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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyclohexenecarboxylic acid
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Accession:CHEBI:23483 term browser browse the term
Synonyms:related_synonym: cyclohexenecarboxylic acids


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oseltamivir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Oseltamivir binds to and results in decreased activity of AR protein; Oseltamivir binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Ces1d carboxylesterase 1D affects hydrolysis ISO CES1 protein affects the hydrolysis of Oseltamivir CTD PMID:18983829 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Il6 interleukin 6 decreases response to substance ISO IL6 protein results in decreased susceptibility to Oseltamivir CTD PMID:17537833 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Oseltamivir binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
perillic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rhoa ras homolog family member A multiple interactions
increases expression
ISO Mevalonic Acid affects the reaction [perillic acid results in increased expression of RHOA protein] CTD PMID:12671036 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rhob ras homolog family member B multiple interactions
increases expression
ISO Mevalonic Acid affects the reaction [perillic acid results in increased expression of RHOB protein] CTD PMID:12671036 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301
JBrowse link
shikimic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd1 cyclin D1 multiple interactions
increases expression
ISO MIR300 mRNA affects the reaction [Shikimic Acid results in increased expression of CCND1 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Shikimic Acid results in increased expression of CCND1 mRNA]
Shikimic Acid results in increased expression of CCND1 mRNA; Shikimic Acid results in increased expression of CCND1 protein
CTD PMID:31048002 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
multiple interactions
ISO Shikimic Acid results in decreased expression of CDKN1A mRNA; Shikimic Acid results in decreased expression of CDKN1A protein
MIR300 mRNA affects the reaction [Shikimic Acid results in decreased expression of CDKN1A protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Shikimic Acid results in decreased expression of CDKN1A mRNA]
CTD PMID:31048002 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Fgf7 fibroblast growth factor 7 increases expression ISO Shikimic Acid results in increased expression of FGF7 mRNA CTD PMID:15265014 NCBI chr 3:118,315,859...118,368,464
Ensembl chr 3:118,317,761...118,366,872
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO Shikimic Acid results in increased expression of IGF1 mRNA CTD PMID:15265014 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Mir300 microRNA 300 increases expression
multiple interactions
ISO Shikimic Acid results in increased expression of MIR300 mRNA
MIR300 mRNA affects the reaction [Shikimic Acid results in decreased expression of CDKN1A protein]; MIR300 mRNA affects the reaction [Shikimic Acid results in decreased expression of NFKBIA mRNA]; MIR300 mRNA affects the reaction [Shikimic Acid results in decreased expression of NFKBIA protein]; MIR300 mRNA affects the reaction [Shikimic Acid results in increased expression of CCND1 protein]; MIR300 mRNA affects the reaction [Shikimic Acid results in increased expression of PCNA protein]; MIR300 mRNA affects the reaction [Shikimic Acid results in increased phosphorylation of RELA protein]
CTD PMID:31048002 NCBI chr 6:133,874,152...133,874,230
Ensembl chr 6:133,874,144...133,874,233
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression
multiple interactions
ISO Shikimic Acid results in decreased expression of NFKBIA mRNA
MIR300 mRNA affects the reaction [Shikimic Acid results in decreased expression of NFKBIA mRNA]; MIR300 mRNA affects the reaction [Shikimic Acid results in decreased expression of NFKBIA protein]; Shikimic Acid results in decreased expression of and results in decreased phosphorylation of NFKBIA protein
CTD PMID:31048002 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression
ISO MIR300 mRNA affects the reaction [Shikimic Acid results in increased expression of PCNA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Shikimic Acid results in increased expression of PCNA mRNA]
Shikimic Acid results in increased expression of PCNA mRNA; Shikimic Acid results in increased expression of PCNA protein
CTD PMID:31048002 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation
multiple interactions
ISO Shikimic Acid results in increased phosphorylation of RELA protein
MIR300 mRNA affects the reaction [Shikimic Acid results in increased phosphorylation of RELA protein]
CTD PMID:31048002 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
increases expression
ISO Shikimic Acid results in decreased expression of VEGFA mRNA
Shikimic Acid results in increased expression of VEGFA mRNA
CTD PMID:15265014 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      chemical role 19248
        donor 18377
          Bronsted acid 18240
            oxoacid 18192
              carbon oxoacid 18071
                carboxylic acid 18060
                  monocarboxylic acid 17406
                    cyclohexenecarboxylic acid 15
                      3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid 0
                      4-coumaroylshikimic acid 0
                      5-[(E)-caffeoyl]shikimic acid 0
                      cyclohexenecarboxylate ester + 4
                      oseltamivir acid 0
                      perillic acid + 2
                      sedanonic acid 0
                      shikimic acid + 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        monocarboxylic acid 17406
                                          cyclohexenecarboxylic acid 15
                                            3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid 0
                                            4-coumaroylshikimic acid 0
                                            5-[(E)-caffeoyl]shikimic acid 0
                                            cyclohexenecarboxylate ester + 4
                                            oseltamivir acid 0
                                            perillic acid + 2
                                            sedanonic acid 0
                                            shikimic acid + 9
paths to the root

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