 JBrowse link
G Rad9a RAD9 checkpoint clamp component A involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:201,488,511...201,553,582
Ensembl chr 1:201,487,136...201,553,608 		JBrowse link
G Rad9b RAD9 checkpoint clamp component B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:34,217,868...34,248,380
Ensembl chr12:34,218,024...34,248,372 		JBrowse link
G Timeless timeless circadian regulator involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:654,804...678,769
Ensembl chr 7:654,822...678,738 		JBrowse link
G Tipin timeless interacting protein involved_in ISO
ISS
IEA
IBA		 (PMID:17102137)
GO_REF:0000024
GO_REF:0000104
PMID:21873635		 RGD
UniProt		 PMID:17102137 PMID:21873635 GO_REF:0000024 GO_REF:0000104, RGD:13792537 NCBI chr 8:64,780,741...64,801,355
Ensembl chr 8:64,780,828...64,801,352 		JBrowse link
G Tipinl1 TIMELESS interacting protein like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:113,542,841...113,544,022
Ensembl chr 9:113,543,173...113,605,998 		JBrowse link
meiotic cell cycle checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nsun2 NOP2/Sun RNA methyltransferase 2 involved_in ISO (MGI:5525987|PMID:23401851) RGD PMID:23401851 MGI:5525987 NCBI chr 1:33,662,139...33,685,887
Ensembl chr 1:33,662,139...33,685,862 		JBrowse link
meiotic DNA integrity checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hus1 HUS1 checkpoint clamp component involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:83,688,702...83,703,466
Ensembl chr14:83,688,708...83,703,442 		JBrowse link
G LOC103690165 checkpoint protein HUS1B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
meiotic recombination checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hormad1 HORMA domain containing 1 involved_in
acts_upstream_of_or_within		 IBA
ISO
ISS		 PMID:21873635
(MGI:4868505|PMID:21079677), (MGI:5009722|PMID:21478856)
MGI:5587823 (MGI:5586966|PMID:22530760)
GO_REF:0000024		 RGD
UniProt		 PMID:21079677 PMID:21478856 PMID:22530760 PMID:21873635 GO_REF:0000024 MGI:4868505 MGI:5009722 MGI:5586966, RGD:13792537 NCBI chr 2:183,115,815...183,152,383
Ensembl chr 2:183,116,716...183,152,383 		JBrowse link
G Rad1 RAD1 checkpoint DNA exonuclease involved_in ISO UniProtKB:P22193 (PMID:9716408) RGD PMID:9716408 NCBI chr 2:59,461,597...59,469,707
Ensembl chr 2:59,461,607...59,469,689 		JBrowse link
G Trip13 thyroid hormone receptor interactor 13 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074 		JBrowse link
meiotic spindle assembly checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttk Ttk protein kinase involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:5056148 (MGI:5049806|PMID:21558374)		 RGD PMID:21558374 PMID:21873635 MGI:5049806, RGD:13792537 NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651 		JBrowse link
meiotic spindle checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chfr checkpoint with forkhead and ring finger domains involved_in ISO (PMID:10935642) RGD PMID:10935642 NCBI chr12:46,504,497...46,538,104
Ensembl chr12:46,504,497...46,538,014 		JBrowse link
mitotic cytokinesis checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurkb aurora kinase B involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G Chmp4c charged multivesicular body protein 4C involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:22422861), (PMID:24814515)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:22422861 PMID:24814515 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:91,391,729...91,428,652
Ensembl chr 2:91,388,530...91,428,668 		JBrowse link
G Vps4a vacuolar protein sorting 4 homolog A involved_in ISS
ISO		 GO_REF:0000024
(PMID:24814515)		 UniProt
RGD		 PMID:24814515 GO_REF:0000024 NCBI chr19:34,934,999...34,948,267
Ensembl chr19:34,934,961...34,948,887 		JBrowse link
G Zfyve19 zinc finger FYVE-type containing 19 involved_in ISO
IBA		 (PMID:24814515)
PMID:21873635		 RGD PMID:24814515 PMID:21873635 RGD:13792537 NCBI chr 3:106,195,779...106,203,969
Ensembl chr 3:106,195,899...106,203,969 		JBrowse link
mitotic DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chek2 checkpoint kinase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Stk33 serine/threonine kinase 33 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:163,276,176...163,458,580
Ensembl chr 1:163,276,340...163,458,627 		JBrowse link
G Zfp830 zinc finger protein 830 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:3583779 (MGI:5428139|PMID:23213458)		 RGD PMID:23213458 PMID:21873635 MGI:5428139, RGD:13792537 NCBI chr10:67,701,340...67,702,804
Ensembl chr10:67,701,073...67,704,523 		JBrowse link
mitotic DNA integrity checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Setmar SET domain and mariner transposase fusion gene involved_in ISO (PMID:18790802) RGD PMID:18790802 NCBI chr 4:141,046,058...141,058,183
Ensembl chr 4:141,046,069...141,058,197 		JBrowse link
mitotic DNA replication checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07049960.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Cdc6 cell division cycle 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011 		JBrowse link
G Clspn claspin involved_in ISO
IBA		 (PMID:16885022)
PMID:21873635		 RGD PMID:16885022 PMID:21873635 RGD:13792537 NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034 		JBrowse link
G Hus1 HUS1 checkpoint clamp component involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:83,688,702...83,703,466
Ensembl chr14:83,688,708...83,703,442 		JBrowse link
G LOC103690165 checkpoint protein HUS1B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Nae1 NEDD8 activating enzyme E1 subunit 1 involved_in ISO
IEA		 (PMID:10722740)
GO_REF:0000107		 RGD
Ensembl		 PMID:10722740 GO_REF:0000107 NCBI chr19:446,015...472,145
Ensembl chr19:446,000...472,371 		JBrowse link
G Orc1 origin recognition complex, subunit 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375 		JBrowse link
G Rad17 RAD17 checkpoint clamp loader component involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:31,764,260...31,794,542
Ensembl chr 2:31,764,261...31,794,072 		JBrowse link
G Ticrr TOPBP1-interacting checkpoint and replication regulator involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:133,597,618...133,639,513
Ensembl chr 1:133,597,716...133,639,523 		JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674 		JBrowse link
G Zfp830 zinc finger protein 830 involved_in ISS
ISO
IBA		 GO_REF:0000024
(MGI:4950701|PMID:21191184)
PMID:21873635		 UniProt
RGD		 PMID:21191184 PMID:21873635 GO_REF:0000024 MGI:4950701, RGD:13792537 NCBI chr10:67,701,340...67,702,804
Ensembl chr10:67,701,073...67,704,523 		JBrowse link
mitotic G1 DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd1 cyclin D1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:19412162)		 UniProt
RGD		 PMID:19412162 GO_REF:0000024 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Dgkz diacylglycerol kinase zeta involved_in ISO UniProtKB:P06400 (PMID:16286473) RGD PMID:16286473 NCBI chr 3:77,904,149...77,946,114
Ensembl chr 3:77,904,150...77,946,099 		JBrowse link
G Fbxo31 F-box protein 31 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:19412162)
GO_REF:0000002		 UniProt
RGD
InterPro		 PMID:19412162 GO_REF:0000002 GO_REF:0000024 NCBI chr19:49,624,818...49,656,083
Ensembl chr19:49,627,686...49,656,010 		JBrowse link
G Gigyf2 GRB10 interacting GYF protein 2 acts_upstream_of_or_within ISO MGI:4126459 (MGI:4366664|PMID:19744960) RGD PMID:19744960 MGI:4366664 NCBI chr 9:88,001,212...88,127,040
Ensembl chr 9:88,001,301...88,125,715 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit involved_in ISO (PMID:21731742) RGD PMID:21731742 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Rfwd3 ring finger and WD repeat domain 3 involved_in ISO (PMID:20173098) RGD PMID:20173098 NCBI chr19:39,235,883...39,268,536
Ensembl chr19:39,236,787...39,268,479 		JBrowse link
G Rpa2 replication protein A2 involved_in ISO (PMID:21731742) RGD PMID:21731742 NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350 		JBrowse link
G Rps27l ribosomal protein S27-like involved_in ISO (PMID:18056458) RGD PMID:18056458 NCBI chr 8:67,562,483...67,567,418
Ensembl chr 8:67,562,483...67,567,418 		JBrowse link
G Sde2 SDE2 telomere maintenance homolog involved_in IEA
ISO		 GO_REF:0000107
(PMID:27906959)		 Ensembl
RGD		 PMID:27906959 GO_REF:0000107 NCBI chr13:92,578,843...92,595,142
Ensembl chr13:92,578,874...92,595,140 		JBrowse link
G Tp53 tumor protein p53 involved_in
acts_upstream_of_or_within		 ISO (PMID:7958916)
(MGI:3589512|PMID:16107883)		 RGD PMID:7958916 PMID:16107883 MGI:3589512 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trex1 three prime repair exonuclease 1 acts_upstream_of_or_within ISO MGI:3052754 (MGI:3818783|PMID:18045533), (MGI:5562498|PMID:23993650) RGD PMID:18045533 PMID:23993650 MGI:3818783 MGI:5562498 NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796 		JBrowse link
G Wac WW domain containing adaptor with coiled-coil involved_in ISO (PMID:21329877) RGD PMID:21329877 NCBI chr17:55,922,686...55,984,286
Ensembl chr17:55,923,123...55,982,301 		JBrowse link
mitotic G1/S transition checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plk3 polo-like kinase 3 involved_in IBA
ISO
ISS		 PMID:21873635
(MGI:5142362|PMID:21376736)
GO_REF:0000024		 RGD
UniProt		 PMID:21376736 PMID:21873635 GO_REF:0000024 MGI:5142362, RGD:13792537 NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317 		JBrowse link
G Plk5 polo-like kinase 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:9,346,777...9,367,923
Ensembl chr 7:9,346,777...9,355,196 		JBrowse link
mitotic G2 DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07049960.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Abraxas1 abraxas 1, BRCA1 A complex subunit involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:17525340), (PMID:17643121), (PMID:19261748)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:17525340 PMID:17643121 PMID:19261748 GO_REF:0000024 GO_REF:0000107 NCBI chr14:8,796,281...8,810,625
Ensembl chr14:8,796,266...8,810,622 		JBrowse link
G Atm ATM serine/threonine kinase involved_in ISO (PMID:15149599) RGD PMID:15149599 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Babam1 BRISC and BRCA1 A complex member 1 involved_in ISS
IBA
ISO		 GO_REF:0000024
PMID:21873635
(PMID:19261746), (PMID:19261748), (PMID:19261749)		 UniProt
RGD		 PMID:19261746 PMID:19261748 PMID:19261749 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr16:18,068,830...18,074,938
Ensembl chr16:18,068,884...18,074,923 		JBrowse link
G Babam2 BRISC and BRCA1 A complex member 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:19261748)		 UniProt
RGD		 PMID:19261748 GO_REF:0000024 NCBI chr 6:24,369,021...24,833,335
Ensembl chr 6:24,369,022...24,833,951 		JBrowse link
G Blm BLM RecQ like helicase involved_in ISO (PMID:11309417) RGD PMID:11309417 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312 		JBrowse link
G Brca1 BRCA1, DNA repair associated involved_in ISO
IEA		 (PMID:17525340), (PMID:17643121), (PMID:19261748)
GO_REF:0000107		 RGD
Ensembl		 PMID:17525340 PMID:17643121 PMID:19261748 GO_REF:0000107 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Brcc3 BRCA1/BRCA2-containing complex, subunit 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:17525341), (PMID:19261746), (PMID:19261748)		 UniProt
RGD		 PMID:17525341 PMID:19261746 PMID:19261748 GO_REF:0000024 NCBI chr 9:1,986,942...1,989,484
Ensembl chr 9:1,986,575...1,991,080 		JBrowse link
G Brsk1 BR serine/threonine kinase 1 involved_in ISO (PMID:15150265) RGD PMID:15150265 NCBI chr 1:69,134,166...69,159,947
Ensembl chr 1:69,134,565...69,160,365 		JBrowse link
G Brsk2 BR serine/threonine kinase 2 involved_in ISS PMID:15150265 UniProt PMID:15150265 RGD:8554801 NCBI chr 1:197,035,522...197,088,624
Ensembl chr 1:197,035,633...197,088,092 		JBrowse link
G Ccng1 cyclin G1 IMP RGD PMID:9464250 RGD:2316029 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641 		JBrowse link
G Cdc14b cell division cycle 14B involved_in ISO (PMID:18662541) RGD PMID:18662541 NCBI chr17:844,731...934,787
Ensembl chr17:844,685...933,235 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:2679752|PMID:12937170)		 RGD PMID:12937170 PMID:21873635 MGI:2679752, RGD:13792537 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 involved_in ISO
IEA
ISS		 (PMID:15790566)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:15790566 GO_REF:0000024 GO_REF:0000107 NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A involved_in ISO (PMID:23213251) RGD PMID:23213251 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chek1 checkpoint kinase 1 involved_in ISO (PMID:20932473) RGD PMID:20932473 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Clspn claspin involved_in ISO
IBA		 (PMID:18662541)
PMID:21873635		 RGD PMID:18662541 PMID:21873635 RGD:13792537 NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034 		JBrowse link
G Donson DNA replication fork stabilization factor DONSON involved_in ISO (PMID:28191891) RGD PMID:28191891 NCBI chr11:30,911,616...30,933,150
Ensembl chr11:30,923,239...30,932,889 		JBrowse link
G Dtl denticleless E3 ubiquitin protein ligase homolog involved_in ISO (PMID:17085480) RGD PMID:17085480 NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890 		JBrowse link
G Foxn3 forkhead box N3 involved_in ISO UniProtKB:P38111 (PMID:9154802) RGD PMID:9154802 NCBI chr 6:118,462,018...118,842,442
Ensembl chr 6:118,466,025...118,842,401 		JBrowse link
G Foxo4 forkhead box O4 acts_upstream_of_or_within ISO (MGI:2183145|PMID:12048180) RGD PMID:12048180 MGI:2183145 NCBI chr  X:66,385,241...66,392,115
Ensembl chr  X:66,385,558...66,392,115 		JBrowse link
G Fzr1 fizzy and cell division cycle 20 related 1 involved_in ISO (PMID:18662541) RGD PMID:18662541 NCBI chr 7:8,332,029...8,343,953
Ensembl chr 7:8,332,029...8,343,952 		JBrowse link
G Hmga2 high mobility group AT-hook 2 involved_in ISO
ISS		 (PMID:16061642)
GO_REF:0000024		 RGD
UniProt		 PMID:16061642 GO_REF:0000024 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784 		JBrowse link
G Ier3 immediate early response 3 acts_upstream_of_or_within ISO MGI:3773690 (MGI:5432078|PMID:20467439) RGD PMID:20467439 MGI:5432078 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G LOC100302465 hypothetical LOC100302465 involved_in ISO (MGI:4455105|PMID:20154723) RGD PMID:20154723 MGI:4455105 NCBI chr 1:189,059,744...189,293,353
Ensembl chr 1:189,059,746...189,293,435 		JBrowse link
G Mbd4 methyl-CpG binding domain 4 DNA glycosylase acts_upstream_of_or_within ISO MGI:2684310 (MGI:2682526|PMID:14614141) RGD PMID:14614141 MGI:2682526 NCBI chr 4:148,893,049...148,904,833
Ensembl chr 4:148,894,280...148,904,982 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:3027036 (MGI:2683367|PMID:14690604)
PMID:21873635		 Ensembl
RGD		 PMID:14690604 PMID:21873635 GO_REF:0000107 MGI:2683367, RGD:13792537 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279 		JBrowse link
G Mrnip MRN complex interacting protein involved_in ISO (PMID:27568553) RGD PMID:27568553 NCBI chr10:34,501,359...34,525,474
Ensembl chr10:34,501,384...34,525,469 		JBrowse link
G Nbn nibrin involved_in
acts_upstream_of_or_within		 IBA
ISO
IEA
ISS		 PMID:21873635
MGI:2183796 (MGI:3805397|PMID:18614044)
GO_REF:0000107
GO_REF:0000024
(PMID:11438675)		 RGD
Ensembl
UniProt		 PMID:11438675 PMID:18614044 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:3805397, RGD:13792537 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150 		JBrowse link
G Nop53 NOP53 ribosome biogenesis factor involved_in ISO (PMID:21741933) RGD PMID:21741933 NCBI chr 1:76,629,084...76,636,902
Ensembl chr 1:76,629,069...76,636,902 		JBrowse link
G Plk1 polo-like kinase 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:18662541)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:18662541 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400 		JBrowse link
G Rint1 RAD50 interactor 1 involved_in ISO (PMID:11096100) RGD PMID:11096100 NCBI chr 4:11,319,416...11,355,773
Ensembl chr 4:11,320,955...11,355,736 		JBrowse link
G Syf2 SYF2 pre-mRNA-splicing factor acts_upstream_of_or_within ISO MGI:3904866 (MGI:5435138|PMID:22448250) RGD PMID:22448250 MGI:5435138 NCBI chr 5:147,156,492...147,164,416
Ensembl chr 5:147,156,480...147,164,414 		JBrowse link
G Taok1 TAO kinase 1 involved_in ISO
IEA
ISS		 (PMID:17396146)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:17396146 GO_REF:0000024 GO_REF:0000107 NCBI chr10:62,373,076...62,465,295
Ensembl chr10:62,381,404...62,465,766 		JBrowse link
G Taok2 TAO kinase 2 involved_in ISO
IEA
ISS		 (PMID:17396146)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:17396146 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:181,475,708...181,494,738
Ensembl chr 1:181,475,711...181,494,613 		JBrowse link
G Taok3 TAO kinase 3 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:17396146)		 Ensembl
UniProt
RGD		 PMID:17396146 GO_REF:0000024 GO_REF:0000107 NCBI chr12:39,314,027...39,394,243
Ensembl chr12:39,314,027...39,461,244 		JBrowse link
G Ticrr TOPBP1-interacting checkpoint and replication regulator involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:133,597,618...133,639,513
Ensembl chr 1:133,597,716...133,639,523 		JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674 		JBrowse link
G Trim39 tripartite motif-containing 39 involved_in ISO
IEA
ISS		 (PMID:23213251)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:23213251 GO_REF:0000024 GO_REF:0000107 NCBI chr20:2,003,320...2,017,175
Ensembl chr20:1,983,533...2,020,117 		JBrowse link
G Uimc1 ubiquitin interaction motif containing 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:17525340), (PMID:17525341), (PMID:17525342), (PMID:17643121), (PMID:19261748)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:17525340 PMID:17525341 PMID:17525342 PMID:17643121 PMID:19261748 GO_REF:0000024 GO_REF:0000107 NCBI chr17:9,523,793...9,592,810
Ensembl chr17:9,527,794...9,592,799 		JBrowse link
mitotic G2/M transition checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca1 BRCA1, DNA repair associated acts_upstream_of_or_within ISO (MGI:3052267|PMID:15254237) RGD PMID:15254237 MGI:3052267 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 involved_in ISO
ISS		 (PMID:19223857)
GO_REF:0000024		 RGD
UniProt		 PMID:19223857 GO_REF:0000024 NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590 		JBrowse link
G Chek1 checkpoint kinase 1 involved_in ISO
ISS		 (PMID:33108758)
GO_REF:0000024		 RGD
UniProt		 PMID:33108758 GO_REF:0000024 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Chfr checkpoint with forkhead and ring finger domains involved_in ISS
ISO		 GO_REF:0000024
(PMID:18172500), (PMID:19182791)		 UniProt
RGD		 PMID:18172500 PMID:19182791 GO_REF:0000024 NCBI chr12:46,504,497...46,538,104
Ensembl chr12:46,504,497...46,538,014 		JBrowse link
G Inip INTS3 and NABP interacting protein involved_in ISO (PMID:19683501) RGD PMID:19683501 NCBI chr 5:74,648,392...74,662,628
Ensembl chr 5:74,648,392...74,662,628 		JBrowse link
G Ints3 integrator complex subunit 3 involved_in ISO (PMID:19683501) RGD PMID:19683501 NCBI chr 2:175,859,421...175,911,683
Ensembl chr 2:175,859,440...175,911,709 		JBrowse link
G Nabp1 nucleic acid binding protein 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:19683501)		 UniProt
RGD		 PMID:19683501 GO_REF:0000024 NCBI chr 9:50,098,552...50,133,982
Ensembl chr 9:50,126,726...50,134,107 		JBrowse link
G Nabp2 nucleic acid binding protein 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:19683501)		 UniProt
RGD		 PMID:19683501 GO_REF:0000024 NCBI chr 7:830,949...836,551
Ensembl chr 7:830,949...838,027 		JBrowse link
G Pabir1 PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 involved_in ISO
IBA
ISS		 (PMID:33108758)
PMID:21873635
GO_REF:0000024		 RGD
UniProt		 PMID:33108758 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:222,114,988...222,116,294
Ensembl chr 1:222,112,591...222,116,396 		JBrowse link
mitotic intra-S DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 involved_in ISO
ISS		 (PMID:15916964)
GO_REF:0000024		 RGD
UniProt		 PMID:15916964 GO_REF:0000024 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Chek2 checkpoint kinase 2 involved_in ISO (PMID:11298456) RGD PMID:11298456 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Eme1 essential meiotic structure-specific endonuclease 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:79,586,736...79,595,515
Ensembl chr10:79,586,729...79,595,435 		JBrowse link
G Eme2 essential meiotic structure-specific endonuclease subunit 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:13,913,216...13,915,991
Ensembl chr10:13,913,221...13,915,968 		JBrowse link
G Fancd2 FA complementation group D2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412 		JBrowse link
G Hus1 HUS1 checkpoint clamp component involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:83,688,702...83,703,466
Ensembl chr14:83,688,708...83,703,442 		JBrowse link
G LOC103690165 checkpoint protein HUS1B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Mre11 MRE11 homolog, double strand break repair nuclease involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:3027036 (MGI:2683367|PMID:14690604), (MGI:3805397|PMID:18614044)
PMID:21873635		 Ensembl
RGD		 PMID:14690604 PMID:18614044 PMID:21873635 GO_REF:0000107 MGI:2683367 MGI:3805397, RGD:13792537 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279 		JBrowse link
G Msh2 mutS homolog 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:103557 (MGI:3512823|PMID:15533840)		 Ensembl
RGD		 PMID:15533840 GO_REF:0000107 MGI:3512823 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Mus81 MUS81 structure-specific endonuclease subunit involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:202,790,295...202,796,008
Ensembl chr 1:202,790,466...202,795,843 		JBrowse link
G Nek11 NIMA-related kinase 11 involved_in ISO
IBA		 (PMID:15161910)
PMID:21873635		 RGD PMID:15161910 PMID:21873635 RGD:13792537 NCBI chr 8:105,767,230...106,026,676
Ensembl chr 8:105,770,548...106,026,676 		JBrowse link
G Rad17 RAD17 checkpoint clamp loader component involved_in ISO (PMID:15538388) RGD PMID:15538388 NCBI chr 2:31,764,260...31,794,542
Ensembl chr 2:31,764,261...31,794,072 		JBrowse link
G Rad9a RAD9 checkpoint clamp component A involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
UniProtKB:P26306 (MGI:1289930|PMID:9766521)		 RGD PMID:9766521 PMID:21873635 MGI:1289930, RGD:13792537 NCBI chr 1:201,488,511...201,553,582
Ensembl chr 1:201,487,136...201,553,608 		JBrowse link
G Rad9b RAD9 checkpoint clamp component B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:34,217,868...34,248,380
Ensembl chr12:34,218,024...34,248,372 		JBrowse link
G Tipin timeless interacting protein involved_in ISS
ISO		 GO_REF:0000024
(PMID:17102137)		 UniProt
RGD		 PMID:17102137 GO_REF:0000024 NCBI chr 8:64,780,741...64,801,355
Ensembl chr 8:64,780,828...64,801,352 		JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor acts_upstream_of_or_within ISO MGI:101816 (MGI:3512823|PMID:15533840) RGD PMID:15533840 MGI:3512823 NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010 		JBrowse link
mitotic spindle assembly checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:17227893)
GO_REF:0000107		 RGD
Ensembl		 PMID:17227893 GO_REF:0000107 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Atm ATM serine/threonine kinase involved_in ISO (PMID:11943150) RGD PMID:11943150 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Aurkb aurora kinase B involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 involved_in ISO
ISS		 (PMID:12805209)
GO_REF:0000024		 RGD
UniProt		 PMID:12805209 GO_REF:0000024 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650 		JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B involved_in IBA
ISO		 PMID:21873635
(PMID:10477750)		 RGD PMID:10477750 PMID:21873635 RGD:13792537 NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547 		JBrowse link
G Bub3 BUB3 mitotic checkpoint protein involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:186,330,358...186,340,969
Ensembl chr 1:186,327,931...186,395,036 		JBrowse link
G Cenpe centromere protein E involved_in ISO (MGI:2673075|PMID:12925705) RGD PMID:12925705 MGI:2673075 NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669 		JBrowse link
G Ik IK cytokine involved_in ISS
ISO		 GO_REF:0000024
(PMID:22351768)		 UniProt
RGD		 PMID:22351768 GO_REF:0000024 NCBI chr18:28,358,004...28,372,809
Ensembl chr18:28,357,977...28,378,832 		JBrowse link
G Khdc3 KH domain containing 3, subcortical maternal complex member acts_upstream_of_or_within ISO MGI:3844604 (MGI:3844372|PMID:19376971) RGD PMID:19376971 MGI:3844372 NCBI chr 8:73,842,344...73,844,248
Ensembl chr 8:73,842,344...73,844,248 		JBrowse link
G Klhl22 kelch-like family member 22 involved_in IBA
IEA
ISO
ISS		 PMID:21873635
GO_REF:0000107
(PMID:23455478)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:23455478 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr11:83,190,891...83,231,746
Ensembl chr11:83,190,891...83,231,770 		JBrowse link
G Kntc1 kinetochore associated 1 involved_in ISO (PMID:11146660) RGD PMID:11146660 NCBI chr12:32,769,020...32,839,617
Ensembl chr12:32,769,020...32,839,561 		JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in IBA
ISO		 PMID:21873635
(PMID:18981471), (PMID:9546394)		 RGD PMID:9546394 PMID:18981471 PMID:21873635 RGD:13792537 NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703 		JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:18981471)
MGI:2178781 (MGI:1930685|PMID:11201745)
PMID:21873635		 RGD PMID:11201745 PMID:18981471 PMID:21873635 MGI:1930685, RGD:13792537 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470 		JBrowse link
G Plk1 polo-like kinase 1 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:23455478)		 Ensembl
UniProt
RGD		 PMID:23455478 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400 		JBrowse link
G Psmg2 proteasome assembly chaperone 2 acts_upstream_of_or_within ISO (MGI:2388532|PMID:12147697) RGD PMID:12147697 MGI:2388532 NCBI chr18:61,208,669...61,227,671
Ensembl chr18:61,208,678...61,259,816 		JBrowse link
G Spdl1 spindle apparatus coiled-coil protein 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:19,269,125...19,294,213
Ensembl chr10:19,269,127...19,294,127 		JBrowse link
G Tex14 testis expressed 14, intercellular bridge forming factor involved_in IEA
ISO
IBA
ISS		 GO_REF:0000107
(MGI:5318128|PMID:22405274)
PMID:21873635
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:22405274 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:5318128, RGD:13792537 NCBI chr10:72,231,766...72,356,938
Ensembl chr10:72,231,801...72,355,805 		JBrowse link
G Tpr translocated promoter region, nuclear basket protein involved_in ISO
ISS		 (PMID:20133940)
GO_REF:0000024		 RGD
UniProt		 PMID:20133940 GO_REF:0000024 NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496 		JBrowse link
G Trip13 thyroid hormone receptor interactor 13 involved_in ISO
ISS		 (PMID:28553959)
GO_REF:0000024		 RGD
UniProt		 PMID:28553959 GO_REF:0000024 NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074 		JBrowse link
G Ttk Ttk protein kinase involved_in IBA
ISO		 PMID:21873635
MGI:5056148 (MGI:5608719|PMID:25197064)		 RGD PMID:25197064 PMID:21873635 MGI:5608719, RGD:13792537 NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651 		JBrowse link
G Zfp207 zinc finger protein 207 involved_in IBA
ISO		 PMID:21873635
(PMID:24462186), (PMID:24462187)		 RGD PMID:24462186 PMID:24462187 PMID:21873635 RGD:13792537 NCBI chr10:65,385,823...65,397,591
Ensembl chr10:65,385,740...65,397,386 		JBrowse link
G Zw10 zw10 kinetochore protein involved_in ISS
ISO
IBA		 GO_REF:0000024
(PMID:11146660), (PMID:15824131)
PMID:21873635		 HGNC-UCL
RGD		 PMID:11146660 PMID:15824131 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 8:49,396,541...49,424,743
Ensembl chr 8:49,396,545...49,421,805 		JBrowse link
G Zwilch zwilch kinetochore protein involved_in IBA
ISO		 PMID:21873635
(PMID:15824131)		 RGD PMID:15824131 PMID:21873635 RGD:13792537 NCBI chr 8:64,638,401...64,670,911
Ensembl chr 8:64,637,672...64,675,916 		JBrowse link
G Zwint ZW10 interacting kinetochore protein involved_in ISO (PMID:15485811) RGD PMID:15485811 NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957 		JBrowse link
negative regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd4 bromodomain containing 4 involved_in ISO (PMID:23728299) RGD PMID:23728299 NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539 		JBrowse link
G Chek2 checkpoint kinase 2 IMP RGD PMID:20637979 RGD:10401658 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Da2-19 uncharacterized LOC302729 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr  X:44,820,693...44,837,935
Ensembl chr  X:44,820,820...44,837,934 		JBrowse link
G Ddx39b DExD-box helicase 39B involved_in ISS
ISO		 GO_REF:0000024
(PMID:22144908)		 UniProt
RGD		 PMID:22144908 GO_REF:0000024 NCBI chr20:3,547,702...3,585,064
Ensembl chr20:3,572,056...3,584,996 		JBrowse link
G Thoc1 THO complex 1 involved_in ISO (PMID:22144908) RGD PMID:22144908 NCBI chr18:983,606...1,020,379
Ensembl chr18:983,824...1,019,114 		JBrowse link
G Thoc5 THO complex 5 involved_in ISS
ISO		 GO_REF:0000024
(PMID:22144908)		 UniProt
RGD		 PMID:22144908 GO_REF:0000024 NCBI chr14:79,758,805...79,792,718
Ensembl chr14:79,758,917...79,792,718 		JBrowse link
negative regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:Q15554 (PMID:23426265)		 Ensembl
RGD		 PMID:23426265 GO_REF:0000107 NCBI chr20:2,822,995...2,838,125
Ensembl chr20:2,822,995...2,837,611 		JBrowse link
positive regulation of cell cycle checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prox1 prospero homeobox 1 acts_upstream_of_or_within ISO (MGI:4946187|PMID:21040746) RGD PMID:21040746 MGI:4946187 NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183 		JBrowse link
positive regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccar2 cell cycle and apoptosis regulator 2 involved_in ISO (PMID:23352644) RGD PMID:23352644 NCBI chr15:45,212,797...45,228,001
Ensembl chr15:45,212,803...45,227,636 		JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:19229290)		 UniProt
Ensembl
RGD		 PMID:19229290 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:114,376,649...114,410,297
Ensembl chr 8:114,376,662...114,410,934 		JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease involved_in ISO (PMID:23108668) RGD PMID:23108668 NCBI chr 6:33,947,599...33,978,461
Ensembl chr 6:33,948,206...33,978,401 		JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in ISO (PMID:22898774) RGD PMID:22898774 NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703 		JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 involved_in ISO (MGI:4839685|PMID:20870947)
(PMID:20870947), (PMID:22898774), (PMID:8824189)		 RGD PMID:8824189 PMID:20870947 PMID:22898774 MGI:4839685 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470 		JBrowse link
G Ndc80 NDC80 kinetochore complex component involved_in ISO (PMID:25743205) RGD PMID:25743205 NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924 		JBrowse link
G Pcid2 PCI domain containing 2 involved_in ISO (PMID:20870947)
(MGI:4839685|PMID:20870947)		 RGD PMID:20870947 MGI:4839685 NCBI chr16:76,423,245...76,448,712
Ensembl chr16:76,423,245...76,448,712 		JBrowse link
G Tpr translocated promoter region, nuclear basket protein involved_in ISS
ISO		 GO_REF:0000024
(PMID:18981471), (PMID:19273613)		 UniProt
RGD		 PMID:18981471 PMID:19273613 GO_REF:0000024 NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496 		JBrowse link
G Xrcc3 X-ray repair cross complementing 3 involved_in ISO (PMID:23108668) RGD PMID:23108668 NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444 		JBrowse link
positive regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map3k20 mitogen-activated protein kinase kinase kinase 20 involved_in ISO (PMID:15342622) RGD PMID:15342622 NCBI chr 3:57,128,561...57,289,943
Ensembl chr 3:57,130,551...57,289,626 		JBrowse link
regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cry1 cryptochrome circadian regulator 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5567851|PMID:24489120)		 UniProt
RGD		 PMID:24489120 GO_REF:0000024 MGI:5567851 NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091 		JBrowse link
G Cul4a cullin 4A acts_upstream_of_or_within ISO MGI:3851025 (MGI:3850765|PMID:19481525) RGD PMID:19481525 MGI:3850765 NCBI chr16:76,385,298...76,422,316
Ensembl chr16:76,384,546...76,422,330 		JBrowse link
G Etaa1 ETAA1 activator of ATR kinase involved_in ISO
IBA		 (PMID:27723717), (PMID:27723720)
PMID:21873635		 RGD PMID:27723717 PMID:27723720 PMID:21873635 RGD:13792537 Ensembl chr14:92,299,553...92,314,104 JBrowse link
G Fbxo4 F-box protein 4 acts_upstream_of_or_within ISO MGI:5301830 (MGI:5299398|PMID:21911473) RGD PMID:21911473 MGI:5299398 NCBI chr 2:53,174,798...53,187,792
Ensembl chr 2:53,174,798...53,187,792 		JBrowse link
G Fem1b fem-1 homolog B involved_in ISS
ISO		 GO_REF:0000024
(PMID:19330022)		 UniProt
RGD		 PMID:19330022 GO_REF:0000024 NCBI chr 8:63,265,301...63,278,577
Ensembl chr 8:63,265,301...63,278,577 		JBrowse link
G Nek1 NIMA-related kinase 1 involved_in ISO (MGI:5619475|PMID:18843199) RGD PMID:18843199 MGI:5619475 NCBI chr16:28,998,229...29,125,426
Ensembl chr16:28,998,231...29,117,723 		JBrowse link
G Rfwd3 ring finger and WD repeat domain 3 involved_in ISO (PMID:21504906) RGD PMID:21504906 NCBI chr19:39,235,883...39,268,536
Ensembl chr19:39,236,787...39,268,479 		JBrowse link
G Rnaseh2b ribonuclease H2, subunit B acts_upstream_of_or_within ISO MGI:4432164 (MGI:5435090|PMID:22802351) RGD PMID:22802351 MGI:5435090 NCBI chr15:36,541,200...36,592,016
Ensembl chr15:36,541,218...36,584,118 		JBrowse link
G Rpa2 replication protein A2 involved_in ISO
ISS		 (PMID:21504906)
GO_REF:0000024		 RGD
UniProt		 PMID:21504906 GO_REF:0000024 NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350 		JBrowse link
G Wdr76 WD repeat domain 76 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:108,456,784...108,491,528
Ensembl chr 3:108,456,815...108,490,840 		JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc15 anaphase promoting complex subunit 15 involved_in IBA
ISS
ISO		 PMID:21873635
GO_REF:0000024
(PMID:21926987)		 UniProt
RGD		 PMID:21926987 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:156,238,640...156,266,005
Ensembl chr 1:156,262,841...156,268,145 		JBrowse link
G Ccnb1 cyclin B1 involved_in ISO (PMID:18195732) RGD PMID:18195732 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:19282672)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:19282672 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:83,792,282...83,961,129
Ensembl chr 5:83,792,284...83,960,782 		JBrowse link
G Dusp1 dual specificity phosphatase 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:17724024)
GO_REF:0000107		 RGD
Ensembl		 PMID:17724024 GO_REF:0000107 NCBI chr 1:177,904,119...177,960,111
Ensembl chr 1:177,904,139...177,960,112 		JBrowse link
G Usp44 ubiquitin specific peptidase 44 involved_in ISO (MGI:5448515|PMID:21853124) RGD PMID:21853124 MGI:5448515 NCBI chr 7:28,364,169...28,412,039
Ensembl chr 7:28,364,033...28,410,053 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    cellular process 18359
      signal transduction 6908
        intracellular signal transduction 2630
          cell cycle checkpoint signaling 172
            DNA integrity checkpoint signaling + 123
            meiotic cell cycle checkpoint signaling + 8
            mitotic cell cycle checkpoint signaling + 132
            negative regulation of cell cycle checkpoint + 11
            positive regulation of cell cycle checkpoint + 11
            regulation of cell cycle checkpoint + 37
            spindle checkpoint signaling + 40
Path 2
Term Annotations click to browse term
  biological_process 19497
    biological regulation 13606
      regulation of biological process 12866
        regulation of cellular process 12336
          regulation of cell cycle 1067
            regulation of cell cycle process 697
              negative regulation of cell cycle process 286
                negative regulation of cell cycle phase transition 240
                  cell cycle checkpoint signaling 172
                    DNA integrity checkpoint signaling + 123
                    meiotic cell cycle checkpoint signaling + 8
                    mitotic cell cycle checkpoint signaling + 132
                    negative regulation of cell cycle checkpoint + 11
                    positive regulation of cell cycle checkpoint + 11
                    regulation of cell cycle checkpoint + 37
                    spindle checkpoint signaling + 40
paths to the root