Spi1 (Spi-1 proto-oncogene) - Rat Genome Database

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Gene: Spi1 (Spi-1 proto-oncogene) Ictidomys tridecemlineatus
Analyze
Symbol: Spi1
Name: Spi-1 proto-oncogene
RGD ID: 12678963
Description: ENCODES a protein that exhibits chromatin binding (ortholog); cis-regulatory region sequence-specific DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN anatomical structure regression (ortholog); apoptotic process involved in blood vessel morphogenesis (ortholog); cellular response to ethanol (ortholog); PARTICIPATES IN DNA modification pathway; interleukin-4 signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); alcohol use disorder (ortholog); congenital disorder of glycosylation type IIc (ortholog); FOUND IN chromatin (ortholog); nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: Spi-1 proto-oncogene, transcript variant X1; Spi-1 proto-oncogene, transcript variant X2; spleen focus forming virus (SFFV) proviral integration oncogene; transcription factor PU.1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,741,101 - 19,757,903 (+)NCBI
SpeTri2.0NW_0049365621,852,759 - 1,870,647 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure regression  (ISO)
apoptotic process involved in blood vessel morphogenesis  (ISO)
cellular response to ethanol  (ISO)
defense response to tumor cell  (ISO)
endothelial to hematopoietic transition  (ISO)
erythrocyte differentiation  (ISO)
follicular B cell differentiation  (ISO)
germinal center B cell differentiation  (ISO)
granulocyte differentiation  (ISO)
histone H3 acetylation  (ISO)
hypermethylation of CpG island  (ISO)
immature B cell differentiation  (ISO)
interleukin-6-mediated signaling pathway  (ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
lymphocyte differentiation  (ISO)
lymphoid progenitor cell differentiation  (ISO)
macrophage differentiation  (ISO)
myeloid dendritic cell differentiation  (ISO)
myeloid leukocyte differentiation  (ISO)
negative regulation of adipose tissue development  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of gene expression, epigenetic  (ISO)
negative regulation of histone H4 acetylation  (ISO)
negative regulation of MHC class II biosynthetic process  (ISO)
negative regulation of neutrophil degranulation  (ISO)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of NIK/NF-kappaB signaling  (ISO)
negative regulation of protein localization to chromatin  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
oncogene-induced cell senescence  (ISO)
pericyte cell differentiation  (ISO)
positive regulation of antifungal innate immune response  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of microglial cell mediated cytotoxicity  (ISO)
positive regulation of myeloid dendritic cell chemotaxis  (ISO)
positive regulation of p38MAPK cascade  (ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
pro-T cell differentiation  (ISO)
regulation of DNA-binding transcription factor activity  (ISO)
regulation of erythrocyte differentiation  (ISO)
regulation of histone H3-K27 acetylation  (ISO)
regulation of myeloid progenitor cell differentiation  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (ISO)
somatic stem cell population maintenance  (ISO)
TRAIL-activated apoptotic signaling pathway  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
vasculature development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Spi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,741,101 - 19,757,903 (+)NCBI
SpeTri2.0NW_0049365621,852,759 - 1,870,647 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1147,354,860 - 47,378,547 (-)EnsemblGRCh38hg38GRCh38
GRCh381147,354,859 - 47,395,640 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371147,376,411 - 47,400,098 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,332,985 - 47,356,703 (-)NCBINCBI36hg18NCBI36
Build 341147,332,987 - 47,356,674NCBI
Celera1147,515,686 - 47,541,505 (-)NCBI
Cytogenetic Map11p11.2NCBI
HuRef1147,075,532 - 47,099,721 (-)NCBIHuRef
CHM1_11147,375,652 - 47,399,367 (-)NCBICHM1_1
Spi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39290,912,750 - 90,946,104 (+)NCBIGRCm39mm39
GRCm39 Ensembl290,912,735 - 90,946,101 (+)Ensembl
GRCm38291,082,374 - 91,115,759 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,082,390 - 91,115,756 (+)EnsemblGRCm38mm10GRCm38
MGSCv37290,936,954 - 90,955,913 (+)NCBIGRCm37mm9NCBIm37
MGSCv36290,897,636 - 90,916,595 (+)NCBImm8
Celera292,481,297 - 92,500,928 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.44NCBI
Spi1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2377,059,744 - 77,093,730 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl377,073,012 - 77,092,393 (+)Ensembl
Rnor_6.0379,918,127 - 79,937,708 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,918,969 - 79,938,301 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0386,627,684 - 86,646,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,456,353 - 75,475,722 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1375,352,724 - 75,372,093 (+)NCBI
Celera376,282,068 - 76,300,680 (+)NCBICelera
Cytogenetic Map3q24NCBI
Spi1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422873,735 - 886,560 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955422873,735 - 886,560 (+)NCBIChiLan1.0ChiLan1.0
SPI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11147,853,991 - 47,880,259 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,853,991 - 47,880,259 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01147,301,245 - 47,326,891 (-)NCBIMhudiblu_PPA_v0panPan3
SPI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,253,849 - 42,269,497 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,253,811 - 42,269,727 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1840,983,530 - 40,999,141 (+)NCBI
ROS_Cfam_1.01842,908,919 - 42,924,536 (+)NCBI
UMICH_Zoey_3.11842,395,271 - 42,410,877 (+)NCBI
UNSW_CanFamBas_1.01841,950,490 - 41,966,095 (+)NCBI
UU_Cfam_GSD_1.01842,679,725 - 42,695,395 (+)NCBI
SPI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,227,829 - 15,245,667 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,227,850 - 15,245,679 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,434,712 - 16,452,518 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,935,037 - 17,961,638 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl117,935,922 - 17,961,717 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038115,237,583 - 115,263,142 (+)NCBIVero_WHO_p1.0
Spi1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247671,376,649 - 1,404,382 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005329981   ⟹   XP_005330038
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494719,741,101 - 19,757,903 (+)NCBI
SpeTri2.0NW_0049365621,852,759 - 1,870,647 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005329982   ⟹   XP_005330039
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494719,741,101 - 19,757,903 (+)NCBI
SpeTri2.0NW_0049365621,852,759 - 1,870,647 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005330038 (Get FASTA)   NCBI Sequence Viewer  
  XP_005330039 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3285333 (Get FASTA)   NCBI Sequence Viewer  
  KAG3285334 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005330038   ⟸   XM_005329981
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005330039   ⟸   XM_005329982
- Peptide Label: isoform X2
- UniProtKB: I3N9N7 (UniProtKB/TrEMBL)
- Sequence:


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000022735 ENTREZGENE
Ensembl Protein ENSSTOP00000021084 ENTREZGENE
NCBI Gene Spi1 ENTREZGENE
UniProt I3N9N7 ENTREZGENE