GADD45A (growth arrest and DNA damage inducible alpha) - Rat Genome Database

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Gene: GADD45A (growth arrest and DNA damage inducible alpha) Canis lupus familiaris
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Symbol: GADD45A
Name: growth arrest and DNA damage inducible alpha
RGD ID: 12409625
Description: ENCODES a protein that exhibits promoter-specific chromatin binding (ortholog); INVOLVED IN centrosome cycle (ortholog); G2/M transition of mitotic cell cycle (ortholog); negative regulation of angiogenesis (ortholog); PARTICIPATES IN p38 MAPK signaling pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Chloracne (ortholog); human immunodeficiency virus infectious disease (ortholog); FOUND IN cytoplasm (ortholog); INTERACTS WITH tert-butyl hydroperoxide
Type: protein-coding
RefSeq Status: MODEL
Previously known as: growth arrest and DNA damage-inducible protein GADD45 alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1677,393,026 - 77,396,473 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl677,393,036 - 77,396,618 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha680,002,561 - 80,006,283 (-)NCBI
ROS_Cfam_1.0677,992,921 - 77,996,356 (-)NCBI
ROS_Cfam_1.0 Ensembl677,992,931 - 77,996,499 (-)Ensembl
UMICH_Zoey_3.1677,573,227 - 77,576,562 (-)NCBI
UNSW_CanFamBas_1.0677,441,881 - 77,445,351 (-)NCBI
UU_Cfam_GSD_1.0677,928,564 - 77,931,987 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
GADD45A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1677,393,026 - 77,396,473 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl677,393,036 - 77,396,618 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha680,002,561 - 80,006,283 (-)NCBI
ROS_Cfam_1.0677,992,921 - 77,996,356 (-)NCBI
ROS_Cfam_1.0 Ensembl677,992,931 - 77,996,499 (-)Ensembl
UMICH_Zoey_3.1677,573,227 - 77,576,562 (-)NCBI
UNSW_CanFamBas_1.0677,441,881 - 77,445,351 (-)NCBI
UU_Cfam_GSD_1.0677,928,564 - 77,931,987 (-)NCBI
GADD45A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38167,685,201 - 67,688,334 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl167,685,201 - 67,688,334 (+)EnsemblGRCh38hg38GRCh38
GRCh37168,150,884 - 68,154,017 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36167,923,471 - 67,926,607 (+)NCBINCBI36hg18NCBI36
Build 34167,862,903 - 67,866,040NCBI
Celera166,441,746 - 66,444,882 (+)NCBI
Cytogenetic Map1p31.3NCBI
HuRef166,261,120 - 66,264,281 (+)NCBIHuRef
CHM1_1168,265,339 - 68,268,500 (+)NCBICHM1_1
T2T-CHM13v2.0167,562,720 - 67,565,853 (+)NCBI
Gadd45a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39667,012,080 - 67,014,391 (-)NCBIGRCm39mm39
GRCm39 Ensembl667,012,080 - 67,014,441 (-)Ensembl
GRCm38667,035,096 - 67,037,407 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl667,035,096 - 67,037,457 (-)EnsemblGRCm38mm10GRCm38
MGSCv37666,985,090 - 66,987,401 (-)NCBIGRCm37mm9NCBIm37
MGSCv36666,964,674 - 66,966,985 (-)NCBImm8
Celera669,156,594 - 69,158,906 (-)NCBICelera
Cytogenetic Map6C1NCBI
Gadd45a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2496,154,789 - 96,157,091 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl496,154,789 - 96,157,115 (-)Ensembl
Rnor_6.0497,782,512 - 97,784,814 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl497,782,512 - 97,784,842 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04162,568,472 - 162,570,774 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4496,649,941 - 96,652,243 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1496,894,423 - 96,896,724 (-)NCBI
Celera490,851,517 - 90,853,819 (-)NCBICelera
Cytogenetic Map4q31NCBI
Gadd45a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542323,656,458 - 23,658,367 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542323,656,516 - 23,658,367 (-)NCBIChiLan1.0ChiLan1.0
GADD45A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1168,880,912 - 68,884,188 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl168,880,912 - 68,884,188 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0166,925,063 - 66,928,222 (+)NCBIMhudiblu_PPA_v0panPan3
Gadd45a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505880,488,019 - 80,491,186 (+)NCBI
SpeTri2.0NW_0049365913,998,359 - 4,001,491 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GADD45A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6144,940,697 - 144,944,089 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16144,940,702 - 144,944,089 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GADD45A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12065,422,668 - 65,425,845 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2065,422,451 - 65,425,840 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603352,186,272 - 52,189,568 (+)NCBIVero_WHO_p1.0
Gadd45a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474227,727,660 - 27,730,316 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462474227,727,801 - 27,730,252 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 10 6
Low 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000046905   ⟹   ENSCAFP00000036046
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl677,393,036 - 77,396,618 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000063186   ⟹   ENSCAFP00000046669
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl677,393,483 - 77,396,618 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000068600   ⟹   ENSCAFP00000058390
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl677,393,036 - 77,395,709 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000087924   ⟹   ENSCAFP00000066209
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl677,393,673 - 77,396,480 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845025113   ⟹   ENSCAFP00845019752
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl677,992,931 - 77,996,499 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845025123   ⟹   ENSCAFP00845019759
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl677,992,931 - 77,996,499 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845025137   ⟹   ENSCAFP00845019770
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl677,993,568 - 77,996,353 (-)Ensembl
RefSeq Acc Id: XM_003639101   ⟹   XP_003639149
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1677,393,026 - 77,396,473 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038480457   ⟹   XP_038336385
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1677,573,227 - 77,576,562 (-)NCBI
RefSeq Acc Id: XM_038535536   ⟹   XP_038391464
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha680,002,561 - 80,006,283 (-)NCBI
RefSeq Acc Id: XM_038538927   ⟹   XP_038394855
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0677,928,564 - 77,931,987 (-)NCBI
RefSeq Acc Id: XM_038603054   ⟹   XP_038458982
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0677,441,881 - 77,445,351 (-)NCBI
RefSeq Acc Id: XM_038670428   ⟹   XP_038526356
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0677,992,921 - 77,996,356 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_003639149   ⟸   XM_003639101
- Sequence:
RefSeq Acc Id: ENSCAFP00000046669   ⟸   ENSCAFT00000063186
RefSeq Acc Id: ENSCAFP00000066209   ⟸   ENSCAFT00000087924
RefSeq Acc Id: ENSCAFP00000058390   ⟸   ENSCAFT00000068600
RefSeq Acc Id: ENSCAFP00000036046   ⟸   ENSCAFT00000046905
RefSeq Acc Id: XP_038336385   ⟸   XM_038480457
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038458982   ⟸   XM_038603054
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038526356   ⟸   XM_038670428
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038391464   ⟸   XM_038535536
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038394855   ⟸   XM_038538927
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845019752   ⟸   ENSCAFT00845025113
RefSeq Acc Id: ENSCAFP00845019770   ⟸   ENSCAFT00845025137
RefSeq Acc Id: ENSCAFP00845019759   ⟸   ENSCAFT00845025123
Protein Domains
Ribosomal_L7Ae

Promoters
RGD ID:13683853
Promoter ID:EPDNEW_C1921
Type:single initiation site
Name:GADD45A_1
Description:growth arrest and DNA damage inducible alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1677,396,488 - 77,396,548EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000029474 Ensembl
  ENSCAFG00030013481 UniProtKB/TrEMBL
  ENSCAFG00040002260 UniProtKB/TrEMBL
  ENSCAFG00845014040 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030021828.1 UniProtKB/TrEMBL
  ENSCAFP00030021863.1 UniProtKB/TrEMBL
  ENSCAFP00030021904.1 UniProtKB/TrEMBL
  ENSCAFP00030021924.1 UniProtKB/TrEMBL
  ENSCAFP00040003685 UniProtKB/TrEMBL
  ENSCAFP00040003703 UniProtKB/TrEMBL
  ENSCAFP00040003712 UniProtKB/TrEMBL
  ENSCAFP00040003720 UniProtKB/TrEMBL
  ENSCAFP00845019752.1 UniProtKB/TrEMBL
  ENSCAFP00845019759.1 UniProtKB/TrEMBL
  ENSCAFP00845019770.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030024993.1 UniProtKB/TrEMBL
  ENSCAFT00030025039.1 UniProtKB/TrEMBL
  ENSCAFT00030025091.1 UniProtKB/TrEMBL
  ENSCAFT00030025110.1 UniProtKB/TrEMBL
  ENSCAFT00040004288 UniProtKB/TrEMBL
  ENSCAFT00040004302 UniProtKB/TrEMBL
  ENSCAFT00040004316 UniProtKB/TrEMBL
  ENSCAFT00040004326 UniProtKB/TrEMBL
  ENSCAFT00845025113.1 UniProtKB/TrEMBL
  ENSCAFT00845025123.1 UniProtKB/TrEMBL
  ENSCAFT00845025137.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1330.30 UniProtKB/TrEMBL
InterPro GADD45 UniProtKB/TrEMBL
  L30e-like UniProtKB/TrEMBL
  Ribosomal_L7Ae/L30e/S12e/Gad45 UniProtKB/TrEMBL
NCBI Gene GADD45A ENTREZGENE
PANTHER PTHR10411 UniProtKB/TrEMBL
Pfam Ribosomal_L7Ae UniProtKB/TrEMBL
Superfamily-SCOP SSF55315 UniProtKB/TrEMBL
UniProt A0A8C0N5M6_CANLF UniProtKB/TrEMBL
  A0A8C0NAU4_CANLF UniProtKB/TrEMBL
  A0A8C0RJF6_CANLF UniProtKB/TrEMBL
  A0A8C0RW67_CANLF UniProtKB/TrEMBL
  A0A8I3NP94_CANLF UniProtKB/TrEMBL
  A0A8I3NSC4_CANLF UniProtKB/TrEMBL
  A0A8I3S0K2_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:41069 ENTREZGENE