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G |
Ar |
androgen receptor |
multiple interactions |
ISO |
ciclopirox binds to and results in decreased activity of AR protein |
CTD |
PMID:25752796 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
ciclopirox results in decreased expression of BIRC5 mRNA; ciclopirox results in decreased expression of BIRC5 protein |
CTD |
PMID:19589922 |
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
ciclopirox binds to and results in decreased activity of ESR1 protein |
CTD |
PMID:25752796 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Fkbp5 |
FKBP prolyl isomerase 5 |
multiple interactions |
ISO |
ciclopirox inhibits the reaction [Dexamethasone results in increased expression of FKBP5 mRNA] |
CTD |
PMID:19255438 |
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NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
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G |
Flt4 |
Fms related receptor tyrosine kinase 4 |
multiple interactions decreases expression increases degradation |
ISO |
FLT4 protein inhibits the reaction [ciclopirox results in decreased phosphorylation of MAPK1 protein]; FLT4 protein inhibits the reaction [ciclopirox results in decreased phosphorylation of MAPK3 protein] ciclopirox results in decreased expression of FLT4 protein [ciclopirox results in decreased expression of FLT4 protein] which results in decreased phosphorylation of MAPK1 protein; [ciclopirox results in decreased expression of FLT4 protein] which results in decreased phosphorylation of MAPK3 protein ciclopirox results in increased degradation of FLT4 protein |
CTD |
PMID:21217783 |
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NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions increases stability |
EXP ISO |
ciclopirox results in increased expression of and results in increased localization of HIF1A protein ciclopirox results in increased stability of HIF1A protein |
CTD |
PMID:14600837 PMID:15741220 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hmox1 |
heme oxygenase 1 |
decreases degradation |
ISO |
ciclopirox results in decreased degradation of HMOX1 protein |
CTD |
PMID:19384570 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
multiple interactions |
ISO |
ciclopirox inhibits the reaction [Terfenadine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]]; ciclopirox promotes the reaction [KCNH2 protein results in increased transport of Thallium] |
CTD |
PMID:21158687 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases phosphorylation multiple interactions |
ISO |
ciclopirox results in decreased phosphorylation of MAPK1 protein [ciclopirox results in decreased expression of FLT4 protein] which results in decreased phosphorylation of MAPK1 protein; ciclopirox promotes the reaction [U 0126 results in decreased phosphorylation of MAPK1 protein] FLT4 protein inhibits the reaction [ciclopirox results in decreased phosphorylation of MAPK1 protein] |
CTD |
PMID:21217783 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases phosphorylation |
ISO |
FLT4 protein inhibits the reaction [ciclopirox results in decreased phosphorylation of MAPK3 protein] [Ciclopirox results in decreased expression of FLT4 protein] which results in decreased phosphorylation of MAPK3 protein; Ciclopirox promotes the reaction [U 0126 results in decreased phosphorylation of MAPK3 protein] |
CTD |
PMID:21217783 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapt |
microtubule-associated protein tau |
decreases expression |
ISO |
ciclopirox results in decreased expression of MAPT protein |
CTD |
PMID:16930453 |
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NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
decreases activity decreases expression |
ISO |
ciclopirox results in decreased activity of NR3C1 protein ciclopirox results in decreased expression of NR3C1 protein |
CTD |
PMID:19255438 |
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NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Pgr |
progesterone receptor |
multiple interactions |
ISO |
ciclopirox binds to and results in decreased activity of PGR protein |
CTD |
PMID:25752796 |
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NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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G |
Rrm2 |
ribonucleotide reductase regulatory subunit M2 |
decreases activity |
ISO |
ciclopirox results in decreased activity of RRM2 protein |
CTD |
PMID:19589922 |
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NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
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G |
Tp53 |
tumor protein p53 |
affects activity |
ISO |
Ciclopirox affects the activity of TP53 protein |
CTD |
PMID:35435491 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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