GADD45A (growth arrest and DNA damage inducible alpha) - Rat Genome Database

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Gene: GADD45A (growth arrest and DNA damage inducible alpha) Canis lupus familiaris
Analyze
Symbol: GADD45A
Name: growth arrest and DNA damage inducible alpha
RGD ID: 12409625
Description: ENCODES a protein that exhibits kinase binding (ortholog); promoter-specific chromatin binding (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN cellular response to ionizing radiation (ortholog); cellular response to mechanical stimulus (ortholog); centrosome cycle (ortholog); PARTICIPATES IN p38 MAPK signaling pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Chloracne (ortholog); human immunodeficiency virus infectious disease (ortholog); FOUND IN cytoplasm (ortholog); nuclear speck (ortholog); INTERACTS WITH tert-butyl hydroperoxide
Type: protein-coding
RefSeq Status: MODEL
Previously known as: growth arrest and DNA damage-inducible protein GADD45 alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1677,393,026 - 77,396,473 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl677,393,036 - 77,396,618 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha680,002,561 - 80,006,283 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0677,992,921 - 77,996,356 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl677,992,931 - 77,996,499 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1677,573,227 - 77,576,562 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0677,441,881 - 77,445,351 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0677,928,564 - 77,931,987 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
nuclear speck  (ISO)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
GADD45A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1677,393,026 - 77,396,473 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl677,393,036 - 77,396,618 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha680,002,561 - 80,006,283 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0677,992,921 - 77,996,356 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl677,992,931 - 77,996,499 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1677,573,227 - 77,576,562 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0677,441,881 - 77,445,351 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0677,928,564 - 77,931,987 (-)NCBIUU_Cfam_GSD_1.0
GADD45A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38167,685,201 - 67,688,334 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl167,685,201 - 67,688,334 (+)EnsemblGRCh38hg38GRCh38
GRCh37168,150,884 - 68,154,017 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36167,923,471 - 67,926,607 (+)NCBINCBI36Build 36hg18NCBI36
Build 34167,862,903 - 67,866,040NCBI
Celera166,441,746 - 66,444,882 (+)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef166,261,120 - 66,264,281 (+)NCBIHuRef
CHM1_1168,265,339 - 68,268,500 (+)NCBICHM1_1
T2T-CHM13v2.0167,562,720 - 67,565,853 (+)NCBIT2T-CHM13v2.0
Gadd45a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39667,012,080 - 67,014,391 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl667,012,080 - 67,014,441 (-)EnsemblGRCm39 Ensembl
GRCm38667,035,096 - 67,037,407 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl667,035,096 - 67,037,457 (-)EnsemblGRCm38mm10GRCm38
MGSCv37666,985,090 - 66,987,401 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36666,964,674 - 66,966,985 (-)NCBIMGSCv36mm8
Celera669,156,594 - 69,158,906 (-)NCBICelera
Cytogenetic Map6C1NCBI
cM Map630.72NCBI
Gadd45a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8497,484,497 - 97,486,799 (-)NCBIGRCr8
mRatBN7.2496,154,789 - 96,157,091 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl496,154,789 - 96,157,115 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4101,404,229 - 101,406,531 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0497,179,202 - 97,181,504 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0495,604,320 - 95,606,622 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0497,782,512 - 97,784,814 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl497,782,512 - 97,784,842 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04162,568,472 - 162,570,774 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4496,649,941 - 96,652,243 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1496,894,423 - 96,896,724 (-)NCBI
Celera490,851,517 - 90,853,819 (-)NCBICelera
Cytogenetic Map4q31NCBI
Gadd45a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542323,656,458 - 23,658,367 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542323,656,516 - 23,658,367 (-)NCBIChiLan1.0ChiLan1.0
GADD45A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21159,181,009 - 159,184,168 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11158,340,738 - 158,343,876 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0166,925,063 - 66,928,222 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1168,880,912 - 68,884,188 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl168,880,912 - 68,884,188 (+)Ensemblpanpan1.1panPan2
Gadd45a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505880,488,019 - 80,491,186 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365913,998,340 - 4,001,830 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365913,998,359 - 4,001,491 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GADD45A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6144,940,697 - 144,944,089 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16144,940,702 - 144,944,089 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GADD45A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12065,422,668 - 65,425,845 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2065,422,451 - 65,425,840 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603352,186,272 - 52,189,568 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gadd45a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474227,727,660 - 27,730,316 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474227,727,801 - 27,730,252 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GADD45A
33 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000046905   ⟹   ENSCAFP00000036046
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl677,393,036 - 77,396,618 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000063186   ⟹   ENSCAFP00000046669
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl677,393,483 - 77,396,618 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000068600   ⟹   ENSCAFP00000058390
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl677,393,036 - 77,395,709 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000087924   ⟹   ENSCAFP00000066209
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl677,393,673 - 77,396,480 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845025113   ⟹   ENSCAFP00845019752
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl677,992,931 - 77,996,499 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845025123   ⟹   ENSCAFP00845019759
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl677,992,931 - 77,996,499 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845025137   ⟹   ENSCAFP00845019770
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl677,993,568 - 77,996,353 (-)Ensembl
RefSeq Acc Id: XM_038480457   ⟹   XP_038336385
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1677,573,227 - 77,576,562 (-)NCBI
RefSeq Acc Id: XM_038535536   ⟹   XP_038391464
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha680,002,561 - 80,006,283 (-)NCBI
RefSeq Acc Id: XM_038538927   ⟹   XP_038394855
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0677,928,564 - 77,931,987 (-)NCBI
RefSeq Acc Id: XM_038603054   ⟹   XP_038458982
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0677,441,881 - 77,445,351 (-)NCBI
RefSeq Acc Id: XM_038670428   ⟹   XP_038526356
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0677,992,921 - 77,996,356 (-)NCBI
Ensembl Acc Id: ENSCAFP00000046669   ⟸   ENSCAFT00000063186
Ensembl Acc Id: ENSCAFP00000066209   ⟸   ENSCAFT00000087924
Ensembl Acc Id: ENSCAFP00000058390   ⟸   ENSCAFT00000068600
Ensembl Acc Id: ENSCAFP00000036046   ⟸   ENSCAFT00000046905
RefSeq Acc Id: XP_038336385   ⟸   XM_038480457
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038458982   ⟸   XM_038603054
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038526356   ⟸   XM_038670428
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N5M6 (UniProtKB/TrEMBL),   A0A8C0KYD5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038391464   ⟸   XM_038535536
- Peptide Label: isoform X2
- UniProtKB: A0A8P0P7I3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038394855   ⟸   XM_038538927
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KYD5 (UniProtKB/TrEMBL),   A0A8C0N5M6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845019752   ⟸   ENSCAFT00845025113
Ensembl Acc Id: ENSCAFP00845019770   ⟸   ENSCAFT00845025137
Ensembl Acc Id: ENSCAFP00845019759   ⟸   ENSCAFT00845025123
Protein Domains
Ribosomal protein eL8/eL30/eS12/Gadd45

Promoters
RGD ID:13683853
Promoter ID:EPDNEW_C1921
Type:single initiation site
Name:GADD45A_1
Description:growth arrest and DNA damage inducible alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1677,396,488 - 77,396,548EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000029474 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013481 UniProtKB/TrEMBL
  ENSCAFG00040002260 UniProtKB/TrEMBL
  ENSCAFG00845014040 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000046905.3 UniProtKB/TrEMBL
  ENSCAFT00000068600.2 UniProtKB/TrEMBL
  ENSCAFT00030024993.1 UniProtKB/TrEMBL
  ENSCAFT00030025039.1 UniProtKB/TrEMBL
  ENSCAFT00030025091.1 UniProtKB/TrEMBL
  ENSCAFT00030025110.1 UniProtKB/TrEMBL
  ENSCAFT00040004288.1 UniProtKB/TrEMBL
  ENSCAFT00040004302.1 UniProtKB/TrEMBL
  ENSCAFT00040004316.1 UniProtKB/TrEMBL
  ENSCAFT00040004326.1 UniProtKB/TrEMBL
  ENSCAFT00845025113.1 UniProtKB/TrEMBL
  ENSCAFT00845025123.1 UniProtKB/TrEMBL
  ENSCAFT00845025137.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1330.30 UniProtKB/TrEMBL
InterPro GADD45 UniProtKB/TrEMBL
  L30e-like UniProtKB/TrEMBL
  Ribosomal_L7Ae/L30e/S12e/Gad45 UniProtKB/TrEMBL
NCBI Gene GADD45A ENTREZGENE
PANTHER GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA UniProtKB/TrEMBL
  PTHR10411 UniProtKB/TrEMBL
Pfam Ribosomal_L7Ae UniProtKB/TrEMBL
PRINTS PRICHEXTENSN UniProtKB/TrEMBL
Superfamily-SCOP SSF55315 UniProtKB/TrEMBL
UniProt A0A8C0KYD5 ENTREZGENE
  A0A8C0N5M6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0NAU4_CANLF UniProtKB/TrEMBL
  A0A8C0RJF6_CANLF UniProtKB/TrEMBL
  A0A8C0RW67_CANLF UniProtKB/TrEMBL
  A0A8I3NP94_CANLF UniProtKB/TrEMBL
  A0A8I3NSC4_CANLF UniProtKB/TrEMBL
  A0A8I3S0K2_CANLF UniProtKB/TrEMBL
  A0A8P0P7I3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SR92_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:41069 ENTREZGENE