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ONTOLOGY REPORT - ANNOTATIONS

Term:response to sterol depletion
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Accession:GO:0006991 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
Synonyms:exact_synonym: sterol depletion response


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response to sterol depletion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insig1 insulin induced gene 1 acts_upstream_of_or_within ISO (PMID:12242332) RGD PMID:12242332 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Insig2 insulin induced gene 2 acts_upstream_of_or_within ISO (PMID:12354157) RGD PMID:12354157 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase IEP RGD PMID:10330413 RGD:2303706 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Pip4p1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:25035345), (PMID:29146937)		 UniProt
RGD		 PMID:25035345 PMID:29146937 GO_REF:0000024 NCBI chr15:24,146,854...24,150,739
Ensembl chr15:24,146,856...24,150,702 		JBrowse link
cellular response to sterol depletion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 involved_in ISO (PMID:19325169) RGD PMID:19325169 NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113 		JBrowse link
positive regulation of SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir96 microRNA 96 involved_in ISO (PMID:30460077) RGD PMID:30460077 NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516 		JBrowse link
G Spring1 SREBF pathway regulator in golgi 1 involved_in ISO (PMID:32111832)
(MGI:6401656|PMID:32111832)		 RGD PMID:32111832 MGI:6401656 NCBI chr12:38,306,227...38,329,175
Ensembl chr12:38,297,837...38,329,138 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO (MGI:6120228|PMID:29420538) RGD PMID:29420538 MGI:6120228 NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236 		JBrowse link
regulation of SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amfr autocrine motility factor receptor involved_in ISO (MGI:6276494|PMID:22863805) RGD PMID:22863805 MGI:6276494 NCBI chr19:10,996,705...11,032,260
Ensembl chr19:10,996,099...11,032,247 		JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:4456438 (PMID:28797121)		 Ensembl
RGD		 PMID:28797121 GO_REF:0000107 NCBI chr12:32,052,542...32,061,628
Ensembl chr12:32,052,543...32,071,903 		JBrowse link
SREBP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef10l Rho guanine nucleotide exchange factor 10 like involved_in ISO
IBA		 (PMID:16112081)
GO_REF:0000033		 RGD
GO_Central		 PMID:16112081 GO_REF:0000033 NCBI chr 5:152,792,247...152,935,255
Ensembl chr 5:152,792,252...152,919,538 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A acts_upstream_of_or_within ISO (PMID:18852460) RGD PMID:18852460 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within ISO (PMID:18852460) RGD PMID:18852460 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in ISO
IBA		 (PMID:24217618)
GO_REF:0000033		 RGD
GO_Central		 PMID:24217618 GO_REF:0000033 NCBI chr 1:242,921,147...242,956,472
Ensembl chr 1:242,921,152...242,956,394 		JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in ISO
IBA		 (PMID:24217618)
GO_REF:0000033		 RGD
GO_Central		 PMID:24217618 GO_REF:0000033 NCBI chr16:65,017,654...65,034,184
Ensembl chr16:65,018,532...65,033,671 		JBrowse link
G Insig1 insulin induced gene 1 involved_in ISO
IBA		 (PMID:12242332), (PMID:32322062)
GO_REF:0000033		 RGD
GO_Central		 PMID:12242332 PMID:32322062 GO_REF:0000033 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Insig2 insulin induced gene 2 involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
(PMID:12242332), (PMID:17428920), (PMID:32322062)		 UniProt
GO_Central
Ensembl
RGD		 PMID:12242332 PMID:17428920 PMID:32322062 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923 		JBrowse link
G LOC120102490 insulin-induced gene 1 protein-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:67,330,399...67,331,371
Ensembl chr 4:67,330,588...67,331,346 		JBrowse link
G Scap SREBF chaperone involved_in ISO
ISS		 (PMID:11726962), (PMID:32322062)
GO_REF:0000024		 RGD
UniProt		 PMID:11726962 PMID:32322062 GO_REF:0000024 NCBI chr 8:110,306,026...110,360,677
Ensembl chr 8:110,306,031...110,360,666 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 involved_in ISO
ISS		 (PMID:27614840)
GO_REF:0000024
(PMID:32322062)		 RGD
UniProt		 PMID:27614840 PMID:32322062 GO_REF:0000024 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:32322062)
(PMID:27614840)		 Ensembl
UniProt
RGD		 PMID:27614840 PMID:32322062 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
SREBP-SCAP complex retention in endoplasmic reticulum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insig1 insulin induced gene 1 involved_in ISO
IBA		 (PMID:12202038), (PMID:15899885), (PMID:32322062)
GO_REF:0000033		 RGD
GO_Central		 PMID:12202038 PMID:15899885 PMID:32322062 GO_REF:0000033 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Insig2 insulin induced gene 2 involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
(PMID:15899885), (PMID:32322062)		 UniProt
GO_Central
Ensembl
RGD		 PMID:15899885 PMID:32322062 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923 		JBrowse link
G LOC120102490 insulin-induced gene 1 protein-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:67,330,399...67,331,371
Ensembl chr 4:67,330,588...67,331,346 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    response to stimulus 10515
      response to stress 4181
        response to sterol depletion 19
          cellular response to sterol depletion + 17
paths to the root