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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyclohexenecarboxylic acid
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Accession:CHEBI:23483 term browser browse the term
Synonyms:related_synonym: cyclohexenecarboxylic acids



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oseltamivir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Oseltamivir binds to and results in decreased activity of AR protein; Oseltamivir binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Ces1d carboxylesterase 1D affects hydrolysis ISO CES1 protein affects the hydrolysis of Oseltamivir CTD PMID:18983829 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Il6 interleukin 6 decreases response to substance ISO IL6 protein results in decreased susceptibility to Oseltamivir CTD PMID:17537833 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Oseltamivir binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Oseltamivir results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
perillic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rhoa ras homolog family member A multiple interactions
increases expression
ISO Mevalonic Acid affects the reaction [perillic acid results in increased expression of RHOA protein] CTD PMID:12671036 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rhob ras homolog family member B multiple interactions
increases expression
ISO Mevalonic Acid affects the reaction [perillic acid results in increased expression of RHOB protein] CTD PMID:12671036 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
JBrowse link
shikimic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd1 cyclin D1 multiple interactions
increases expression
ISO MIR300 mRNA affects the reaction [Shikimic Acid results in increased expression of CCND1 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Shikimic Acid results in increased expression of CCND1 mRNA]
Shikimic Acid results in increased expression of CCND1 mRNA; Shikimic Acid results in increased expression of CCND1 protein
CTD PMID:31048002 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
multiple interactions
ISO Shikimic Acid results in decreased expression of CDKN1A mRNA; Shikimic Acid results in decreased expression of CDKN1A protein
MIR300 mRNA affects the reaction [Shikimic Acid results in decreased expression of CDKN1A protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Shikimic Acid results in decreased expression of CDKN1A mRNA]
CTD PMID:31048002 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Fgf7 fibroblast growth factor 7 increases expression ISO Shikimic Acid results in increased expression of FGF7 mRNA CTD PMID:15265014 NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO Shikimic Acid results in increased expression of IGF1 mRNA CTD PMID:15265014 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Mir300 microRNA 300 increases expression
multiple interactions
ISO Shikimic Acid results in increased expression of MIR300 mRNA
MIR300 mRNA affects the reaction [Shikimic Acid results in decreased expression of CDKN1A protein]; MIR300 mRNA affects the reaction [Shikimic Acid results in decreased expression of NFKBIA mRNA]; MIR300 mRNA affects the reaction [Shikimic Acid results in decreased expression of NFKBIA protein]; MIR300 mRNA affects the reaction [Shikimic Acid results in increased expression of CCND1 protein]; MIR300 mRNA affects the reaction [Shikimic Acid results in increased expression of PCNA protein]; MIR300 mRNA affects the reaction [Shikimic Acid results in increased phosphorylation of RELA protein]
CTD PMID:31048002 NCBI chr 6:128,738,513...128,738,591
Ensembl chr 6:128,738,505...128,738,594
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression
multiple interactions
ISO Shikimic Acid results in decreased expression of NFKBIA mRNA
MIR300 mRNA affects the reaction [Shikimic Acid results in decreased expression of NFKBIA mRNA]; MIR300 mRNA affects the reaction [Shikimic Acid results in decreased expression of NFKBIA protein]; Shikimic Acid results in decreased expression of and results in decreased phosphorylation of NFKBIA protein
CTD PMID:31048002 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression
ISO MIR300 mRNA affects the reaction [Shikimic Acid results in increased expression of PCNA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Shikimic Acid results in increased expression of PCNA mRNA]
Shikimic Acid results in increased expression of PCNA mRNA; Shikimic Acid results in increased expression of PCNA protein
CTD PMID:31048002 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation
multiple interactions
ISO Shikimic Acid results in increased phosphorylation of RELA protein
MIR300 mRNA affects the reaction [Shikimic Acid results in increased phosphorylation of RELA protein]
CTD PMID:31048002 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
increases expression
ISO Shikimic Acid results in decreased expression of VEGFA mRNA
Shikimic Acid results in increased expression of VEGFA mRNA
CTD PMID:15265014 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19763
      chemical role 19330
        donor 18643
          Bronsted acid 18526
            oxoacid 18490
              carbon oxoacid 18372
                carboxylic acid 18367
                  monocarboxylic acid 17639
                    cyclohexenecarboxylic acid 16
                      3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid 0
                      4-coumaroylshikimic acid 0
                      5-[(E)-caffeoyl]shikimic acid 0
                      cyclohexenecarboxylate ester + 5
                      oseltamivir acid 0
                      perillic acid + 2
                      sedanonic acid 0
                      shikimic acid + 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19710
                    p-block element atom 19710
                      carbon group element atom 19631
                        carbon atom 19621
                          organic molecular entity 19621
                            organic group 18730
                              organic divalent group 18721
                                organodiyl group 18721
                                  carbonyl group 18670
                                    carbonyl compound 18670
                                      carboxylic acid 18367
                                        monocarboxylic acid 17639
                                          cyclohexenecarboxylic acid 16
                                            3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid 0
                                            4-coumaroylshikimic acid 0
                                            5-[(E)-caffeoyl]shikimic acid 0
                                            cyclohexenecarboxylate ester + 5
                                            oseltamivir acid 0
                                            perillic acid + 2
                                            sedanonic acid 0
                                            shikimic acid + 9
paths to the root