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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of gene expression via chromosomal CpG island methylation
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Accession:GO:0044027 term browser browse the term
Definition:An epigenetic gene regulation mechanism that negatively regulates gene expression by methylation of cytosine residues in chromosomal CpG islands. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide associated with the transcription start site of genes.
Synonyms:exact_synonym: DNA hypermethylation of CpG island;   epigenetic regulation of gene expression via CpG island hypermethylation;   hypermethylation of CpG island;   negative regulation of gene expression via CpG island hypermethylation;   negative regulation of gene expression via chromosomal CpG dinucleotide methylation;   negative regulation of gene expression via chromosomal DNA cytosine methylation
 broad_synonym: maintenance of DNA methylation
 related_synonym: DNA hypermethylation of CG island;   negative regulation of gene expression via CpG island methylation;   negative regulation of gene expression via chromosomal CG dinucleotide methylation


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negative regulation of gene expression via chromosomal CpG island methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca1 BRCA1, DNA repair associated involved_in
acts_upstream_of_positive_effect		 IEA
ISO		 GO_REF:0000107
(PMID:20820192)		 Ensembl
RGD		 PMID:20820192 GO_REF:0000107 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Ctcf CCCTC-binding factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:14716017)		 Ensembl
RGD		 PMID:14716017 GO_REF:0000107 NCBI chr19:33,521,726...33,571,124
Ensembl chr19:33,529,319...33,571,123 		JBrowse link
G Dnmt1 DNA methyltransferase 1 involved_in IDA
IEA
ISO
IBA		 GO_REF:0000107
(PMID:18754681), (PMID:21745816), (PMID:24623306)
GO_REF:0000033
(PMID:17576694)		 Ensembl
RGD
GO_Central		 PMID:17576694 PMID:18754681 PMID:21745816 PMID:24623306 PMID:12473678 GO_REF:0000033 GO_REF:0000107, RGD:1359078 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha involved_in
acts_upstream_of_or_within		 ISS
ISO		 PMID:12138111
(PMID:12138111), (PMID:19786833), (PMID:23042785)
(PMID:30834655)
(PMID:21047779)		 RGD PMID:12138111 PMID:19786833 PMID:21047779 PMID:23042785 PMID:30834655 More... RGD:8554662 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687 		JBrowse link
G Dnmt3l DNA methyltransferase 3 like acts_upstream_of_or_within ISO (PMID:30834655) RGD PMID:30834655 NCBI chr20:10,614,933...10,629,337
Ensembl chr20:10,614,934...10,629,516 		JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 acts_upstream_of_or_within ISO (PMID:17212651) RGD PMID:17212651 NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547 		JBrowse link
G Hells helicase, lymphoid specific involved_in IBA
ISO		 GO_REF:0000033
(PMID:15105378)		 GO_Central
RGD		 PMID:15105378 GO_REF:0000033 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844 		JBrowse link
G Mecp2 methyl CpG binding protein 2 involved_in ISO (PMID:23960241) RGD PMID:23960241 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689 		JBrowse link
G Mphosph8 M-phase phosphoprotein 8 involved_in ISS
ISO		 GO_REF:0000024
(PMID:20871592)		 UniProt
RGD		 PMID:20871592 GO_REF:0000024 NCBI chr15:30,800,546...30,828,415
Ensembl chr15:30,686,613...30,828,810 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor acts_upstream_of_positive_effect ISO (PMID:19786833) RGD PMID:19786833 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Prmt5 protein arginine methyltransferase 5 IMP RGD PMID:22041901 RGD:9491827 NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296 		JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 involved_in IEA
ISS
ISO
IBA		 GO_REF:0000107
GO_REF:0000024
(PMID:17673620)
GO_REF:0000033
(PMID:17673620), (PMID:17994007)		 Ensembl
UniProt
RGD
GO_Central		 PMID:17673620 PMID:17994007 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631 		JBrowse link
G Uhrf2 ubiquitin like with PHD and ring finger domains 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:227,814,639...227,877,907
Ensembl chr 1:227,814,963...227,877,904 		JBrowse link
G Usp7 ubiquitin specific peptidase 7 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:21745816)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:21745816 GO_REF:0000024 GO_REF:0000107 NCBI chr10:6,880,684...6,925,355
Ensembl chr10:6,828,795...6,925,355 		JBrowse link
G Wt1 WT1 transcription factor involved_in
acts_upstream_of_positive_effect		 IEA
ISO		 GO_REF:0000107
(PMID:23042785)		 Ensembl
RGD		 PMID:23042785 GO_REF:0000107 NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643 		JBrowse link
G Zfp445 zinc finger protein 445 involved_in ISO (PMID:30602440)
UniProtKB:Q8C6P8 (PMID:30602440)		 RGD PMID:30602440 NCBI chr 8:122,453,175...122,473,355
Ensembl chr 8:122,454,328...122,473,286 		JBrowse link
G Zfp57 zinc finger protein 57 involved_in ISO UniProtKB:Q8R2V3 (PMID:30602440) RGD PMID:30602440 NCBI chr20:1,521,323...1,534,884
Ensembl chr20:1,521,323...1,529,846 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20076
    cellular process 19155
      metabolic process 11953
        biosynthetic process 8474
          macromolecule biosynthetic process 7498
            gene expression 7054
              negative regulation of gene expression 1384
                negative regulation of gene expression, epigenetic 199
                  negative regulation of gene expression via chromosomal CpG island methylation 17
Path 2
Term Annotations click to browse term
  biological_process 20076
    biological regulation 13559
      regulation of biological process 13136
        regulation of cellular process 12773
          regulation of metabolic process 6747
            regulation of biosynthetic process 5511
              regulation of macromolecule biosynthetic process 5309
                regulation of gene expression 5190
                  negative regulation of gene expression 1384
                    negative regulation of gene expression, epigenetic 199
                      negative regulation of gene expression via chromosomal CpG island methylation 17
paths to the root