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Gene: Gen1 (GEN1, Holliday junction 5' flap endonuclease) Mus musculus
Symbol: Gen1
Name: GEN1, Holliday junction 5' flap endonuclease
Description: Predicted to have several functions, including endodeoxyribonuclease activity; magnesium ion binding activity; and protein homodimerization activity. Predicted to be involved in DNA metabolic process and regulation of cell cycle process. Predicted to localize to the centrosome. Is expressed in embryo; nephric duct; and neural tube. Orthologous to human GEN1 (GEN1 Holliday junction 5' flap endonuclease); INTERACTS WITH 2-butoxyethanol; 4-hydroxynon-2-enal; carbon nanotube.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5830483C08Rik; flap endonuclease GEN homolog 1; Gen homolog 1, endonuclease; MGC115970
Homo sapiens (human) : GEN1 (GEN1 Holliday junction 5' flap endonuclease)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gen1 (GEN1 Holliday junction 5' flap endonuclease)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gen1 (GEN1 Holliday junction 5' flap endonuclease)
Pan paniscus (bonobo/pygmy chimpanzee) : GEN1 (GEN1 Holliday junction 5' flap endonuclease)
Canis lupus familiaris (dog) : GEN1 (GEN1 Holliday junction 5' flap endonuclease)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gen1 (GEN1 Holliday junction 5' flap endonuclease)
Sus scrofa (pig) : GEN1 (GEN1 Holliday junction 5' flap endonuclease)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381211,238,928 - 11,266,029 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371211,247,732 - 11,272,593 (-)NCBIGRCm37mm9NCBIm37
MGSCv361211,266,084 - 11,292,109 (-)NCBImm8
Celera1211,585,054 - 11,610,024 (-)NCBICelera
Cytogenetic Map12 A1.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Gen1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1558475
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.