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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:propacetamol
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Accession:CHEBI:135089 term browser browse the term
Synonyms:related_synonym: Formula=C14H20N2O3;   InChI=1S/C14H20N2O3/c1-4-16(5-2)10-14(18)19-13-8-6-12(7-9-13)15-11(3)17/h6-9H,4-5,10H2,1-3H3,(H,15,17);   InChIKey=QTGAJCQTLIRCFL-UHFFFAOYSA-N;   SMILES=O(C(CN(CC)CC)=O)C1=CC=C(C=C1)NC(C)=O;   proparacetamol
 xref: CAS:66532-85-2;   Drug_Central:2290
 xref_mesh: MESH:C063776


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propacetamol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO propacetamol results in increased expression of BAX protein
kaempferol inhibits the reaction [propacetamol results in increased expression of BAX protein]		 CTD PMID:29574133 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions		 ISO propacetamol results in increased cleavage of CASP3 protein
kaempferol inhibits the reaction [propacetamol results in increased cleavage of CASP3 protein]		 CTD PMID:29574133 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases activity
multiple interactions		 ISO propacetamol results in decreased activity of CAT protein
kaempferol inhibits the reaction [propacetamol results in decreased activity of CAT protein]		 CTD PMID:29574133 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression
multiple interactions		 ISO propacetamol results in increased expression of CYP2E1 protein
kaempferol inhibits the reaction [propacetamol results in increased expression of CYP2E1 protein]		 CTD PMID:29574133 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit affects expression
multiple interactions		 ISO propacetamol affects the expression of GCLC protein
kaempferol affects the reaction [propacetamol affects the expression of GCLC protein]		 CTD PMID:29574133 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity		 ISO kaempferol inhibits the reaction [propacetamol results in increased activity of GPT protein] CTD PMID:29574133 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hmox1 heme oxygenase 1 affects expression
multiple interactions		 ISO propacetamol affects the expression of HMOX1 protein
kaempferol affects the reaction [propacetamol affects the expression of HMOX1 protein]		 CTD PMID:29574133 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO kaempferol inhibits the reaction [propacetamol results in increased expression of IL6 protein] CTD PMID:29574133 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO kaempferol inhibits the reaction [propacetamol results in increased phosphorylation of MAPK1 protein] CTD PMID:29574133 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO kaempferol inhibits the reaction [propacetamol results in increased phosphorylation of MAPK3 protein] CTD PMID:29574133 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects expression
multiple interactions		 ISO propacetamol affects the expression of NFE2L2 protein
kaempferol affects the reaction [propacetamol affects the expression of NFE2L2 protein]		 CTD PMID:29574133 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 increases expression
multiple interactions		 ISO propacetamol results in increased expression of RIPK1 protein
kaempferol inhibits the reaction [propacetamol results in increased expression of RIPK1 protein]		 CTD PMID:29574133 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO propacetamol results in increased expression of TNF protein
kaempferol inhibits the reaction [propacetamol results in increased expression of TNF protein]		 CTD PMID:29574133 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases expression
multiple interactions		 ISO propacetamol results in decreased expression of UGT1A1 protein
kaempferol inhibits the reaction [propacetamol results in decreased expression of UGT1A1 protein]		 CTD PMID:29574133 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        NMR chemical shift reference compound 18065
          ammonia 17865
            organic amino compound 17865
              amino acid 16057
                alpha-amino acid 13932
                  alpha-amino acid ester 287
                    propacetamol 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17865
                                        amino acid 16057
                                          alpha-amino acid 13932
                                            alpha-amino acid ester 287
                                              propacetamol 14
paths to the root