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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Postoperative Cognitive Dysfunction
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Accession:DOID:9006358 term browser browse the term
Definition:A short-term decline in cognitive function (especially in memory and thinking) that may last from a few days to a few weeks after major surgery.
Synonyms:exact_synonym: Agitated Emergence;   Agitations, Emergence;   Anesthesia Emergence Delirium;   Emergence Agitation;   Emergence Delirium;   Emergence Excitement;   POCD;   Post-Operative Delirium;   Postanesthetic Excitement;   post-operative delirium;   postoperative confusion;   postoperative delirium
 primary_id: MESH:D000071257
 alt_id: DOID:9000228
 xref: EFO:0009954


show annotations for term's descendants           Sort by:
Postoperative Cognitive Dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a IEP RGD PMID:24814703 RGD:10047100 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b IEP RGD PMID:24814703 RGD:10047100 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232 		JBrowse link
G Bdnf brain-derived neurotrophic factor treatment IEP
ISO		 associated with brain ischemia RGD PMID:29571823 PMID:34964700 PMID:29599834 PMID:33324197 RGD:401959211, RGD:401965400, RGD:401976548, RGD:405850212 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment IDA
ISO		 protein:decreased phosphorylation:hippocampus RGD PMID:29571823 PMID:36688960 PMID:37736695 RGD:401959211, RGD:401959611, RGD:401960090 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Gdnf glial cell derived neurotrophic factor treatment IEP
IDA
ISO		 protein:decreased expression:hippocampus,urine
associated with rheumatic heart disease;protein:increased expression:serum
protein:altered expression:hippocampus, urine		 RGD PMID:36688960 PMID:25251457 PMID:33324197 PMID:28918204 PMID:29512789 More... RGD:401959611, RGD:405849389, RGD:405850212, RGD:405850250, RGD:405850251, RGD:405866364 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 ISO protein:increased expression:plasma (human) RGD PMID:25543030 RGD:401960875 NCBI chr14:30,737,414...30,797,317
Ensembl chr14:30,737,164...30,797,314 		JBrowse link
G Il1b interleukin 1 beta treatment IDA
IEP		 protein:increased expression:hippocampus (rat) RGD PMID:22959208 PMID:29571823 PMID:33390808 RGD:7204702, RGD:401959211, RGD:401965467 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO human protein in a rat model RGD PMID:23077050 RGD:8551854 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il6 interleukin 6 IEP protein:increased expression:hippocampus (rat) RGD PMID:33390808 RGD:401965467 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ireb2 iron responsive element binding protein 2 IEP protein:increased expression:hippocampus (rat) RGD PMID:23229539 RGD:12904023 NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 treatment IDA
ISO		 protein:decreased phosphorylation:hippocampus RGD PMID:36688960 PMID:37736695 RGD:401959611, RGD:401960090 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 treatment IDA
ISO		 protein:decreased phosphorylation:hippocampus RGD PMID:36688960 PMID:37736695 RGD:401959611, RGD:401960090 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Ngf nerve growth factor treatment ISO
IEP		 associated with brain ischemia RGD PMID:30481505 PMID:30481505 PMID:34964700 PMID:29599834 RGD:401965395, RGD:401965395, RGD:401965400, RGD:401976548 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 treatment IDA
IEP		 associated with Traumatic Brain Injuries;mRNA:decreased expression:hippocampus, hypothalamus RGD PMID:28086911 PMID:36637480 RGD:408345237, RGD:408364984 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 IEP
IMP		 protein:increased expression:hippocampus (rat) RGD PMID:33390808 PMID:33390808 RGD:401965467, RGD:401965467 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Tnf tumor necrosis factor treatment IEP protein:increased expression:hippocampus (rat) RGD PMID:29571823 PMID:33390808 RGD:401959211, RGD:401965467 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19099
    Pathological Conditions, Signs and Symptoms 13604
      Pathologic Processes 8255
        Postoperative Complications 853
          Postoperative Cognitive Dysfunction 16
Path 2
Term Annotations click to browse term
  disease 19099
    disease of anatomical entity 18440
      nervous system disease 14333
        central nervous system disease 12605
          brain disease 11834
            disease of mental health 8427
              cognitive disorder 2318
                psychotic disorder 1210
                  substance-induced psychosis 125
                    subacute delirium 18
                      Postoperative Cognitive Dysfunction 16
paths to the root