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Gene: Gadd45a (growth arrest and DNA damage inducible alpha) Ictidomys tridecemlineatus

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Symbol:

Gadd45a

Name:

growth arrest and DNA damage inducible alpha

RGD ID:

12731522

Description:

ENCODES a protein that exhibits kinase binding (inferred); promoter-specific chromatin binding (inferred); protein heterodimerization activity (inferred); INVOLVED IN centrosome cycle (ortholog); G2/M transition of mitotic cell cycle (ortholog); negative regulation of peptidyl-serine phosphorylation of STAT protein (ortholog); PARTICIPATES IN p38 MAPK signaling pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Chloracne (ortholog); human immunodeficiency virus infectious disease (ortholog); FOUND IN cytoplasm (inferred); nuclear speck (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

growth arrest and DNA damage-inducible protein GADD45 alpha

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	80,488,019 - 80,491,186 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936591	3,998,340 - 4,001,830 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936591	3,998,359 - 4,001,491 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (ISO)

Chloracne (ISO)

human immunodeficiency virus infectious disease (ISO)

intellectual disability (ISO)

juvenile rheumatoid arthritis (ISO)

Ovarian Neoplasms (ISO)

pancreatic cancer (ISO)

Prostatic Neoplasms (ISO)

Stomach Neoplasms (ISO)

systemic lupus erythematosus (ISO)

Ventilator-Induced Lung Injury (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to ionizing radiation (IEA)

cellular response to mechanical stimulus (IEA)

centrosome cycle (IEA,ISO)

DNA damage response (IEA)

G2/M transition of mitotic cell cycle (ISO)

negative regulation of angiogenesis (IEA)

negative regulation of blood vessel endothelial cell migration (IEA)

negative regulation of peptidyl-serine phosphorylation of STAT protein (ISO)

negative regulation of protein kinase activity (ISO)

negative regulation of protein serine/threonine kinase activity (ISO)

negative regulation of transcription by RNA polymerase II (IEA)

positive regulation of apoptotic process (IEA)

positive regulation of JNK cascade (IEA)

positive regulation of p38MAPK cascade (IEA)

positive regulation of reactive oxygen species metabolic process (IEA)

regulation of cell cycle (IEA,ISO)

signal transduction in response to DNA damage (IEA)

Cellular Component

cytoplasm (IEA)

nuclear speck (IEA)

nucleus (IEA)

Molecular Function

kinase binding (IEA)

promoter-specific chromatin binding (IEA)

protein binding (ISO)

protein heterodimerization activity (IEA)

protein homodimerization activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

p38 MAPK signaling pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Gadd45a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	80,488,019 - 80,491,186 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936591	3,998,340 - 4,001,830 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936591	3,998,359 - 4,001,491 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GADD45A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	67,685,201 - 67,688,334 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	67,685,201 - 67,688,334 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	68,150,884 - 68,154,017 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	67,923,471 - 67,926,607 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	67,862,903 - 67,866,040	NCBI
Celera	1	66,441,746 - 66,444,882 (+)	NCBI		Celera
Cytogenetic Map	1	p31.3	NCBI
HuRef	1	66,261,120 - 66,264,281 (+)	NCBI		HuRef
CHM1_1	1	68,265,339 - 68,268,500 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	67,562,720 - 67,565,853 (+)	NCBI		T2T-CHM13v2.0

Gadd45a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	67,012,080 - 67,014,391 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	67,012,080 - 67,014,441 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	67,035,096 - 67,037,407 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	67,035,096 - 67,037,457 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	66,985,090 - 66,987,401 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	66,964,674 - 66,966,985 (-)	NCBI		MGSCv36	mm8
Celera	6	69,156,594 - 69,158,906 (-)	NCBI		Celera
Cytogenetic Map	6	C1	NCBI
cM Map	6	30.72	NCBI

Gadd45a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	97,484,497 - 97,486,799 (-)	NCBI		GRCr8
mRatBN7.2	4	96,154,789 - 96,157,091 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	96,154,789 - 96,157,115 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	101,404,229 - 101,406,531 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	97,179,202 - 97,181,504 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	95,604,320 - 95,606,622 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	97,782,512 - 97,784,814 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	97,782,512 - 97,784,842 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	162,568,472 - 162,570,774 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	96,649,941 - 96,652,243 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	96,894,423 - 96,896,724 (-)	NCBI
Celera	4	90,851,517 - 90,853,819 (-)	NCBI		Celera
Cytogenetic Map	4	q31	NCBI

Gadd45a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	23,656,458 - 23,658,367 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955423	23,656,516 - 23,658,367 (-)	NCBI	ChiLan1.0	ChiLan1.0

GADD45A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	159,181,009 - 159,184,168 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	158,340,738 - 158,343,876 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	66,925,063 - 66,928,222 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	68,880,912 - 68,884,188 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	68,880,912 - 68,884,188 (+)	Ensembl	panpan1.1		panPan2

GADD45A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	77,393,026 - 77,396,473 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	77,393,036 - 77,396,618 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	80,002,561 - 80,006,283 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	77,992,921 - 77,996,356 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	77,992,931 - 77,996,499 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	77,573,227 - 77,576,562 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	77,441,881 - 77,445,351 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	77,928,564 - 77,931,987 (-)	NCBI		UU_Cfam_GSD_1.0

GADD45A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	144,940,697 - 144,944,089 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	144,940,702 - 144,944,089 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

GADD45A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	65,422,668 - 65,425,845 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	65,422,451 - 65,425,840 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	52,186,272 - 52,189,568 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gadd45a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	27,727,660 - 27,730,316 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624742	27,727,801 - 27,730,252 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005332362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000019378 ⟹ ENSSTOP00000021508

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936591	3,998,340 - 4,001,830 (-)	Ensembl

Ensembl Acc Id:

ENSSTOT00000034653 ⟹ ENSSTOP00000026084

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936591	3,998,930 - 4,001,200 (-)	Ensembl

Ensembl Acc Id:

ENSSTOT00000042508 ⟹ ENSSTOP00000024746

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936591	3,999,007 - 4,001,200 (-)	Ensembl

RefSeq Acc Id:

XM_005332362 ⟹ XP_005332419

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	80,488,019 - 80,491,186 (+)	NCBI
SpeTri2.0	NW_004936591	3,998,359 - 4,001,491 (-)	NCBI

Sequence:

show sequence

TTGTCCTCCAGTGGCTGTGAGGCAGCTGCGGTAGAGGCGTCGTGGTACACTTCTAGGCTAGGGC
CCGCAAGCGACGGGGCGAGCCAGCAAGCGGGGCGGGAAGGGAGCACGGCGCAGCAGCGGCGGGC
GCTGGTGGAGGAGCCCGGGAGGGCGAGGGGCGGTCGGACTGCGTCGGATCGGAGCGCGCTACAG
GAAGCCTGAGAGCGAGTGCAGAGAGCTGGCGCCCGCGCGCCCACGGTGGCCGGAGCAGCCCGCA
CGCCGCGCTCTCTGTGAGGGACTTGCAGTTGCAATATGACTTTGGAAGAATTCTCGGCTGGAGA
GCAAAAGACCGAAAGGATGGACAAGGTGGGCGATGCCCTGGAGGAAGTGCTCAGCAAAGCCCTG
AGTCAGCGTACCATCACAGTCGGGGTGTACGAGGCGGCGAAGCTGCTCAACGTCGACCCGGATA
ATGTGGTTCTGTGCCTGCTGGCGGCAGACGAGGACGACGACAGGGATGTGGCTCTGCAGATCCA
CTTCACTCTGATCCAGGCGTTCTGCTGTGAGAACGACATTAACATCCTGCGCGTCAGCAACCCG
GGCCGGCTGGCAGAGCTCCTGCTGCTGGAGACCGACGGGAGCCCAGCTGCAAGCGAGGGCGCAG
CGCAGCCTCCGGACCTGCACTGCGTGCTGGTTACGAATCCACATTCATCACAATGGAAGGATCC
TGCCTTAAGTCAACTTATTTGTTTCTGCCGAGAAAGTCGCTACATGGATCAGTGGGTTCCAGTG
ATTAATCTCCCTGAACGGTGATGGCATCTGAATGAAAATAACTAAACCAAATTGCACTGAAGTT
TTGAAATACCTTTGTAGTTACTCAAGCAGTTACTCCCTACACTGATGCAAGGATTACAGAAACT
GATGTCAAGGGGCTGAGTGAGTTCAACTACATGTTCTGGGGGCCCAGAGATAGATGACTTTGCA
GATGGAAAGAGGTGAAAATGAAGAAACAAGCTGTGTTGAAACAAATAAAAGTCAAAAGGAACAA
AAATTACAGAGAACCACGTGGGAAGGAAAACTATGTATTAATTTAGGATGGTTGAGTTACATTA
AAATAAACCAAATATGCTTTGTTAAAGTTTAAATGTGCAGCAGTAGTTTGGGTATTTTGGTTTA
TATTCCCTCCCTCAAGTTAAAAAAAAAAAACTGAAAGGGTTAATCATATTTTAAAACCATATTT
TATTGTATTTTGATGAGATGTTAAATTCTCAAAAGTTTTATTATAATTGTACTAAGTTATTTTA
TGACATGAAAGGTTATTTATGCTATAAATTTTTTGAAACAATACCTACAATAAACTGATGTGGA
ATAATTGCATCATTTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005332419	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000021508.1
	ENSSTOP00000024746.1
	ENSSTOP00000026084.1
GenBank Protein	KAG3283358	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005332419 ⟸ XM_005332362
- UniProtKB:	I3NAW1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTLEEFSAGEQKTERMDKVGDALEEVLSKALSQRTITVGVYEAAKLLNVDPDNVVLCLLAADED DDRDVALQIHFTLIQAFCCENDINILRVSNPGRLAELLLLETDGSPAASEGAAQPPDLHCVLVT NPHSSQWKDPALSQLICFCRESRYMDQWVPVINLPER hide sequence

Ensembl Acc Id:

ENSSTOP00000026084 ⟸ ENSSTOT00000034653

Ensembl Acc Id:

ENSSTOP00000024746 ⟸ ENSSTOT00000042508

Ensembl Acc Id:

ENSSTOP00000021508 ⟸ ENSSTOT00000019378

Protein Domains

Ribosomal protein eL8/eL30/eS12/Gadd45

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000024503	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000019378.2	UniProtKB/TrEMBL
	ENSSTOT00000034653.1	UniProtKB/TrEMBL
	ENSSTOT00000042508.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.1330.30	UniProtKB/TrEMBL
InterPro	GADD45	UniProtKB/TrEMBL
	L30e-like	UniProtKB/TrEMBL
	Ribosomal_L7Ae/L30e/S12e/Gad45	UniProtKB/TrEMBL
NCBI Gene	Gadd45a	ENTREZGENE
PANTHER	GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA	UniProtKB/TrEMBL
	PTHR10411	UniProtKB/TrEMBL
Pfam	Ribosomal_L7Ae	UniProtKB/TrEMBL
Superfamily-SCOP	SSF55315	UniProtKB/TrEMBL
UniProt	A0A287CTY5_ICTTR	UniProtKB/TrEMBL
	A0A287CXV1_ICTTR	UniProtKB/TrEMBL
	I3NAW1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Annotations - PID (archival)