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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diazepine
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Accession:CHEBI:47918 term browser browse the term
Synonyms:related_synonym: diazepines


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CX-5461 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca2 BRCA2, DNA repair associated affects response to substance
multiple interactions		 ISO BRCA2 protein affects the susceptibility to CX 5461
BRCA2 protein affects the reaction [CX 5461 results in increased expression of TP53BP1 protein]; BRCA2 protein affects the reaction [CX 5461 results in increased phosphorylation of RPA2 protein]		 CTD PMID:28211448 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567 		JBrowse link
G Chek1 checkpoint kinase 1 increases phosphorylation ISO CX 5461 results in increased phosphorylation of CHEK1 protein CTD PMID:28211448 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation ISO CX 5461 results in increased phosphorylation of CHEK2 protein CTD PMID:28211448 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO CX 5461 results in increased expression of H2AX protein CTD PMID:28211448 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO CX 5461 results in increased cleavage of PARP1 protein CTD PMID:32799625 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rad51 RAD51 recombinase increases expression ISO CX 5461 results in increased expression of RAD51 protein CTD PMID:28211448 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rpa2 replication protein A2 increases phosphorylation
multiple interactions		 ISO CX 5461 results in increased phosphorylation of RPA2 protein
BRCA2 protein affects the reaction [CX 5461 results in increased phosphorylation of RPA2 protein]		 CTD PMID:28211448 NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 multiple interactions
increases expression		 ISO BRCA2 protein affects the reaction [CX 5461 results in increased expression of TP53BP1 protein] CTD PMID:28211448 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822 		JBrowse link
suvorexant term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO suvorexant inhibits the reaction [Morphine results in increased expression of CREB1 protein] CTD PMID:33609567 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A increases expression ISO suvorexant results in increased expression of GRIN2A protein CTD PMID:33609567 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein] CTD PMID:33609567 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein] CTD PMID:33609567 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      atom 19806
        nonmetal atom 19744
          nitrogen atom 18933
            nitrogen molecular entity 18933
              organonitrogen compound 18783
                organonitrogen heterocyclic compound 18126
                  diazepine 12
                    1-beta-D-ribofuranosyl-1,3-dihydro-2H-1,3-diazepin-2-one 0
                    4,5-dihydrothiazolo[2,3-d][1,5]benzodiazepin-11-ium-6-carboxaldehyde 0
                    6-epi-monanchorin 0
                    7-(2-chloro-6-fluorophenyl)-5-methyl-6,7-dihydro-1H-1,4-diazepine-2,3-dicarbonitrile 0
                    CX-5461 8
                    N-(2-furylmethyl)-3-[(2s,5as,8ar)-1-methyl-5-oxodecahydropyrrolo[3,2-e][1,4]diazepin-2-yl]propanamide 0
                    N-Benzyl-3-[(2S,5aS,8aR)-6-(1H-imidazol-2-ylmethyl)-1-methyl-5-oxodecahydropyrrolo[3,2-E][1,4]diazepin-2-yl]propanamide 0
                    homofenazine 0
                    suvorexant 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  organic heteromonocyclic compound 17773
                                    diazepine 12
                                      1-beta-D-ribofuranosyl-1,3-dihydro-2H-1,3-diazepin-2-one 0
                                      4,5-dihydrothiazolo[2,3-d][1,5]benzodiazepin-11-ium-6-carboxaldehyde 0
                                      6-epi-monanchorin 0
                                      7-(2-chloro-6-fluorophenyl)-5-methyl-6,7-dihydro-1H-1,4-diazepine-2,3-dicarbonitrile 0
                                      CX-5461 8
                                      N-(2-furylmethyl)-3-[(2s,5as,8ar)-1-methyl-5-oxodecahydropyrrolo[3,2-e][1,4]diazepin-2-yl]propanamide 0
                                      N-Benzyl-3-[(2S,5aS,8aR)-6-(1H-imidazol-2-ylmethyl)-1-methyl-5-oxodecahydropyrrolo[3,2-E][1,4]diazepin-2-yl]propanamide 0
                                      homofenazine 0
                                      suvorexant 4
paths to the root