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Accession:CHEBI:134689 term browser browse the term
Definition:A member of the class of azepinoindoles that is 1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one carrying additional 4-[(methylamino)methyl]phenyl and fluoro substituents at positions 2 and 8 respectively. It is an inhibitor of poly (ADP-ribose) polymerase and is used (as the camsylate salt) as monotherapy for advanced ovarian cancer and deleterious germline or somatic BRCA mutation.
Synonyms:exact_synonym: 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one
 related_synonym: AG-14447;   Formula=C19H18FN3O;   InChI=1S/C19H18FN3O/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24);   InChIKey=HMABYWSNWIZPAG-UHFFFAOYSA-N;   SMILES=C1(=CC2=C3C(=C1)NC(=C3CCNC2=O)C4=CC=C(C=C4)CNC)F
 xref: CAS:283173-50-2;   KEGG:D10079
 xref_mesh: MESH:C531549
 xref: PDBeChem:RPB;   PMID:25689628;   PMID:26438157;   PMID:27002934;   PMID:27087632;   PMID:27128213;   PMID:27228289;   PMID:27415012;   PMID:27515310;   PMID:27600766;   PMID:27702817;   PMID:27716873;   PMID:27866910;   PMID:27908594;   PMID:27940438;   PMID:28001384;   PMID:28057616;   PMID:28069724;   PMID:28205191;   Reaxys:11556434;   Wikipedia:Rucaparib
 cyclic_relationship: is_conjugate_base_of CHEBI:134695

show annotations for term's descendants       view all columns           Sort by:
rucaparib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Mki67 marker of proliferation Ki-67 JBrowse link 1 207,993,895 208,020,454 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Parp2 poly (ADP-ribose) polymerase 2 JBrowse link 15 27,739,416 27,749,650 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnks2 tankyrase 2 RGD:6480464

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19758
    role 19705
      application 19359
        pharmaceutical 19228
          drug 19228
            antineoplastic agent 16905
              rucaparib 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19758
    subatomic particle 19756
      composite particle 19756
        hadron 19756
          baryon 19756
            nucleon 19756
              atomic nucleus 19756
                atom 19756
                  main group element atom 19641
                    p-block element atom 19641
                      carbon group element atom 19532
                        carbon atom 19521
                          organic molecular entity 19521
                            organic group 18428
                              organic divalent group 18419
                                organodiyl group 18419
                                  carbonyl group 18309
                                    carbonyl compound 18309
                                      carboxylic acid 17978
                                        carboacyl group 17095
                                          univalent carboacyl group 17095
                                            carbamoyl group 16818
                                              carboxamide 16818
                                                lactam 7827
                                                  caprolactams 14
                                                    rucaparib 9
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.