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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cyclohexenecarboxylic acid
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Accession:CHEBI:23483 term browser browse the term
Synonyms:related_synonym: cyclohexenecarboxylic acids
 cyclic_relationship: is_conjugate_acid_of CHEBI:36126


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oseltamivir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Oseltamivir binds to and results in decreased activity of AR protein; Oseltamivir binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Ces1d carboxylesterase 1D affects hydrolysis
multiple interactions
increases metabolic processing		 ISO CES1 protein affects the hydrolysis of Oseltamivir
7,8-dihydromethysticin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; [CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate; [hirsutine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [mitragynine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [paynantheine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [Plant Extracts results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [speciogynine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; desmethoxyyangonin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; dihydrokavain inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; kavain inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; methysticin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; yangonin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]		 CTD PMID:18983829 PMID:35278473 PMID:37716419 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Il6 interleukin 6 decreases response to substance ISO IL6 protein results in decreased susceptibility to Oseltamivir CTD PMID:17537833 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Oseltamivir binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Oseltamivir results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
perillic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rhoa ras homolog family member A multiple interactions
increases expression		 ISO Mevalonic Acid affects the reaction [perillic acid results in increased expression of RHOA protein] CTD PMID:12671036 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rhob ras homolog family member B multiple interactions
increases expression		 ISO Mevalonic Acid affects the reaction [perillic acid results in increased expression of RHOB protein] CTD PMID:12671036 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108 		JBrowse link
shikimic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd1 cyclin D1 multiple interactions
increases expression		 ISO MIR300 mRNA affects the reaction [Shikimic Acid results in increased expression of CCND1 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Shikimic Acid results in increased expression of CCND1 mRNA]
Shikimic Acid results in increased expression of CCND1 mRNA; Shikimic Acid results in increased expression of CCND1 protein		 CTD PMID:31048002 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
multiple interactions		 ISO Shikimic Acid results in decreased expression of CDKN1A mRNA; Shikimic Acid results in decreased expression of CDKN1A protein
MIR300 mRNA affects the reaction [Shikimic Acid results in decreased expression of CDKN1A protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Shikimic Acid results in decreased expression of CDKN1A mRNA]		 CTD PMID:31048002 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Fgf7 fibroblast growth factor 7 increases expression ISO Shikimic Acid results in increased expression of FGF7 mRNA CTD PMID:15265014 NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO Shikimic Acid results in increased expression of IGF1 mRNA CTD PMID:15265014 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Mir300 microRNA 300 increases expression
multiple interactions		 ISO Shikimic Acid results in increased expression of MIR300 mRNA
MIR300 mRNA affects the reaction [Shikimic Acid results in decreased expression of CDKN1A protein]; MIR300 mRNA affects the reaction [Shikimic Acid results in decreased expression of NFKBIA mRNA]; MIR300 mRNA affects the reaction [Shikimic Acid results in decreased expression of NFKBIA protein]; MIR300 mRNA affects the reaction [Shikimic Acid results in increased expression of CCND1 protein]; MIR300 mRNA affects the reaction [Shikimic Acid results in increased expression of PCNA protein]; MIR300 mRNA affects the reaction [Shikimic Acid results in increased phosphorylation of RELA protein]		 CTD PMID:31048002 NCBI chr 6:128,738,513...128,738,591
Ensembl chr 6:128,738,505...128,738,594 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression
multiple interactions		 ISO Shikimic Acid results in decreased expression of NFKBIA mRNA
MIR300 mRNA affects the reaction [Shikimic Acid results in decreased expression of NFKBIA mRNA]; MIR300 mRNA affects the reaction [Shikimic Acid results in decreased expression of NFKBIA protein]; Shikimic Acid results in decreased expression of and results in decreased phosphorylation of NFKBIA protein		 CTD PMID:31048002 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression		 ISO MIR300 mRNA affects the reaction [Shikimic Acid results in increased expression of PCNA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Shikimic Acid results in increased expression of PCNA mRNA]
Shikimic Acid results in increased expression of PCNA mRNA; Shikimic Acid results in increased expression of PCNA protein		 CTD PMID:31048002 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation
multiple interactions		 ISO Shikimic Acid results in increased phosphorylation of RELA protein
MIR300 mRNA affects the reaction [Shikimic Acid results in increased phosphorylation of RELA protein]		 CTD PMID:31048002 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
increases expression		 ISO Shikimic Acid results in decreased expression of VEGFA mRNA
Shikimic Acid results in increased expression of VEGFA mRNA		 CTD PMID:15265014 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      group 19765
        inorganic group 19360
          oxo group 18869
            organic oxo compound 18869
              carbonyl compound 18869
                carboxylic acid 18609
                  monocarboxylic acid 17984
                    cyclohexenecarboxylic acid 16
                      3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid 0
                      4-coumaroylshikimic acid 0
                      4-oxocyclohex-2-ene-1-carboxylic acid 0
                      5-[(E)-caffeoyl]shikimic acid 0
                      cyclohexenecarboxylate ester + 5
                      oseltamivir acid 0
                      perillic acid + 2
                      sedanonic acid 0
                      shikimic acid + 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      monocarboxylic acid 17984
                                        cyclohexenecarboxylic acid 16
                                          3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid 0
                                          4-coumaroylshikimic acid 0
                                          4-oxocyclohex-2-ene-1-carboxylic acid 0
                                          5-[(E)-caffeoyl]shikimic acid 0
                                          cyclohexenecarboxylate ester + 5
                                          oseltamivir acid 0
                                          perillic acid + 2
                                          sedanonic acid 0
                                          shikimic acid + 9
paths to the root