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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:suvorexant
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Accession:CHEBI:82698 term browser browse the term
Definition:An aromatic amide obtained by formal condensation of the carboxy group of 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid with the secondary amino group of 5-chloro-2-[(5R)-5-methyl-1,4-diazepan-1-yl]-1,3-benzoxazole. An orexin receptor antagonist used for the management of insomnia.
Synonyms:exact_synonym: [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone
 related_synonym: BELSOMRA;   Formula=C23H23ClN6O2;   InChI=1S/C23H23ClN6O2/c1-15-3-5-20(30-25-8-9-26-30)18(13-15)22(31)29-12-11-28(10-7-16(29)2)23-27-19-14-17(24)4-6-21(19)32-23/h3-6,8-9,13-14,16H,7,10-12H2,1-2H3/t16-/m1/s1;   InChIKey=JYTNQNCOQXFQPK-MRXNPFEDSA-N;   MK-4305;   MK4305;   SMILES=C[C@@H]1CCN(CCN1C(=O)c1cc(C)ccc1-n1nccn1)c1nc2cc(Cl)ccc2o1
 xref: CAS:1030377-33-3;   Drug_Central:4881;   KEGG:D10082
 xref_mesh: MESH:C551624
 xref: PMID:23372274;   PMID:23692283;   PMID:24368893;   PMID:24488306;   PMID:24550770;   PMID:24680372;   PMID:24757363;   PMID:25167596;   PMID:25197807;   PMID:25227290;   PMID:25231363;   PMID:25291725;   PMID:25299902;   Reaxys:18339082;   Wikipedia:Suvorexant



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suvorexant term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO suvorexant inhibits the reaction [Morphine results in increased expression of CREB1 protein] CTD PMID:33609567 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A increases expression ISO suvorexant results in increased expression of GRIN2A protein CTD PMID:33609567 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein] CTD PMID:33609567 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein] CTD PMID:33609567 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20024
      biological role 20023
        pharmacological role 19105
          antagonist 16745
            orexin receptor antagonist 4
              suvorexant 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19971
                    p-block element atom 19971
                      carbon group element atom 19894
                        carbon atom 19887
                          organic molecular entity 19887
                            organic molecule 19835
                              organic cyclic compound 19589
                                organic heterocyclic compound 18857
                                  heteroarene 16612
                                    monocyclic heteroarene 13622
                                      azole 12849
                                        triazoles 3716
                                          suvorexant 4
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