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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:suvorexant
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Accession:CHEBI:82698 term browser browse the term
Definition:An aromatic amide obtained by formal condensation of the carboxy group of 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid with the secondary amino group of 5-chloro-2-[(5R)-5-methyl-1,4-diazepan-1-yl]-1,3-benzoxazole. An orexin receptor antagonist used for the management of insomnia.
Synonyms:exact_synonym: [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone
 related_synonym: BELSOMRA;   Formula=C23H23ClN6O2;   InChI=1S/C23H23ClN6O2/c1-15-3-5-20(30-25-8-9-26-30)18(13-15)22(31)29-12-11-28(10-7-16(29)2)23-27-19-14-17(24)4-6-21(19)32-23/h3-6,8-9,13-14,16H,7,10-12H2,1-2H3/t16-/m1/s1;   InChIKey=JYTNQNCOQXFQPK-MRXNPFEDSA-N;   MK-4305;   MK4305;   SMILES=C[C@@H]1CCN(CCN1C(=O)c1cc(C)ccc1-n1nccn1)c1nc2cc(Cl)ccc2o1
 xref: CAS:1030377-33-3;   Drug_Central:4881;   KEGG:D10082
 xref_mesh: MESH:C551624
 xref: PMID:23372274;   PMID:23692283;   PMID:24368893;   PMID:24488306;   PMID:24550770;   PMID:24680372;   PMID:24757363;   PMID:25167596;   PMID:25197807;   PMID:25227290;   PMID:25231363;   PMID:25291725;   PMID:25299902;   Reaxys:18339082;   Wikipedia:Suvorexant


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suvorexant term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO suvorexant inhibits the reaction [Morphine results in increased expression of CREB1 protein] CTD PMID:33609567 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A increases expression ISO suvorexant results in increased expression of GRIN2A protein CTD PMID:33609567 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein] CTD PMID:33609567 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein] CTD PMID:33609567 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        pharmacological role 19030
          antagonist 17213
            orexin receptor antagonist 4
              suvorexant 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            organic molecule 19658
                              organic cyclic compound 19471
                                organic heterocyclic compound 18862
                                  heteroarene 17114
                                    monocyclic heteroarene 14850
                                      azole 14355
                                        triazoles 8120
                                          suvorexant 4
paths to the root