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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Beta-Solamarine
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Accession:CHEBI:189918 term browser browse the term
Synonyms:exact_synonym: (2S,3R,4R,5R,6S)-2-[(2R,3S,4S,5R,6R)-4-hydroxy-2-(hydroxymethyl)-6-[(1S,2S,4S,5'S,6S,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-piperidine]-16-yl]oxy-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol
 related_synonym: Formula=C45H73NO15;   InChI=1S/C45H73NO15/c1-19-9-14-45(46-17-19)20(2)30-28(61-45)16-27-25-8-7-23-15-24(10-12-43(23,5)26(25)11-13-44(27,30)6)57-42-39(60-41-36(53)34(51)32(49)22(4)56-41)37(54)38(29(18-47)58-42)59-40-35(52)33(50)31(48)21(3)55-40/h7,19-22,24-42,46-54H,8-18H2,1-6H3/t19-,20-,21-,22-,24-,25+,26-,27-,28-,29+,30-,31-,32-,33+,34+,35+,36+,37-,38+,39+,40-,41-,42+,43-,44-,45-/m0/s1;   InChIKey=MBWUSSKCCUMJHO-SXCAMOPPSA-N;   SMILES=O1[C@@]2([C@@]([C@@]3([C@]([C@]4([C@](CC3)([C@@]5(C(=CC4)C[C@@H](O[C@@H]6O[C@@H]([C@@H](O[C@@H]7O[C@H]([C@H](O)[C@@H](O)[C@H]7O)C)[C@H](O)[C@H]6O[C@@H]8O[C@H]([C@H](O)[C@@H](O)[C@H]8O)C)CO)CC5)C)[H])[H])(C2)[H])C)([C@@H]([C@@]19NC[C@H](CC9)C)C)[H])[H]
 xref: CAS:3671-38-3;   Chemspider:147795
 xref_mesh: MESH:C026609


show annotations for term's descendants           Sort by:
Beta-Solamarine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO beta-solamarine results in increased expression of BAX protein
beta-solamarine promotes the reaction [Cisplatin results in increased expression of BAX protein]		 CTD PMID:17619073 PMID:20647040 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO beta-solamarine results in decreased expression of BCL2 protein CTD PMID:17619073 PMID:20647040 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO beta-solamarine results in decreased expression of BCL2L1 protein CTD PMID:17619073 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
multiple interactions		 ISO beta-solamarine results in increased activity of CASP3 protein
beta-solamarine results in increased cleavage of CASP3 protein
beta-solamarine promotes the reaction [Cisplatin results in increased activity of CASP3 protein]		 CTD PMID:17619073 PMID:20647040 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity		 ISO beta-solamarine promotes the reaction [Cisplatin results in increased activity of CASP8 protein]
beta-solamarine results in increased activity of CASP8 protein		 CTD PMID:17619073 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases cleavage		 ISO beta-solamarine promotes the reaction [Cisplatin results in increased activity of CASP9 protein]
beta-solamarine results in increased activity of CASP9 protein
beta-solamarine results in increased cleavage of CASP9 protein		 CTD PMID:17619073 PMID:20647040 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ctsb cathepsin B affects localization ISO beta-solamarine affects the localization of CTSB protein CTD PMID:20647040 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Fadd Fas associated via death domain increases expression ISO beta-solamarine results in increased expression of FADD protein CTD PMID:17619073 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO beta-solamarine results in increased expression of FAS protein CTD PMID:17619073 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO beta-solamarine results in increased expression of TNFRSF1A protein CTD PMID:17619073 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO beta-solamarine results in increased expression of TRADD protein CTD PMID:17619073 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        biochemical role 19529
          metabolite 19515
            saponin 486
              steroid saponin 358
                Beta-Solamarine 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  carbohydrates and carbohydrate derivatives 15285
                                    carbohydrate 15285
                                      carbohydrate derivative 14290
                                        glycosyl compound 13048
                                          glycoside 11832
                                            saponin 486
                                              steroid saponin 358
                                                Beta-Solamarine 11
paths to the root