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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA damage checkpoint signaling
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Accession:GO:0000077 term browser browse the term
Definition:A signal transduction process that contributes to a DNA damage checkpoint.
Synonyms:exact_synonym: DNA damage checkpoint;   signal transduction involved in DNA damage checkpoint
 narrow_synonym: DNA damage response, signal transduction resulting in cell cycle arrest
 alt_id: GO:0072422
 xref: Wikipedia:DNA_damage_checkpoint;   Wikipedia:Postreplication_checkpoint

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DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12937170) MGI
Ensembl		 PMID:12937170 GO_REF:0000107 NCBI chr 1:99,653,208...99,786,889
Ensembl chr 1:99,653,139...99,791,520 		JBrowse link
G ATR ATR serine/threonine kinase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12937170) MGI
TreeGrafter
Ensembl		 PMID:12937170 GO_REF:0000107 GO_REF:0000118 NCBI chr15:48,048,785...48,173,120
Ensembl chr15:48,048,882...48,173,137 		JBrowse link
G ATRIP ATR interacting protein involved_in IEA InterPro GO_REF:0000002 NCBI chr22:9,849,439...9,869,654
Ensembl chr22:9,849,570...9,869,553 		JBrowse link
G CDC5L cell division cycle 5 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:27,727,185...27,785,233
Ensembl chr17:27,722,819...27,785,268 		JBrowse link
G CHEK1 checkpoint kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10859164)
(PMID:12529385)		 InterPro
MGI		 PMID:10859164 PMID:12529385 GO_REF:0000002 NCBI chr 1:116,768,141...116,809,557
Ensembl chr 1:116,767,944...116,801,371 		JBrowse link
G CHEK2 checkpoint kinase 2 ISO RGD PMID:10435585 RGD:633752 NCBI chr19:11,567,529...11,621,180
Ensembl chr19:11,567,528...11,604,792 		JBrowse link
G CLOCK clock circadian regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:13,015,198...13,134,741
Ensembl chr 7:13,051,454...13,127,240 		JBrowse link
G CLSPN claspin involved_in ISO (PMID:16963448) UniProt PMID:16963448 NCBI chr20:97,096,529...97,132,305 JBrowse link
G DONSON DNA replication fork stabilization factor DONSON involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:58,598,341...58,627,279
Ensembl chr 2:58,598,967...58,609,316 		JBrowse link
G DOT1L DOT1 like histone lysine methyltransferase involved_in IEA UniProt
TreeGrafter		 GO_REF:0000104 GO_REF:0000118 NCBI chr 6:1,962,077...2,030,732
Ensembl chr 6:1,962,279...2,026,455 		JBrowse link
G DTX3L deltex E3 ubiquitin ligase 3L involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:58,287,331...58,298,519
Ensembl chr22:58,290,764...58,298,376 		JBrowse link
G E2F1 E2F transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:37,968,541...37,980,461
Ensembl chr 2:37,968,556...37,980,326 		JBrowse link
G EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in IEA InterPro GO_REF:0000002 NCBI chr26:42,966,095...43,072,083
Ensembl chr26:42,962,447...43,072,001 		JBrowse link
G GNB1L G protein subunit beta 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:5,889,395...5,959,515
Ensembl chr19:5,890,567...5,959,510 		JBrowse link
G H2AFX histone H2AX NOT|acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11934988) MGI
Ensembl		 PMID:11934988 GO_REF:0000107 NCBI chr 1:110,466,692...110,468,776
Ensembl chr 1:110,467,775...110,468,206 		JBrowse link
G HINFP histone H4 transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:110,495,188...110,509,855
Ensembl chr 1:110,500,566...110,510,222 		JBrowse link
G HUS1 HUS1 checkpoint clamp component involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12529385) Ensembl
MGI
InterPro		 PMID:12529385 GO_REF:0000002 GO_REF:0000107 NCBI chr21:10,826,799...10,841,579
Ensembl chr21:10,826,846...10,841,382 		JBrowse link
G INTS7 integrator complex subunit 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:17,485,353...17,573,178
Ensembl chr25:17,485,316...17,574,144 		JBrowse link
G LOC103215829 DNA excision repair protein ERCC-6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:42,288,702...42,370,045
Ensembl chr 9:42,288,825...42,373,906 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:51,919,656...52,057,376
Ensembl chr 8:51,919,808...52,057,959 		JBrowse link
G MAP3K20 mitogen-activated protein kinase kinase kinase 20 involved_in ISO (PMID:11836244) UniProt PMID:11836244 NCBI chr10:58,573,303...58,764,759 JBrowse link
G MAPK14 mitogen-activated protein kinase 14 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12937170) Ensembl
MGI		 PMID:12937170 GO_REF:0000107 NCBI chr17:36,012,164...36,095,542
Ensembl chr17:36,014,454...36,095,138 		JBrowse link
G NBN nibrin acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12529385) MGI
Ensembl		 PMID:12529385 GO_REF:0000107 NCBI chr 8:85,017,807...85,069,219
Ensembl chr 8:85,015,752...85,069,028 		JBrowse link
G PARP9 poly(ADP-ribose) polymerase family member 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:58,297,526...58,336,243
Ensembl chr22:58,298,046...58,337,124 		JBrowse link
G PRPF19 pre-mRNA processing factor 19 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:12,942,238...12,958,853
Ensembl chr 1:12,942,213...12,959,947 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12937170) Ensembl
MGI		 PMID:12937170 GO_REF:0000107 NCBI chr11:107,658,495...107,754,457
Ensembl chr11:107,658,453...107,752,637 		JBrowse link
G RAD1 RAD1 checkpoint DNA exonuclease involved_in IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:33,800,279...33,807,986
Ensembl chr 4:33,801,230...33,807,457 		JBrowse link
G RAD17 RAD17 checkpoint clamp loader component involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 4:65,456,174...65,501,665
Ensembl chr 4:65,457,763...65,501,157 		JBrowse link
G RAD9A RAD9 checkpoint clamp component A involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 1:6,865,990...6,945,179
Ensembl chr 1:6,866,840...6,941,486 		JBrowse link
G RAD9B RAD9 checkpoint clamp component B involved_in IEA InterPro GO_REF:0000002 NCBI chr11:105,738,247...105,772,539
Ensembl chr11:105,738,867...105,772,002 		JBrowse link
G RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 involved_in IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr11:2,941,055...2,955,421
Ensembl chr11:2,941,001...2,955,438 		JBrowse link
G RPA4 replication protein A4 involved_in ISO (PMID:19942684) UniProt PMID:19942684 NCBI chr  X:85,323,910...85,325,997 JBrowse link
G SMG1 SMG1 nonsense mediated mRNA decay associated PI3K related kinase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:17,103,482...17,217,554
Ensembl chr 5:17,116,231...17,217,488 		JBrowse link
G STK38 serine/threonine kinase 38 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:35,587,246...35,641,555
Ensembl chr17:35,587,256...35,642,279 		JBrowse link
G TIPIN TIMELESS interacting protein acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:17141802) MGI
Ensembl		 PMID:17141802 GO_REF:0000107 NCBI chr26:17,194,859...17,214,671
Ensembl chr26:17,198,734...17,214,810 		JBrowse link
G TIPRL TOR signaling pathway regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:60,842,563...60,869,380
Ensembl chr25:60,841,783...60,869,258 		JBrowse link
G TOPBP1 DNA topoisomerase II binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:56,679,333...56,740,773
Ensembl chr15:56,679,426...56,741,566 		JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr26:39,489,925...39,595,096
Ensembl chr26:39,508,600...39,594,927 		JBrowse link
G TREX1 three prime repair exonuclease 1 acts_upstream_of_or_within ISO (PMID:18045533) MGI PMID:18045533 NCBI chr22:9,869,502...9,871,659 JBrowse link
G UFL1 UFM1 specific ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:77,357,239...77,387,385
Ensembl chr13:77,357,141...77,387,367 		JBrowse link
G USP28 ubiquitin specific peptidase 28 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:105,175,116...105,257,163
Ensembl chr 1:105,175,067...105,257,102 		JBrowse link
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP2 caspase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:112,172,614...112,189,574
Ensembl chr21:112,172,733...112,188,744 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:35,445,668...35,454,334
Ensembl chr17:35,445,223...35,454,342 		JBrowse link
G CRADD CASP2 and RIPK1 domain containing adaptor with death domain involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:89,066,952...89,246,177 JBrowse link
G E2F7 E2F transcription factor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:72,598,220...72,642,366
Ensembl chr11:72,599,353...72,641,420 		JBrowse link
G MDM2 MDM2 proto-oncogene involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:64,434,203...64,465,490
Ensembl chr11:64,434,261...64,469,890 		JBrowse link
G MUC1 mucin 1, cell surface associated involved_in ISO (PMID:15710329) BHF-UCL PMID:15710329 NCBI chr20:8,641,701...8,646,739
Ensembl chr20:8,642,842...8,646,962 		JBrowse link
G PCBP4 poly(rC) binding protein 4 involved_in ISO (PMID:10891498) UniProt PMID:10891498 NCBI chr22:13,326,069...13,336,474
Ensembl chr22:13,325,551...13,329,903 		JBrowse link
G PIDD1 p53-induced death domain protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:602,594...609,388
Ensembl chr 1:602,721...607,893 		JBrowse link
G PML PML nuclear body scaffold involved_in ISO (PMID:15626733) UniProt PMID:15626733 NCBI chr26:9,441,998...9,494,949
Ensembl chr26:9,451,112...9,494,931 		JBrowse link
G PPP2R5C protein phosphatase 2 regulatory subunit B'gamma involved_in ISO (PMID:17245430) UniProt PMID:17245430 NCBI chr24:79,703,316...79,875,379
Ensembl chr24:79,703,312...79,875,389 		JBrowse link
G PRAP1 proline rich acidic protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:53,195,600...53,201,846 JBrowse link
G RBM38 RNA binding motif protein 38 involved_in ISO (PMID:17050675) UniProt PMID:17050675 NCBI chr 2:6,709,975...6,727,534
Ensembl chr 2:6,711,458...6,727,353 		JBrowse link
G RPL26 ribosomal protein L26 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:7,733,652...7,740,384
Ensembl chr16:7,732,921...7,740,325 		JBrowse link
G TP53 tumor protein p53 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16107883) Ensembl
MGI		 PMID:16107883 GO_REF:0000107 NCBI chr16:7,047,686...7,065,567
Ensembl chr16:7,045,146...7,066,223 		JBrowse link
mitotic DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC7 cell division cycle 7 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:41,714,250...41,739,159
Ensembl chr20:41,715,572...41,739,138 		JBrowse link
G CHEK2 checkpoint kinase 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:11,567,529...11,621,180
Ensembl chr19:11,567,528...11,604,792 		JBrowse link
G LOC103226086 cell division cycle 7-related protein kinase-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr21:9,494,995...9,496,895 JBrowse link
G ZNF830 zinc finger protein 830 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23213458) MGI
Ensembl
TreeGrafter		 PMID:23213458 GO_REF:0000107 GO_REF:0000118 NCBI chr16:28,468,548...28,470,150
Ensembl chr16:28,468,616...28,469,734 		JBrowse link
mitotic G1 DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCND1 cyclin D1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:4,909,616...4,922,272
Ensembl chr 1:4,907,353...4,922,357 		JBrowse link
G DGKZ diacylglycerol kinase zeta involved_in ISO (PMID:16286473) UniProt PMID:16286473 NCBI chr 1:18,949,360...18,997,957
Ensembl chr 1:18,948,425...18,982,354 		JBrowse link
G FBXO31 F-box protein 31 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:72,696,868...72,752,480
Ensembl chr 5:72,701,136...72,752,989 		JBrowse link
G GIGYF2 GRB10 interacting GYF protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19744960) Ensembl
MGI		 PMID:19744960 GO_REF:0000107 NCBI chr10:118,720,668...118,883,299
Ensembl chr10:118,720,690...118,874,162 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:43,915,226...44,119,547
Ensembl chr 8:43,914,636...44,119,541 		JBrowse link
G RFWD3 ring finger and WD repeat domain 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:53,045,408...53,092,214
Ensembl chr 5:53,045,465...53,092,494 		JBrowse link
G RPA2 replication protein A2 involved_in ISO (PMID:21731742) UniProt PMID:21731742 NCBI chr20:104,882,739...104,904,612 JBrowse link
G RPA2 replication protein A2 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr20:104,883,027...104,904,951 JBrowse link
G RPS27L ribosomal protein S27 like involved_in ISO (PMID:18056458) UniProt PMID:18056458 NCBI chr26:20,385,684...20,389,351 JBrowse link
G SDE2 SDE2 telomere maintenance homolog involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:3,779,561...3,793,496
Ensembl chr25:3,779,560...3,795,893 		JBrowse link
G TP53 tumor protein p53 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16107883) Ensembl
MGI		 PMID:16107883 GO_REF:0000107 NCBI chr16:7,047,686...7,065,567
Ensembl chr16:7,045,146...7,066,223 		JBrowse link
G TREX1 three prime repair exonuclease 1 acts_upstream_of_or_within ISO (PMID:23993650)
(PMID:18045533)		 MGI PMID:18045533 PMID:23993650 NCBI chr22:9,869,502...9,871,659 JBrowse link
G WAC WW domain containing adaptor with coiled-coil involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:28,131,774...28,222,501
Ensembl chr 9:28,131,769...28,219,134 		JBrowse link
mitotic G2 DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABRAXAS1 abraxas 1, BRCA1 A complex subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:31,852,411...31,875,968
Ensembl chr 7:31,853,490...31,875,189 		JBrowse link
G ATM ATM serine/threonine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:99,653,208...99,786,889
Ensembl chr 1:99,653,139...99,791,520 		JBrowse link
G BABAM1 BRISC and BRCA1 A complex member 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:15,775,344...15,786,715
Ensembl chr 6:15,775,229...15,786,822 		JBrowse link
G BABAM2 BRISC and BRCA1 A complex member 2 involved_in IEA Ensembl
UniProt		 GO_REF:0000104 GO_REF:0000107 NCBI chr14:79,277,238...79,732,996
Ensembl chr14:79,289,043...79,732,891 		JBrowse link
G BLM BLM RecQ like helicase involved_in IEA Ensembl GO_REF:0000107 NCBI chr29:9,046,485...9,152,320
Ensembl chr29:9,045,373...9,152,254 		JBrowse link
G BRCA1 BRCA1 DNA repair associated involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr16:63,162,827...63,243,928 JBrowse link
G BRCC3 BRCA1/BRCA2-containing complex subunit 3 involved_in IEA UniProt
Ensembl		 GO_REF:0000104 GO_REF:0000107 NCBI chr  X:129,358,759...129,406,293
Ensembl chr  X:129,358,862...129,403,352 		JBrowse link
G BRSK1 BR serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:47,888,813...47,915,019
Ensembl chr 6:47,888,920...47,917,920 		JBrowse link
G CDC14B cell division cycle 14B involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:106,520,152...106,645,468
Ensembl chr12:106,572,015...106,633,316 		JBrowse link
G CDK1 cyclin dependent kinase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12937170) MGI
TreeGrafter		 PMID:12937170 GO_REF:0000118 NCBI chr 9:70,475,736...70,492,947 JBrowse link
G CDK5RAP3 CDK5 regulatory subunit associated protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:68,367,591...68,382,000
Ensembl chr16:68,370,483...68,382,022 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:35,445,668...35,454,334
Ensembl chr17:35,445,223...35,454,342 		JBrowse link
G CHEK1 checkpoint kinase 1 involved_in ISO (PMID:20932473) UniProt PMID:20932473 NCBI chr 1:116,768,141...116,809,557
Ensembl chr 1:116,767,944...116,801,371 		JBrowse link
G CLSPN claspin involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:97,096,529...97,132,305 JBrowse link
G CREB3L1 cAMP responsive element binding protein 3 like 1 involved_in ISO (PMID:37178686) UniProt PMID:37178686 NCBI chr 1:19,009,169...19,054,841
Ensembl chr 1:19,009,035...19,054,804 		JBrowse link
G CUNH10orf90 chromosome unknown C10orf90 homolog involved_in ISO (PMID:20154723) UniProt PMID:20154723 NCBI chr 9:119,049,797...119,290,121
Ensembl chr 9:119,050,676...119,136,762 		JBrowse link
G DONSON DNA replication fork stabilization factor DONSON involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:58,598,341...58,627,279
Ensembl chr 2:58,598,967...58,609,316 		JBrowse link
G DTL denticleless E3 ubiquitin protein ligase homolog involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr25:17,418,078...17,485,320
Ensembl chr25:17,418,090...17,485,164 		JBrowse link
G FOXN3 forkhead box N3 involved_in ISO (PMID:9154802) UniProt PMID:9154802 NCBI chr24:66,832,760...67,103,637 JBrowse link
G FOXN3 forkhead box N3 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr24:66,834,410...67,103,656 JBrowse link
G FOXO4 forkhead box O4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12048180) Ensembl
MGI		 PMID:12048180 GO_REF:0000107 NCBI chr  X:60,893,711...60,901,134
Ensembl chr  X:60,893,526...60,902,844 		JBrowse link
G FZR1 fizzy and cell division cycle 20 related 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:3,272,247...3,300,370
Ensembl chr 6:3,288,407...3,298,464 		JBrowse link
G IER3 immediate early response 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20467439) Ensembl
MGI		 PMID:20467439 GO_REF:0000107 NCBI chr17:41,712,539...41,713,895
Ensembl chr17:41,712,528...41,714,126 		JBrowse link
G LOC103221857 E3 ubiquitin-protein ligase TRIM39 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:42,142,185...42,159,256
Ensembl chr17:42,142,073...42,158,764 		JBrowse link
G LOC103244593 cyclin-dependent kinase 1-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr23:40,070,145...40,071,558 JBrowse link
G LOC103244924 cyclin-G1 ISO RGD PMID:9464250 RGD:2316029 NCBI chr23:65,709,759...65,716,913
Ensembl chr23:65,709,786...65,714,711 		JBrowse link
G MBD4 methyl-CpG binding domain 4, DNA glycosylase acts_upstream_of_or_within ISO (PMID:14614141) MGI PMID:14614141 NCBI chr22:51,616,840...51,626,232
Ensembl chr22:51,616,803...51,626,224 		JBrowse link
G MBTPS1 membrane bound transcription factor peptidase, site 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:69,464,064...69,527,588
Ensembl chr 5:69,463,920...69,527,541 		JBrowse link
G MBTPS2 membrane bound transcription factor peptidase, site 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:20,319,731...20,364,603
Ensembl chr  X:20,319,807...20,361,847 		JBrowse link
G MRE11 MRE11 homolog, double strand break repair nuclease acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14690604) MGI
Ensembl
TreeGrafter		 PMID:14690604 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:85,615,448...85,694,247
Ensembl chr 1:85,610,819...85,694,269 		JBrowse link
G MRNIP MRN complex interacting protein involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr23:81,571,083...81,590,906
Ensembl chr23:81,571,199...81,590,815 		JBrowse link
G NBN nibrin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18614044) Ensembl
TreeGrafter
MGI
InterPro		 PMID:18614044 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:85,017,807...85,069,219
Ensembl chr 8:85,015,752...85,069,028 		JBrowse link
G NOP53 NOP53 ribosome biogenesis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:41,058,199...41,070,220
Ensembl chr 6:41,057,906...41,071,202 		JBrowse link
G PLK1 polo like kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:21,388,957...21,408,574
Ensembl chr 5:21,396,204...21,410,718 		JBrowse link
G RINT1 RAD50 interactor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:74,454,916...74,491,057
Ensembl chr21:74,454,947...74,490,768 		JBrowse link
G SYF2 SYF2 pre-mRNA splicing factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22448250) Ensembl
MGI		 PMID:22448250 GO_REF:0000107 NCBI chr20:107,468,855...107,478,822
Ensembl chr20:107,468,940...107,479,036 		JBrowse link
G TAOK1 TAO kinase 1 involved_in ISO (PMID:17396146) UniProt PMID:17396146 NCBI chr16:23,145,629...23,291,694 JBrowse link
G TAOK1 TAO kinase 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:23,145,809...23,282,784 JBrowse link
G TAOK2 TAO kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:26,669,687...26,688,418
Ensembl chr 5:26,669,702...26,688,389 		JBrowse link
G TAOK3 TAO kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:113,485,871...113,717,213
Ensembl chr11:113,484,330...113,704,271 		JBrowse link
G TICRR TOPBP1 interacting checkpoint and replication regulator involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr29:8,117,198...8,171,956 JBrowse link
G TOPBP1 DNA topoisomerase II binding protein 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr15:56,679,333...56,740,773
Ensembl chr15:56,679,426...56,741,566 		JBrowse link
G UIMC1 ubiquitin interaction motif containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:78,912,434...79,010,695
Ensembl chr23:78,911,234...79,010,264 		JBrowse link
mitotic intra-S DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF2 activating transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:60,644,623...60,734,465
Ensembl chr10:60,644,635...60,734,475 		JBrowse link
G CHEK2 checkpoint kinase 2 involved_in ISO (PMID:11298456) UniProt PMID:11298456 NCBI chr19:11,567,529...11,621,180
Ensembl chr19:11,567,528...11,604,792 		JBrowse link
G EME1 essential meiotic structure-specific endonuclease 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr16:42,949,059...42,957,323
Ensembl chr16:42,949,570...42,955,312 		JBrowse link
G EME2 essential meiotic structure-specific endonuclease subunit 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:1,682,232...1,685,863
Ensembl chr 5:1,682,249...1,685,260 		JBrowse link
G FANCD2 FA complementation group D2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr22:46,072,797...46,141,107
Ensembl chr22:46,072,761...46,140,713 		JBrowse link
G HUS1 HUS1 checkpoint clamp component involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr21:10,826,799...10,841,579
Ensembl chr21:10,826,846...10,841,382 		JBrowse link
G LOC103243152 crossover junction endonuclease MUS81 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr16:53,418,865...53,421,128 JBrowse link
G MRE11 MRE11 homolog, double strand break repair nuclease acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14690604), (PMID:18614044) MGI
TreeGrafter
Ensembl		 PMID:14690604 PMID:18614044 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:85,615,448...85,694,247
Ensembl chr 1:85,610,819...85,694,269 		JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15533840) Ensembl
MGI		 PMID:15533840 GO_REF:0000107 NCBI chr14:59,730,101...59,802,857
Ensembl chr14:59,729,789...59,802,819 		JBrowse link
G MUS81 MUS81 structure-specific endonuclease subunit involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:8,410,571...8,411,793 JBrowse link
G NEK11 NIMA related kinase 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:58,884,879...59,178,575
Ensembl chr15:58,884,771...59,175,470 		JBrowse link
G RAD17 RAD17 checkpoint clamp loader component involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:65,456,174...65,501,665
Ensembl chr 4:65,457,763...65,501,157 		JBrowse link
G RAD9A RAD9 checkpoint clamp component A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9766521) Ensembl
TreeGrafter
MGI		 PMID:9766521 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:6,865,990...6,945,179
Ensembl chr 1:6,866,840...6,941,486 		JBrowse link
G RAD9B RAD9 checkpoint clamp component B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:105,738,247...105,772,539
Ensembl chr11:105,738,867...105,772,002 		JBrowse link
G TIPIN TIMELESS interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:17,194,859...17,214,671
Ensembl chr26:17,198,734...17,214,810 		JBrowse link
G XPC XPC complex subunit, DNA damage recognition and repair factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15533840) Ensembl
MGI		 PMID:15533840 GO_REF:0000107 NCBI chr22:50,088,019...50,121,584
Ensembl chr22:50,085,353...50,121,542 		JBrowse link
negative regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRD4 bromodomain containing 4 involved_in ISO (PMID:23728299) UniProt PMID:23728299 NCBI chr 6:13,836,332...13,883,459
Ensembl chr 6:13,836,324...13,873,877 		JBrowse link
G CHEK2 checkpoint kinase 2 ISO RGD PMID:20637979 RGD:10401658 NCBI chr19:11,567,529...11,621,180
Ensembl chr19:11,567,528...11,604,792 		JBrowse link
negative regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPP1R10 protein phosphatase 1 regulatory subunit 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:41,839,504...41,857,228
Ensembl chr17:41,839,833...41,858,470 		JBrowse link
positive regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCAR2 cell cycle and apoptosis regulator 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:20,685,482...20,700,424
Ensembl chr 8:20,686,504...20,699,707 		JBrowse link
G TTI1 TELO2 interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:25,717,089...25,768,128
Ensembl chr 2:25,717,118...25,768,610 		JBrowse link
positive regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAP3K20 mitogen-activated protein kinase kinase kinase 20 involved_in ISO (PMID:15342622) UniProt PMID:15342622 NCBI chr10:58,573,303...58,764,759 JBrowse link
regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRY1 cryptochrome circadian regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:102,200,822...102,306,165
Ensembl chr11:102,204,224...102,306,182 		JBrowse link
G CUL4A cullin 4A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19481525) Ensembl
MGI		 PMID:19481525 GO_REF:0000107 NCBI chr 3:91,211,238...91,267,236
Ensembl chr 3:91,212,193...91,268,838 		JBrowse link
G ETAA1 ETAA1 activator of ATR kinase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr14:39,658,974...39,673,093
Ensembl chr14:39,659,873...39,673,259 		JBrowse link
G FBXO4 F-box protein 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21911473) Ensembl
MGI		 PMID:21911473 GO_REF:0000107 NCBI chr 4:40,682,063...40,698,364
Ensembl chr 4:40,682,333...40,698,370 		JBrowse link
G FEM1B fem-1 homolog B involved_in ISO (PMID:19330022) UniProt PMID:19330022 NCBI chr26:15,183,965...15,201,394 JBrowse link
G NEK1 NIMA related kinase 1 involved_in ISO (PMID:18843199) CACAO PMID:18843199 NCBI chr 7:115,621,917...115,819,349
Ensembl chr 7:115,621,916...115,819,291 		JBrowse link
G RFWD3 ring finger and WD repeat domain 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:53,045,408...53,092,214
Ensembl chr 5:53,045,465...53,092,494 		JBrowse link
G RNASEH2B ribonuclease H2 subunit B acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:22802351) MGI
Ensembl		 PMID:22802351 GO_REF:0000107 NCBI chr 3:28,791,490...28,856,542
Ensembl chr 3:28,791,748...28,841,733 		JBrowse link
G RPA2 replication protein A2 involved_in ISO (PMID:21504906) UniProt PMID:21504906 NCBI chr20:104,882,739...104,904,612 JBrowse link
G RPA2 replication protein A2 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr20:104,883,027...104,904,951 JBrowse link
G WDR76 WD repeat domain 76 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr26:39,178,407...39,222,005
Ensembl chr26:39,176,535...39,223,993 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17022
    cellular process 16536
      signal transduction 5609
        intracellular signal transduction 2997
          signal transduction in response to DNA damage 188
            DNA damage checkpoint signaling 126
              mitotic DNA damage checkpoint signaling + 88
              negative regulation of DNA damage checkpoint + 3
              positive regulation of DNA damage checkpoint + 3
              regulation of DNA damage checkpoint + 17
Path 2
Term Annotations click to browse term
  biological_process 17022
    biological regulation 11823
      regulation of biological process 11434
        negative regulation of biological process 5660
          negative regulation of cellular process 5413
            negative regulation of cell cycle 382
              negative regulation of cell cycle process 304
                negative regulation of cell cycle phase transition 252
                  cell cycle checkpoint signaling 187
                    DNA integrity checkpoint signaling 134
                      DNA damage checkpoint signaling 126
                        mitotic DNA damage checkpoint signaling + 88
                        negative regulation of DNA damage checkpoint + 3
                        positive regulation of DNA damage checkpoint + 3
                        regulation of DNA damage checkpoint + 17
paths to the root