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ONTOLOGY REPORT - ANNOTATIONS

Term:p38MAPK cascade
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Accession:GO:0038066 term browser browse the term
Definition:A MAPK cascade containing at least the p38MAPK (MAPK14) MAP kinase, or Hog1 in yeast. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of p38MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The p38MAPK cascade is activated by stress signals, including hyperosmolarity, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.
Synonyms:exact_synonym: p38 MAPK cascade;   p38 cascade
 narrow_synonym: osmosensory signaling MAPK cascade
 related_synonym: MAPK14 cascade

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p38MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936509:4,729,984...4,826,367
Ensembl chrNW_004936509:4,732,930...4,826,443 		JBrowse link
G Becn1 beclin 1 ISO RGD PMID:27769861 RGD:329853763 NCBI chrNW_004936490:17,518,100...17,531,126
Ensembl chrNW_004936490:17,517,751...17,531,151 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 acts_upstream_of_or_within ISO (PMID:20053668) MGI PMID:20053668 NCBI chrNW_004936477:21,591,772...21,606,289
Ensembl chrNW_004936477:21,591,792...21,606,296 		JBrowse link
G Kcnj8 potassium inwardly rectifying channel subfamily J member 8 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29540778) Ensembl
MGI		 PMID:29540778 GO_REF:0000107 NCBI chrNW_004936548:5,125,583...5,132,490
Ensembl chrNW_004936548:5,125,555...5,133,078 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:16116184) UniProt PMID:16116184 NCBI chrNW_004936538:4,034,467...4,050,240 JBrowse link
G LOC101960773 cyclic AMP-dependent transcription factor ATF-7 involved_in ISO (PMID:17699753) MGI PMID:17699753 NCBI chrNW_004936512:10,780,826...10,884,806
Ensembl chrNW_004936512:10,785,763...10,884,795 		JBrowse link
G Map1lc3a microtubule associated protein 1 light chain 3 alpha ISO RGD PMID:27769861 RGD:329853763 NCBI chrNW_004936561:6,104,748...6,106,348
Ensembl chrNW_004936561:6,104,742...6,106,699 		JBrowse link
G Map2k3 mitogen-activated protein kinase kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936741:362,682...386,633
Ensembl chrNW_004936741:362,387...386,678 		JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936509:3,029,942...3,203,319
Ensembl chrNW_004936509:3,029,979...3,202,796 		JBrowse link
G Map3k4 mitogen-activated protein kinase kinase kinase 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936489:11,908,083...11,972,186
Ensembl chrNW_004936489:11,909,922...11,975,715 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936560:3,988,696...4,197,953
Ensembl chrNW_004936560:3,989,420...4,197,501 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936510:1,772,971...1,836,075
Ensembl chrNW_004936510:1,772,971...1,837,765 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936629:542,143...549,861
Ensembl chrNW_004936629:545,755...549,837 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936476:23,237,762...23,310,211
Ensembl chrNW_004936476:23,237,277...23,310,232 		JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24020373) Ensembl
MGI		 PMID:24020373 GO_REF:0000107 NCBI chrNW_004936557:5,867,182...5,911,207
Ensembl chrNW_004936557:5,867,211...5,911,213 		JBrowse link
G Nr2c2 nuclear receptor subfamily 2 group C member 2 involved_in ISO (MGI:5320687|PMID:22337877) CACAO PMID:22337877 MGI:5320687 NCBI chrNW_004936602:491,821...557,790
Ensembl chrNW_004936602:504,652...553,936 		JBrowse link
G Zfp36 ZFP36 ring finger protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936661:2,251,148...2,253,527
Ensembl chrNW_004936661:2,250,665...2,253,787 		JBrowse link
G Zfp36l1 ZFP36 ring finger protein like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936495:12,045,679...12,050,737
Ensembl chrNW_004936495:12,045,377...12,051,536 		JBrowse link
negative regulation of p38MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyld CYLD lysine 63 deubiquitinase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:3,750,917...3,812,118
Ensembl chrNW_004936475:3,750,882...3,812,118 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936833:551,989...843,064
Ensembl chrNW_004936833:551,799...844,121 		JBrowse link
G Dusp1 dual specificity phosphatase 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936609:2,688,170...2,691,057
Ensembl chrNW_004936609:2,688,181...2,690,408 		JBrowse link
G Dusp10 dual specificity phosphatase 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936650:679,650...718,867
Ensembl chrNW_004936650:679,647...720,038 		JBrowse link
G Ezr ezrin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936489:10,413,374...10,457,771
Ensembl chrNW_004936489:10,412,710...10,458,201 		JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936690:2,180,804...2,232,869
Ensembl chrNW_004936690:2,181,047...2,232,958 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:18,659,725...18,665,406
Ensembl chrNW_004936476:18,659,815...18,663,940 		JBrowse link
positive regulation of p38MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end-product specific receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936727:1,418,342...1,422,005
Ensembl chrNW_004936727:1,418,799...1,422,147 		JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 involved_in ISO (PMID:23389627) AgBase PMID:23389627 NCBI chrNW_004936580:5,213,323...5,230,861
Ensembl chrNW_004936580:5,214,401...5,245,021 		JBrowse link
G Bmp2 bone morphogenetic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:12,428,765...12,439,570
Ensembl chrNW_004936485:12,428,710...12,439,454 		JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936697:1,054,237...1,061,468
Ensembl chrNW_004936697:1,056,636...1,061,468 		JBrowse link
G Gadd45a growth arrest and DNA damage inducible alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936591:3,998,359...4,001,491
Ensembl chrNW_004936591:3,998,340...4,001,830 		JBrowse link
G Gadd45b growth arrest and DNA damage inducible beta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936588:1,476,580...1,479,444
Ensembl chrNW_004936588:1,477,476...1,479,457 		JBrowse link
G Gadd45g growth arrest and DNA damage inducible gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936780:501,452...503,272
Ensembl chrNW_004936780:501,681...503,305 		JBrowse link
G Gdf6 growth differentiation factor 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936470:46,361,528...46,379,576
Ensembl chrNW_004936470:46,361,451...46,377,594 		JBrowse link
G Gsn gelsolin ISO RGD PMID:24505034 RGD:329333013 NCBI chrNW_004936487:9,749,755...9,802,787
Ensembl chrNW_004936487:9,764,944...9,802,841 		JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936516:4,692,926...4,695,625
Ensembl chrNW_004936516:4,692,926...4,695,632 		JBrowse link
G Il1b interleukin 1 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 ISO RGD PMID:28679649 RGD:329955564 NCBI chrNW_004936706:940,585...952,484 JBrowse link
G Lep leptin involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936479:15,394,966...15,411,334
Ensembl chrNW_004936479:15,394,966...15,411,334 		JBrowse link
G Map3k3 mitogen-activated protein kinase kinase kinase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10700190) Ensembl
MGI		 PMID:10700190 GO_REF:0000107 NCBI chrNW_004936541:4,276,371...4,345,239
Ensembl chrNW_004936541:4,276,371...4,344,008 		JBrowse link
G Map3k4 mitogen-activated protein kinase kinase kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936489:11,908,083...11,972,186
Ensembl chrNW_004936489:11,909,922...11,975,715 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO RGD PMID:20716917 RGD:10412640 NCBI chrNW_004936560:3,988,696...4,197,953
Ensembl chrNW_004936560:3,989,420...4,197,501 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase acts_upstream_of_or_within ISO (PMID:23994610) MGI PMID:23994610 NCBI chrNW_004936589:2,280,803...2,390,179
Ensembl chrNW_004936589:2,280,799...2,390,179 		JBrowse link
G Mfhas1 multifunctional ROCO family signaling regulator 1 involved_in ISO (PMID:28471450) UniProt PMID:28471450 NCBI chrNW_004936573:1,567,798...1,662,442 JBrowse link
G Mink1 misshapen like kinase 1 involved_in ISO (MGI:1354211|PMID:10708748) UniProt PMID:10708748 MGI:1354211 NCBI chrNW_004936677:2,813,899...2,864,366
Ensembl chrNW_004936677:2,813,899...2,864,366 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936543:3,617,369...3,630,990
Ensembl chrNW_004936543:3,617,372...3,630,997 		JBrowse link
G Oprk1 opioid receptor kappa 1 ISO RGD PMID:16648139 RGD:9831415 NCBI chrNW_004936496:280,593...305,900
Ensembl chrNW_004936496:280,558...305,904 		JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936531:4,022,175...4,093,404
Ensembl chrNW_004936531:4,021,711...4,068,459 		JBrowse link
G Prmt1 protein arginine methyltransferase 1 involved_in ISO PMID:23483889 BHF-UCL PMID:23483889 RGD:10047341 NCBI chrNW_004936664:3,492,032...3,502,738
Ensembl chrNW_004936664:3,491,920...3,504,667 		JBrowse link
G Rell1 RELT like 1 involved_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936482:5,626,563...5,695,320
Ensembl chrNW_004936482:5,625,349...5,695,360 		JBrowse link
G Rell2 RELT like 2 involved_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936504:12,520,262...12,530,482
Ensembl chrNW_004936504:12,522,701...12,529,954 		JBrowse link
G Sash1 SAM and SH3 domain containing 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23776175) MGI
Ensembl		 PMID:23776175 GO_REF:0000107 NCBI chrNW_004936489:1,569,143...1,740,398
Ensembl chrNW_004936489:1,447,885...1,740,400 		JBrowse link
G Sphk1 sphingosine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936594:1,482,830...1,489,337
Ensembl chrNW_004936594:1,486,111...1,489,188 		JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in ISO (MGI:6478061|PMID:28912174) ARUK-UCL PMID:28912174 MGI:6478061 NCBI chrNW_004936562:1,852,759...1,870,647
Ensembl chrNW_004936562:1,852,740...1,870,472 		JBrowse link
G Stk39 serine/threonine kinase 39 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936469:11,274,398...11,516,244
Ensembl chrNW_004936469:11,274,409...11,516,752 		JBrowse link
G Vegfa vascular endothelial growth factor A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:16,245,134...16,261,180
Ensembl chrNW_004936476:16,247,100...16,260,673 		JBrowse link
G Xdh xanthine dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936493:1,762,814...1,824,501
Ensembl chrNW_004936493:1,762,869...1,823,238 		JBrowse link
G Zc3h12a zinc finger CCCH-type containing 12A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:19,714,145...19,722,512
Ensembl chrNW_004936474:19,714,153...19,722,528 		JBrowse link
regulation of p38MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end-product specific receptor involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936727:1,418,342...1,422,005
Ensembl chrNW_004936727:1,418,799...1,422,147 		JBrowse link
G Cav3 caveolin 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21182936) Ensembl
MGI		 PMID:21182936 GO_REF:0000107 NCBI chrNW_004936602:4,264,896...4,278,160
Ensembl chrNW_004936602:4,264,889...4,278,161 		JBrowse link
G Dab2ip DAB2 interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:10,056,809...10,243,021
Ensembl chrNW_004936487:10,145,278...10,243,174 		JBrowse link
G Hgf hepatocyte growth factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23994610) Ensembl
MGI		 PMID:23994610 GO_REF:0000107 NCBI chrNW_004936734:354,798...428,356
Ensembl chrNW_004936734:356,115...428,779 		JBrowse link
G Lgals9 galectin 9 NOT|involved_in ISO (PMID:24465902) UniProt PMID:24465902 NCBI chrNW_004936538:4,034,467...4,050,240 JBrowse link
G Per1 period circadian regulator 1 involved_in ISO PMID:24447840 UniProt PMID:24447840 RGD:8655527 NCBI chrNW_004936595:1,366,883...1,382,138
Ensembl chrNW_004936595:1,366,875...1,382,170 		JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936497:2,467,776...2,683,794
Ensembl chrNW_004936497:2,467,684...2,683,799 		JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 NOT|involved_in ISO (PMID:19933860) UniProt PMID:19933860 NCBI chrNW_004936471:2,152,231...2,222,260
Ensembl chrNW_004936471:2,153,880...2,222,229 		JBrowse link
G Trpv4 transient receptor potential cation channel subfamily V member 4 NOT|involved_in ISO (MGI:5440106|PMID:23021218) UniProt PMID:23021218 MGI:5440106 NCBI chrNW_004936769:1,424,526...1,447,547
Ensembl chrNW_004936769:1,424,549...1,447,516 		JBrowse link
G Ulk4 unc-51 like kinase 4 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:24284070) MGI
Ensembl		 PMID:24284070 GO_REF:0000107 NCBI chrNW_004936473:30,034,159...30,536,450
Ensembl chrNW_004936473:30,038,164...30,536,567 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15975
    cellular process 15076
      signal transduction 5693
        intracellular signal transduction 2556
          intracellular signaling cassette 1777
            MAPK cascade 735
              p38MAPK cascade 63
                negative regulation of p38MAPK cascade 7
                positive regulation of p38MAPK cascade 32
                regulation of p38MAPK cascade + 48
Path 2
Term Annotations click to browse term
  biological_process 15975
    biological regulation 11163
      regulation of biological process 10823
        signaling 6182
          signal transduction 5693
            intracellular signal transduction 2556
              intracellular signaling cassette 1777
                MAPK cascade 735
                  p38MAPK cascade 63
                    negative regulation of p38MAPK cascade 7
                    positive regulation of p38MAPK cascade 32
                    regulation of p38MAPK cascade + 48
paths to the root