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ONTOLOGY REPORT - ANNOTATIONS

Term:stress-activated protein kinase signaling cascade
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Accession:GO:0031098 term browser browse the term
Definition:The series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays a signal.
Synonyms:exact_synonym: SAPK signaling pathway;   SAPK signalling pathway;   stress-activated protein kinase signaling pathway;   stress-activated protein kinase signalling pathway
 narrow_synonym: JNK signaling pathway;   JNK signalling pathway


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stress-activated protein kinase signaling cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1B1 aldo-keto reductase family 1 member B ISO RGD PMID:16669970 RGD:1626090 NCBI chr 7:126,400,861...126,417,756
Ensembl chr 7:138,912,953...138,924,095 		JBrowse link
G GFRAL GDNF family receptor alpha like involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16086688) Ensembl
MGI		 PMID:16086688 GO_REF:0000107 NCBI chr 6:54,878,072...54,946,716
Ensembl chr 6:56,512,880...56,581,527 		JBrowse link
G KAT7 lysine acetyltransferase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:43,875,921...43,916,352
Ensembl chr17:48,605,488...48,645,784 		JBrowse link
G MAP2K6 mitogen-activated protein kinase kinase 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:63,342,720...63,483,926
Ensembl chr17:68,730,011...68,870,454 		JBrowse link
G MAP3K20 mitogen-activated protein kinase kinase kinase 20 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:60,362,635...60,555,445
Ensembl chr2B:177,818,344...178,010,556 		JBrowse link
G MAPK11 mitogen-activated protein kinase 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:30,492,664...30,499,456
Ensembl chr22:49,492,693...49,495,732 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:35,586,847...35,683,041
Ensembl chr 6:36,788,233...36,871,114 		JBrowse link
G RHOA ras homolog family member A ISO RGD PMID:17369826 RGD:1642964 NCBI chr 3:49,282,009...49,339,887 JBrowse link
G USP25 ubiquitin specific peptidase 25 involved_in ISO (PMID:23042150) MGI PMID:23042150 NCBI chr21:2,468,993...2,618,200
Ensembl chr21:15,724,729...15,982,182 		JBrowse link
negative regulation of stress-activated MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUSP10 dual specificity phosphatase 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19696743) Ensembl
MGI		 PMID:19696743 GO_REF:0000107 NCBI chr 1:197,293,039...197,333,828
Ensembl chr 1:202,367,318...202,404,720 		JBrowse link
G FOXM1 forkhead box M1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:2,978,400...2,999,077
Ensembl chr12:2,910,028...2,930,503 		JBrowse link
G FOXO1 forkhead box O1 involved_in ISO (PMID:19696738) BHF-UCL PMID:19696738 NCBI chr13:21,763,729...21,874,279 JBrowse link
G GSTP1 glutathione S-transferase pi 1 involved_in ISO (PMID:16023107) BHF-UCL PMID:16023107 NCBI chr11:62,942,756...62,945,701
Ensembl chr11:66,253,421...66,256,472 		JBrowse link
G IGBP1 immunoglobulin binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:59,401,426...59,434,363
Ensembl chr  X:69,460,734...69,493,616 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor involved_in ISS UniProt GO_REF:0000024 NCBI chr 8:124,387,561...124,393,551
Ensembl chr 8:127,131,512...127,136,863 		JBrowse link
G PBK PDZ binding kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21715333) Ensembl
MGI		 PMID:21715333 GO_REF:0000107 NCBI chr 8:27,084,789...27,112,986
Ensembl chr 8:24,285,395...24,313,658 		JBrowse link
G PPIA peptidylprolyl isomerase A involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:45,510,450...45,515,448
Ensembl chr 7:45,578,765...45,605,545 		JBrowse link
G QARS1 glutaminyl-tRNA synthetase 1 involved_in ISO (PMID:11096076) CAFA PMID:11096076 NCBI chr 3:49,020,310...49,029,443
Ensembl chr 3:50,100,216...50,125,112 		JBrowse link
negative regulation of stress-activated protein kinase signaling cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAP3K20 mitogen-activated protein kinase kinase kinase 20 involved_in ISO (PMID:35857590) UniProt PMID:35857590 NCBI chr2B:60,362,635...60,555,445
Ensembl chr2B:177,818,344...178,010,556 		JBrowse link
positive regulation of stress-activated MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARL6IP5 ARF like GTPase 6 interacting protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:69,020,908...69,042,065
Ensembl chr 3:70,387,581...70,408,909 		JBrowse link
G CARD9 caspase recruitment domain family member 9 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:17187069) MGI
Ensembl		 PMID:17187069 GO_REF:0000107 NCBI chr 9:107,432,709...107,446,271
Ensembl chr 9:136,416,279...136,424,756 		JBrowse link
G CLEC7A C-type lectin domain containing 7A involved_in ISO (PMID:27288407) UniProt PMID:27288407 NCBI chr12:10,161,780...10,174,943
Ensembl chr12:10,410,384...10,425,452 		JBrowse link
G CRHR2 corticotropin releasing hormone receptor 2 ISO RGD PMID:19211730 RGD:5130956 NCBI chr 7:31,265,619...31,313,902
Ensembl chr 7:31,386,026...31,434,220 		JBrowse link
G EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:37,130,386...37,184,587
Ensembl chr2A:37,895,814...37,941,686 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase ISO RGD PMID:17161379 RGD:5508698 NCBI chr 5:39,936,630...39,961,519
Ensembl chr 5:40,548,919...40,573,785 		JBrowse link
G IGFBP6 insulin like growth factor binding protein 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:35,654,172...35,659,115
Ensembl chr12:36,435,221...36,440,132 		JBrowse link
G IL1A interleukin 1 alpha ISO RGD PMID:15671867 RGD:1358666 NCBI chr2A:89,273,482...89,284,421
Ensembl chr2A:113,784,854...113,795,801 		JBrowse link
G IL1B interleukin 1 beta ISO RGD PMID:12629164 PMID:15671867 RGD:1358666 RGD:1626685 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G IL26 interleukin 26 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:65,710,066...65,734,659
Ensembl chr12:68,495,807...68,519,637 		JBrowse link
G INAVA innate immunity activator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:176,491,264...176,514,719
Ensembl chr 1:180,794,646...180,818,853 		JBrowse link
G KISS1 KiSS-1 metastasis suppressor NOT ISO RGD PMID:16222076 RGD:1599289
G KLHDC10 kelch domain containing 10 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 7:122,036,564...122,101,840
Ensembl chr 7:134,555,062...134,620,225 		JBrowse link
G MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 ISO RGD PMID:12024021 RGD:2302280 NCBI chr22:30,846,613...30,857,737
Ensembl chr22:49,957,769...49,966,986 		JBrowse link
G MID1 midline 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:3,075,834...3,463,845
Ensembl chr  X:10,328,476...10,459,284 		JBrowse link
G NOD1 nucleotide binding oligomerization domain containing 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18261938) Ensembl
MGI		 PMID:18261938 GO_REF:0000107 NCBI chr 7:31,060,245...31,109,012
Ensembl chr 7:31,182,275...31,208,742 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:17187069)
(PMID:18261938)		 MGI
Ensembl		 PMID:17187069 PMID:18261938 GO_REF:0000107 NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773 		JBrowse link
G PDCD10 programmed cell death 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:164,703,909...164,755,085
Ensembl chr 3:172,760,923...172,811,430 		JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11894098), (PMID:18261938)
(PMID:11894097)		 Ensembl
MGI		 PMID:11894097 PMID:11894098 PMID:18261938 GO_REF:0000107 NCBI chr 8:86,447,216...86,480,511
Ensembl chr 8:88,398,468...88,456,268 		JBrowse link
G SCIMP SLP adaptor and CSK interacting membrane protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:5,258,376...5,283,747
Ensembl chr17:5,247,307...5,270,817 		JBrowse link
G SEMA4C semaphorin 4C involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:102,443,333...102,455,176
Ensembl chr2A:97,780,242...97,787,341 		JBrowse link
G STK25 serine/threonine kinase 25 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:128,766,408...128,779,939
Ensembl chr2B:247,560,624...247,574,249 		JBrowse link
G TAOK1 TAO kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:27,222,725...27,385,713
Ensembl chr17:27,746,797...27,840,623 		JBrowse link
G TAOK2 TAO kinase 2 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:30,347,229...30,366,743 JBrowse link
G TAOK3 TAO kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:115,730,619...115,954,149
Ensembl chr12:119,109,642...119,226,502 		JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:193,907,398...194,005,800
Ensembl chr 1:198,758,751...198,859,041 		JBrowse link
G TLR4 toll like receptor 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18261938) Ensembl
MGI		 PMID:18261938 GO_REF:0000107 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
regulation of stress-activated MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FAS Fas cell surface death receptor involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612 		JBrowse link
G GREM1 gremlin 1, DAN family BMP antagonist NOT|involved_in ISO (PMID:12135612) BHF-UCL PMID:12135612 NCBI chr15:11,213,870...11,230,619 JBrowse link
G GSTP1 glutathione S-transferase pi 1 involved_in ISO (PMID:10945608) BHF-UCL PMID:10945608 NCBI chr11:62,942,756...62,945,701
Ensembl chr11:66,253,421...66,256,472 		JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 involved_in IEA UniProt GO_REF:0000117 NCBI chr15:45,337,117...45,438,826
Ensembl chr15:63,613,961...63,714,161 		JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 involved_in IEA UniProt GO_REF:0000117 NCBI chr19:3,114,445...3,148,619
Ensembl chr19:4,064,626...4,097,933 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 involved_in IEA UniProt GO_REF:0000117 NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 involved_in IEA UniProt GO_REF:0000117 Ensembl chr16:30,489,362...30,498,017 JBrowse link
G NBR1 NBR1 autophagy cargo receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:14,119,638...14,197,827
Ensembl chr17:14,351,229...14,390,597 		JBrowse link
G PRDX1 peroxiredoxin 1 acts_upstream_of_or_within ISO (PMID:16880205) MGI PMID:16880205 NCBI chr 1:44,813,508...44,824,430
Ensembl chr 1:46,171,453...46,182,018 		JBrowse link
regulation of stress-activated protein kinase signaling cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ZMPSTE24 zinc metallopeptidase STE24 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16079796) Ensembl
MGI		 PMID:16079796 GO_REF:0000107 NCBI chr 1:39,545,264...39,589,721
Ensembl chr 1:40,869,076...40,912,747 		JBrowse link
stress-activated MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:21367774 RGD:5129174 NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044 		JBrowse link
G CARD9 caspase recruitment domain family member 9 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:17187069) Ensembl
MGI		 PMID:17187069 GO_REF:0000107 NCBI chr 9:107,432,709...107,446,271
Ensembl chr 9:136,416,279...136,424,756 		JBrowse link
G CD2AP CD2 associated protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15213232) Ensembl
MGI		 PMID:15213232 GO_REF:0000107 NCBI chr 6:47,065,284...47,210,746
Ensembl chr 6:48,328,863...48,474,163 		JBrowse link
G CRYAB crystallin alpha B ISO RGD PMID:18420382 RGD:2303631 NCBI chr11:106,795,406...106,800,019
Ensembl chr11:110,639,442...110,644,272 		JBrowse link
G DUSP10 dual specificity phosphatase 10 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:19696743) Ensembl
MGI		 PMID:19696743 GO_REF:0000107 NCBI chr 1:197,293,039...197,333,828
Ensembl chr 1:202,367,318...202,404,720 		JBrowse link
G MAP2K6 mitogen-activated protein kinase kinase 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:63,342,720...63,483,926
Ensembl chr17:68,730,011...68,870,454 		JBrowse link
G MAP2K7 mitogen-activated protein kinase kinase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:7,205,124...7,215,776
Ensembl chr19:8,057,598...8,066,512 		JBrowse link
G MAP3K13 mitogen-activated protein kinase kinase kinase 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:182,319,405...182,517,655
Ensembl chr 3:190,798,694...190,993,633 		JBrowse link
G MAP3K20 mitogen-activated protein kinase kinase kinase 20 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:60,362,635...60,555,445
Ensembl chr2B:177,818,344...178,010,556 		JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:134,316,841...134,582,843
Ensembl chr 6:138,406,398...138,641,727 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:88,398,329...88,470,926
Ensembl chr 6:91,664,263...91,737,468 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335 		JBrowse link
G MAPK11 mitogen-activated protein kinase 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:30,492,664...30,499,456
Ensembl chr22:49,492,693...49,495,732 		JBrowse link
G MAPK13 mitogen-activated protein kinase 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:35,689,475...35,711,990
Ensembl chr 6:36,890,974...36,899,388 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 involved_in ISO
IEA		 RGD
Ensembl		 PMID:16407200 GO_REF:0000107 RGD:1580544 NCBI chr 6:35,586,847...35,683,041
Ensembl chr 6:36,788,233...36,871,114 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:30,489,362...30,498,017 JBrowse link
G MAPK8 mitogen-activated protein kinase 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:45,806,748...45,936,362 JBrowse link
G NOD1 nucleotide binding oligomerization domain containing 1 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:18261938) Ensembl
MGI		 PMID:18261938 GO_REF:0000107 NCBI chr 7:31,060,245...31,109,012
Ensembl chr 7:31,182,275...31,208,742 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:18261938) Ensembl
MGI		 PMID:18261938 GO_REF:0000107 NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773 		JBrowse link
G PBK PDZ binding kinase involved_in
acts_upstream_of		 IEA
ISO		 (PMID:21715333) Ensembl
MGI		 PMID:21715333 GO_REF:0000107 NCBI chr 8:27,084,789...27,112,986
Ensembl chr 8:24,285,395...24,313,658 		JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:11894098), (PMID:18261938)
(PMID:11894097)		 Ensembl
MGI		 PMID:11894097 PMID:11894098 PMID:18261938 GO_REF:0000107 NCBI chr 8:86,447,216...86,480,511
Ensembl chr 8:88,398,468...88,456,268 		JBrowse link
G TAOK2 TAO kinase 2 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:30,347,229...30,366,743 JBrowse link
G TLR4 toll like receptor 4 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:18261938) Ensembl
MGI		 PMID:18261938 GO_REF:0000107 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16641
    cellular process 16198
      cellular response to stimulus 6991
        cellular response to stress 1912
          stress-activated protein kinase signaling cascade 63
            negative regulation of stress-activated protein kinase signaling cascade + 10
            positive regulation of stress-activated protein kinase signaling cascade + 27
            regulation of stress-activated protein kinase signaling cascade + 46
            stress-activated MAPK cascade + 57
Path 2
Term Annotations click to browse term
  biological_process 16641
    biological regulation 11630
      regulation of biological process 11253
        regulation of cellular process 10896
          signal transduction 5469
            intracellular signal transduction 2885
              stress-activated protein kinase signaling cascade 63
                negative regulation of stress-activated protein kinase signaling cascade + 10
                positive regulation of stress-activated protein kinase signaling cascade + 27
                regulation of stress-activated protein kinase signaling cascade + 46
                stress-activated MAPK cascade + 57
paths to the root