Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chloral hydrate
go back to main search page
Accession:CHEBI:28142 term browser browse the term
Definition:An organochlorine compound that is the hydrate of trichloroacetaldehyde.
Synonyms:exact_synonym: 2,2,2-trichloroethane-1,1-diol
 related_synonym: 1,1,1-trichloro-2,2-dihydroxyethane;   1,1,1-trichloro-2,2-ethanediol;   2,2,2-trichloro-1,1-ethanediol;   Aquachloral Supprettes;   Chloralhydrat;   Formula=C2H3Cl3O2;   InChI=1S/C2H3Cl3O2/c3-2(4,5)1(6)7/h1,6-7H;   InChIKey=RNFNDJAIBTYOQL-UHFFFAOYSA-N;   Noctec;   SMILES=OC(O)C(Cl)(Cl)Cl;   Somnote;   Trichloracetaldehyd-hydrat;   chloral monohydrate;   knockout drops;   trichloroacetaldehyde hydrate
 alt_id: CHEBI:23105;   CHEBI:3600
 xref: Beilstein:1698497;   CAS:302-17-0;   DrugBank:DB01563;   Drug_Central:586;   Gmelin:101369;   KEGG:C06899;   KEGG:D00265
 xref_mesh: MESH:D002697
 xref: MetaCyc:CPD0-1476;   PPDB:2987;   UM-BBD_compID:c0011;   VSDB:2987


show annotations for term's descendants           Sort by:
chloral hydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions ISO
EXP		 [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin
[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to glycolaldehyde; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Pyruvaldehyde		 CTD PMID:18272654 PMID:21334317 PMID:21376711 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP Chloral Hydrate inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA] CTD PMID:7513451 NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP Chloral Hydrate inhibits the reaction [Phenobarbital results in increased expression of CYP2B2 mRNA] CTD PMID:7513451 NCBI chr 1:90,722,243...90,736,272
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases chemical synthesis
multiple interactions		 EXP CYP2E1 protein results in increased chemical synthesis of Chloral Hydrate
[CYP2E1 protein results in increased metabolism of Trichloroethylene] which results in increased chemical synthesis of Chloral Hydrate		 CTD PMID:1739413 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Chloral Hydrate inhibits the reaction [Cocaine results in increased expression of FOS protein] CTD PMID:15219685 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions ISO Chloral Hydrate inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein] CTD PMID:10683198 NCBI chr20:1,469,779...1,499,352
Ensembl chr20:1,464,534...1,493,994 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Chloral Hydrate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr14:37,451,218...37,587,458
Ensembl chr14:37,097,279...37,228,944 		JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO Chloral Hydrate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr14:36,434,339...36,917,920
Ensembl chr14:36,080,393...36,548,948 		JBrowse link
G Gast gastrin multiple interactions EXP Chloral Hydrate inhibits the reaction [GAST protein results in increased secretion of Histamine] CTD PMID:10864877 NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,264,832...85,267,496 		JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression
increases expression		 EXP Chloral Hydrate results in decreased expression of GJA1 mRNA; Chloral Hydrate results in decreased expression of GJA1 protein
Chloral Hydrate results in increased expression of GJA1 protein		 CTD PMID:21243523 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gjb2 gap junction protein, beta 2 decreases expression
increases expression		 EXP Chloral Hydrate results in decreased expression of GJB2 mRNA
Chloral Hydrate results in increased expression of GJB2 protein		 CTD PMID:21243523 NCBI chr15:35,375,977...35,393,817
Ensembl chr15:31,260,357...31,278,177 		JBrowse link
G Glra1 glycine receptor, alpha 1 multiple interactions ISO Chloral Hydrate promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein] CTD PMID:10683198 NCBI chr10:40,128,284...40,228,612
Ensembl chr10:39,629,459...39,727,162 		JBrowse link
G Hmox1 heme oxygenase 1 affects expression EXP Chloral Hydrate affects the expression of HMOX1 mRNA CTD PMID:22954530 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 EXP Chloral Hydrate results in increased expression of IL1B mRNA
Ozone inhibits the reaction [Chloral Hydrate results in increased expression of IL1B mRNA]		 CTD PMID:15207037 PMID:15207038 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression EXP Chloral Hydrate results in increased expression of IL6 mRNA CTD PMID:15207037 PMID:15207038 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO Chloral Hydrate inhibits the reaction [SLC2A1 protein results in increased transport of Glucose] CTD PMID:18455367 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19879
    role 19850
      biological role 19848
        xenobiotic 18730
          chloral hydrate 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19879
    subatomic particle 19877
      composite particle 19877
        hadron 19877
          baryon 19877
            nucleon 19877
              atomic nucleus 19877
                atom 19877
                  main group element atom 19816
                    p-block element atom 19816
                      chalcogen 19569
                        oxygen atom 19541
                          oxygen molecular entity 19541
                            hydroxides 19350
                              organic hydroxy compound 18955
                                polyol 11701
                                  diol 3944
                                    ethanediol 165
                                      chloral hydrate 16
paths to the root