Gria1 (glutamate ionotropic receptor AMPA type subunit 1) - Rat Genome Database

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Gene: Gria1 (glutamate ionotropic receptor AMPA type subunit 1) Rattus norvegicus
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Symbol: Gria1
Name: glutamate ionotropic receptor AMPA type subunit 1
RGD ID: 621531
Description: Enables several functions, including enzyme binding activity; signaling receptor binding activity; and transmitter-gated monoatomic ion channel activity. Involved in several processes, including central nervous system development; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including dendrite; endosome membrane; and neuronal cell body membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic active zone membrane. Used to study cocaine dependence; hyperhomocysteinemia; morphine dependence; and withdrawal disorder. Biomarker of several diseases, including alcohol use disorder; amphetamine abuse; brain disease (multiple); cocaine abuse; and drug dependence (multiple). Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 67; autosomal recessive intellectual developmental disorder 76; and epilepsy. Orthologous to human GRIA1 (glutamate ionotropic receptor AMPA type subunit 1); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; amyotrophic lateral sclerosis pathway; INTERACTS WITH (+)-pilocarpine; (-)-anisomycin; (S)-AMPA.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AMPA-selective glutamate receptor 1; GluA1; gluR-1; gluR-A; gluR-K1; GluR1; glutamate receptor 1; glutamate receptor A; glutamate receptor subunit GluR1; glutamate receptor, ionotropic, AMPA 1; glutamate receptor, ionotropic, AMPA1 (alpha 1)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81041,710,540 - 42,030,105 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1041,711,080 - 42,030,309 (+)EnsemblGRCr8
mRatBN7.21041,210,713 - 41,527,283 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1041,210,713 - 41,527,283 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1045,861,160 - 46,177,214 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01045,351,373 - 45,667,433 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01040,855,030 - 41,171,065 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01042,441,723 - 42,760,200 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1042,614,713 - 42,760,200 (+)Ensemblrn6Rnor6.0
Rnor_5.01042,257,736 - 42,571,220 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41042,613,359 - 42,616,610 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1040,506,762 - 40,822,664 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-anisomycin  (EXP)
(S)-AMPA  (EXP)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-bromopropane  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
2-tert-butylhydroquinone  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (EXP)
6-Cyano-7-nitroquinoxaline-2,3-dione  (EXP)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic acid  (EXP)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
azoxystrobin  (EXP)
Bay-K-8644  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzoates  (EXP)
beta-naphthoflavone  (EXP)
bicuculline  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
capsaicin  (EXP)
carbon nanotube  (ISO)
ceftriaxone  (EXP)
celecoxib  (ISO)
CGP 52608  (ISO)
chaetocin  (EXP)
chlorpyrifos  (EXP)
citalopram  (ISO)
Citreoviridin  (ISO)
cocaine  (EXP,ISO)
cordycepin  (ISO)
corosolic acid  (ISO)
corticosterone  (ISO)
corydaline  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cypermethrin  (ISO)
decabromodiphenyl ether  (EXP)
Diacetoxyscirpenol  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dichloroacetic acid  (ISO)
dieldrin  (EXP)
dizocilpine  (EXP)
dizocilpine maleate  (EXP)
domoic acid  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP,IEP,ISO)
Evodiamine  (EXP)
excitatory amino acid agonist  (EXP)
flavonoids  (EXP)
fluoxetine  (EXP,ISO)
flurazepam  (EXP)
Gastrodin  (ISO)
genistein  (EXP,ISO)
glutamate(2-)  (EXP)
glutamic acid  (EXP)
glycine  (EXP)
glyphosate  (EXP)
haloperidol  (EXP)
imidacloprid  (EXP)
imipramine  (ISO)
immunological adjuvant  (ISO)
istradefylline  (EXP)
kainic acid  (EXP,ISO)
ketamine  (EXP,ISO)
KN-93  (EXP)
L-ascorbic acid  (ISO)
lactacystin  (EXP)
lead diacetate  (ISO)
lead(0)  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
maleic acid  (ISO)
melatonin  (EXP)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
minocycline  (EXP)
morphine  (EXP,ISO)
N,N-diethyl-m-toluamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (EXP)
naloxone  (EXP)
nickel atom  (EXP)
nicotine  (EXP)
nifedipine  (ISO)
nitrofen  (EXP)
nitroglycerin  (EXP)
ochratoxin A  (EXP)
Ondansetron  (EXP)
ozone  (ISO)
paclitaxel  (EXP)
Panaxynol  (ISO)
panobinostat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
permethrin  (EXP,ISO)
pirinixic acid  (ISO)
poly(cytidylic acid)  (EXP)
progesterone  (ISO)
quinpirole  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rimonabant  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sterigmatocystin  (EXP)
sulfur dioxide  (EXP)
tacrine  (ISO)
tadalafil  (ISO)
tetrachloromethane  (EXP)
tetraethylammonium  (EXP)
tetrahydropalmatine  (EXP)
tetrodotoxin  (EXP)
thiabendazole  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topiramate  (EXP)
triazolam  (ISO)
tributylstannane  (EXP)
trichostatin A  (ISO)
U0126  (EXP)
urethane  (EXP)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vorinostat  (ISO)
WIN 55212-2  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to pain  (IEP)
calcium-mediated signaling  (IEA)
cellular response to amine stimulus  (IEP)
cellular response to amino acid stimulus  (IEP)
cellular response to ammonium ion  (ISO)
cellular response to brain-derived neurotrophic factor stimulus  (IDA,IEP)
cellular response to dsRNA  (IEP)
cellular response to glycine  (IEP)
cellular response to growth factor stimulus  (IEP)
cellular response to L-glutamate  (IEP)
cellular response to peptide hormone stimulus  (IEP)
cerebral cortex development  (IEP)
chemical synaptic transmission  (ISO)
conditioned place preference  (IMP)
ionotropic glutamate receptor signaling pathway  (IEA,NAS)
long-term memory  (IEA,IMP,ISO)
long-term synaptic depression  (ISO)
long-term synaptic potentiation  (IEP)
modulation of chemical synaptic transmission  (IBA,IDA)
monoatomic ion transmembrane transport  (IEA)
monoatomic ion transport  (IEA)
neuronal action potential  (IMP)
positive regulation of excitatory postsynaptic potential  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of locomotion involved in locomotory behavior  (IMP)
positive regulation of membrane potential  (IMP)
positive regulation of synaptic transmission  (IMP)
receptor internalization  (IDA,IEA,ISO)
regulation of monoatomic ion transmembrane transport  (IMP)
regulation of postsynaptic membrane potential  (IEA)
regulation of presynaptic membrane potential  (IEA)
regulation of receptor recycling  (IEA,IMP)
regulation of signaling  (IEA)
regulation of synaptic plasticity  (IMP,NAS)
response to arsenic-containing substance  (IEP)
response to cocaine  (IEP)
response to electrical stimulus  (IEP)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to fungicide  (IEA,IEP)
response to lithium ion  (IEA,IEP)
response to morphine  (IEP,IMP)
response to nutrient levels  (IDA)
response to peptide hormone  (IEP)
response to psychosocial stress  (IEP)
response to sucrose  (IDA)
response to toxic substance  (IMP)
response to xenobiotic stimulus  (IEP)
spinal cord development  (IEP)
synapse assembly  (IEA,ISO)
synaptic transmission, glutamatergic  (IBA,NAS)

Cellular Component
AMPA glutamate receptor complex  (IBA,IDA,IEA,ISO)
asymmetric synapse  (IDA)
axonal spine  (IEA,ISO)
cell body  (IEA,ISO)
cell surface  (IDA,IEA,ISO)
cell-cell junction  (IDA)
cytosol  (IDA)
dendrite  (IDA,IEA,ISO,ISS)
dendrite membrane  (IDA,IEA,ISO)
dendritic shaft  (IDA,IEA)
dendritic spine  (IBA,IDA,IEA,ISO)
dendritic spine membrane  (IEA,ISO)
early endosome  (IDA)
early endosome membrane  (IDA,IEA)
endoplasmic reticulum  (IEA,ISO)
endoplasmic reticulum membrane  (IDA,IEA)
excitatory synapse  (IDA,IEA,ISO)
external side of plasma membrane  (IDA)
glutamatergic synapse  (IDA,IEA,IMP,ISO)
ionotropic glutamate receptor complex  (IEA,ISO,TAS)
membrane  (IEA,ISO)
neuromuscular junction  (IDA)
neuron projection  (IDA,IEA,ISO)
neuron spine  (IDA,IEA,ISO)
neuronal cell body  (IDA,IEA,ISO)
neuronal cell body membrane  (IDA)
perisynaptic space  (IEA,ISO)
plasma membrane  (IBA,IDA,IEA,ISO,TAS)
postsynapse  (IEA,ISO)
postsynaptic density  (IDA,IEA,ISO)
postsynaptic density membrane  (IBA,IDA,IEA,ISO,ISS)
postsynaptic density, intracellular component  (IDA)
postsynaptic membrane  (IDA,IEA,IEP,ISO,ISS,NAS)
presynapse  (IEA,ISO,ISS)
presynaptic active zone membrane  (IDA,IEA)
presynaptic membrane  (IDA,IEP)
protein-containing complex  (IDA)
proximal dendrite  (IDA)
recycling endosome  (IEA,ISO)
recycling endosome membrane  (IDA,IEA)
Schaffer collateral - CA1 synapse  (NAS)
somatodendritic compartment  (IEA,ISO)
synapse  (IDA,IEA,IMP,ISO)
synaptic membrane  (IDA,IEA,IMP,ISO)
synaptic vesicle  (IEA,ISO)
synaptic vesicle membrane  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Co-localization of AMPA receptor subunits in the nucleus of the solitary tract in the rat. Aicher SA, etal., Brain Res 2002 Dec 27;958(2):454-8.
2. Role of GluR1 expression in nucleus accumbens neurons in cocaine sensitization and cocaine-seeking behavior. Bachtell RK, etal., Eur J Neurosci. 2008 May;27(9):2229-40. doi: 10.1111/j.1460-9568.2008.06199.x. Epub 2008 Apr 22.
3. Control of synaptic strength by glial TNFalpha. Beattie EC, etal., Science. 2002 Mar 22;295(5563):2282-5.
4. Neonatal ethanol exposure reduces AMPA but not NMDA receptor levels in the rat neocortex. Bellinger FP, etal., Brain Res Dev Brain Res. 2002 May 30;136(1):77-84. doi: 10.1016/s0165-3806(02)00363-2.
5. Extinction of morphine-dependent conditioned behavior is associated with increased phosphorylation of the GluR1 subunit of AMPA receptors at hippocampal synapses. Billa SK, etal., Eur J Neurosci. 2009 Jan;29(1):55-64. doi: 10.1111/j.1460-9568.2008.06560.x. Epub 2008 Dec 11.
6. Modification of ionotropic glutamate receptor-mediated processes in the rat hippocampus following repeated, brief seizures. Borbely S, etal., Neuroscience. 2009 Mar 3;159(1):358-68. Epub 2008 Dec 27.
7. Behavioral sensitization to cocaine is associated with increased AMPA receptor surface expression in the nucleus accumbens. Boudreau AC and Wolf ME, J Neurosci. 2005 Oct 5;25(40):9144-51. doi: 10.1523/JNEUROSCI.2252-05.2005.
8. Extinction of Contextual Cocaine Memories Requires Cav1.2 within D1R-Expressing Cells and Recruits Hippocampal Cav1.2-Dependent Signaling Mechanisms. Burgdorf CE, etal., J Neurosci. 2017 Dec 6;37(49):11894-11911. doi: 10.1523/JNEUROSCI.2397-17.2017. Epub 2017 Oct 31.
9. GLYX-13, a NMDA receptor glycine-site functional partial agonist, induces antidepressant-like effects without ketamine-like side effects. Burgdorf J, etal., Neuropsychopharmacology. 2013 Apr;38(5):729-42. doi: 10.1038/npp.2012.246. Epub 2012 Dec 5.
10. Central amygdala GluA1 facilitates associative learning of opioid reward. Cai YQ, etal., J Neurosci. 2013 Jan 23;33(4):1577-88. doi: 10.1523/JNEUROSCI.1749-12.2013.
11. Cocaine-seeking behaviour is differentially expressed in male and female mice exposed to maternal separation and is associated with alterations in AMPA receptors subunits in the medial prefrontal cortex. Castro-Zavala A, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jul 13;109:110262. doi: 10.1016/j.pnpbp.2021.110262. Epub 2021 Jan 23.
12. D1 dopamine receptor stimulation increases GluR1 surface expression in nucleus accumbens neurons. Chao SZ, etal., J Neurochem. 2002 Nov;83(3):704-12. doi: 10.1046/j.1471-4159.2002.01164.x.
13. Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal. Chartoff EH, etal., J Neurosci. 2006 Jun 14;26(24):6450-7. doi: 10.1523/JNEUROSCI.0491-06.2006.
14. A four PDZ domain-containing splice variant form of GRIP1 is localized in GABAergic and glutamatergic synapses in the brain. Charych EI, etal., J Biol Chem. 2004 Sep 10;279(37):38978-90. doi: 10.1074/jbc.M405786200. Epub 2004 Jun 29.
15. Control of excitatory and inhibitory synapse formation by neuroligins. Chih B, etal., Science. 2005 Feb 25;307(5713):1324-8. Epub 2005 Jan 27.
16. Reinforcement-related regulation of AMPA glutamate receptor subunits in the ventral tegmental area enhances motivation for cocaine. Choi KH, etal., J Neurosci. 2011 May 25;31(21):7927-37. doi: 10.1523/JNEUROSCI.6014-10.2011.
17. Involvement of microglial P2X7 receptors and downstream signaling pathways in long-term potentiation of spinal nociceptive responses. Chu YX, etal., Brain Behav Immun. 2010 Oct;24(7):1176-89. Epub 2010 Jun 8.
18. Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex. Colledge M, etal., Neuron. 2000 Jul;27(1):107-19.
19. Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving. Conrad KL, etal., Nature. 2008 Jul 3;454(7200):118-21. doi: 10.1038/nature06995. Epub 2008 May 25.
20. Fast, quantitative in situ hybridization of rare mRNAs using 14C-standards and phosphorus imaging. Cremer CM, etal., J Neurosci Methods. 2009 Dec 15;185(1):56-61. Epub 2009 Sep 15.
21. Alcohol amplifies cingulate cortex signaling and facilitates immobilization-induced hyperalgesia in female rats. Cucinello-Ragland JA, etal., Neurosci Lett. 2021 Sep 14;761:136119. doi: 10.1016/j.neulet.2021.136119. Epub 2021 Jul 17.
22. Increased AMPA receptor GluR1 subunit incorporation in rat hippocampal CA1 synapses during benzodiazepine withdrawal. Das P, etal., J Comp Neurol. 2008 Dec 20;511(6):832-46. doi: 10.1002/cne.21866.
23. PICK1-mediated glutamate receptor subunit 2 (GluR2) trafficking contributes to cell death in oxygen/glucose-deprived hippocampal neurons. Dixon RM, etal., J Biol Chem. 2009 May 22;284(21):14230-5. doi: 10.1074/jbc.M901203200. Epub 2009 Mar 25.
24. Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression. Du J, etal., J Neurosci. 2004 Jul 21;24(29):6578-89.
25. A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. Du J, etal., Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11573-8. doi: 10.1073/pnas.0913138107. Epub 2010 Jun 7.
26. Region-specific tolerance to cocaine-regulated cAMP-dependent protein phosphorylation following chronic self-administration. Edwards S, etal., Eur J Neurosci. 2007 Apr;25(7):2201-13. doi: 10.1111/j.1460-9568.2007.05473.x.
27. Phosphorylation of GluR1, ERK, and CREB during spontaneous withdrawal from chronic heroin self-administration. Edwards S, etal., Synapse. 2009 Mar;63(3):224-35. doi: 10.1002/syn.20601.
28. Striatal H3K27 Acetylation Linked to Glutamatergic Gene Dysregulation in Human Heroin Abusers Holds Promise as Therapeutic Target. Egervari G, etal., Biol Psychiatry. 2017 Apr 1;81(7):585-594. doi: 10.1016/j.biopsych.2016.09.015. Epub 2016 Sep 28.
29. Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors. Essmann CL, etal., Nat Neurosci. 2008 Sep;11(9):1035-43. doi: 10.1038/nn.2171.
30. PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity. Esteban JA, etal., Nat Neurosci. 2003 Feb;6(2):136-43.
31. Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation. Evers DM, etal., Nat Neurosci. 2010 Oct;13(10):1199-207. doi: 10.1038/nn.2624. Epub 2010 Aug 29.
32. Calcium-permeable AMPA receptor activity and GluA1 trafficking in the basolateral amygdala regulate operant alcohol self-administration. Faccidomo S, etal., Addict Biol. 2021 Sep;26(5):e13049. doi: 10.1111/adb.13049. Epub 2021 May 5.
33. Ultrastructural localisation and differential agonist-induced regulation of AMPA and kainate receptors present at the presynaptic active zone and postsynaptic density. Feligioni M, etal., J Neurochem. 2006 Oct;99(2):549-60. Epub 2006 Aug 11.
34. Glutamatergic reinnervation and assembly of glutamatergic synapses in adult rat skeletal muscle occurs at cholinergic endplates. Francolini M, etal., J Neuropathol Exp Neurol. 2009 Oct;68(10):1103-15.
35. Electrical stimulation of the lateral habenula produces enduring inhibitory effect on cocaine seeking behavior. Friedman A, etal., Neuropharmacology. 2010 Jun 22.
36. Early exposure of cultured hippocampal neurons to excitatory amino acids protects from later excitotoxicity. Friedman LK and Segal M, Int J Dev Neurosci. 2010 Apr;28(2):195-205. Epub 2009 Nov 11.
37. A Novel Role for the Endocannabinoid System in Ameliorating Motivation for Alcohol Drinking and Negative Behavioral Affect after Traumatic Brain Injury in Rats. Fucich EA, etal., J Neurotrauma. 2019 Jun;36(11):1847-1855. doi: 10.1089/neu.2018.5854. Epub 2019 Mar 6.
38. Presynaptic localization of an AMPA-type glutamate receptor in corticostriatal and thalamostriatal axon terminals. Fujiyama F, etal., Eur J Neurosci. 2004 Dec;20(12):3322-30. doi: 10.1111/j.1460-9568.2004.03807.x.
39. Viral-like brain inflammation during development causes increased seizure susceptibility in adult rats. Galic MA, etal., Neurobiol Dis. 2009 Nov;36(2):343-51. Epub 2009 Aug 4.
40. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
41. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
42. A single high dose of cocaine induces behavioural sensitization and modifies mRNA encoding GluR1 and GAP-43 in rats. Grignaschi G, etal., Eur J Neurosci. 2004 Nov;20(10):2833-7. doi: 10.1111/j.1460-9568.2004.03712.x.
43. A-Kinase Anchoring Protein 150 (AKAP150) Promotes Cocaine Reinstatement by Increasing AMPA Receptor Transmission in the Accumbens Shell. Guercio LA, etal., Neuropsychopharmacology. 2018 May;43(6):1395-1404. doi: 10.1038/npp.2017.297. Epub 2017 Dec 12.
44. Inactivation of NMDA Receptors in the Ventral Tegmental Area during Cocaine Self-Administration Prevents GluA1 Upregulation but with Paradoxical Increases in Cocaine-Seeking Behavior. Guzman D, etal., J Neurosci. 2018 Jan 17;38(3):575-585. doi: 10.1523/JNEUROSCI.2828-16.2017. Epub 2017 Dec 1.
45. Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability. Hamdan FF, etal., Am J Hum Genet. 2011 Mar 11;88(3):306-16. doi: 10.1016/j.ajhg.2011.02.001. Epub 2011 Mar 3.
46. Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction. Hayashi Y, etal., Science. 2000 Mar 24;287(5461):2262-7. doi: 10.1126/science.287.5461.2262.
47. Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP γ8. Herguedas B, etal., Science. 2019 Apr 26;364(6438):eaav9011. doi: 10.1126/science.aav9011. Epub 2019 Mar 14.
48. Glutamate receptor GluR-K1: structure, function, and expression in the brain. Hollmann M, etal., Cold Spring Harb Symp Quant Biol 1990;55:41-55.
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PMID:18403705   PMID:18815255   PMID:18819923   PMID:18829953   PMID:18957222   PMID:19013221   PMID:19020286   PMID:19073915   PMID:19110036   PMID:19120442   PMID:19238810   PMID:19258522  
PMID:19439609   PMID:19503082   PMID:19563786   PMID:19629758   PMID:19657020   PMID:19773551   PMID:19858198   PMID:19886034   PMID:20051515   PMID:20131911   PMID:20202754   PMID:20417256  
PMID:20418887   PMID:20423831   PMID:20434989   PMID:20463192   PMID:20584904   PMID:20826795   PMID:20869354   PMID:20953906   PMID:20963825   PMID:21080412   PMID:21143596   PMID:21144999  
PMID:21147092   PMID:21170339   PMID:21172611   PMID:21185848   PMID:21220022   PMID:21439793   PMID:21461922   PMID:21498562   PMID:21539895   PMID:21558424   PMID:21564097   PMID:21700703  
PMID:21795692   PMID:21846932   PMID:21876464   PMID:21878564   PMID:21937801   PMID:22108330   PMID:22223644   PMID:22302822   PMID:22373567   PMID:22405206   PMID:22470488   PMID:22567428  
PMID:22632720   PMID:22980744   PMID:23141062   PMID:23160045   PMID:23277581   PMID:23296627   PMID:23303939   PMID:23326329   PMID:23375774   PMID:23392471   PMID:23395379   PMID:23511975  
PMID:23537341   PMID:23545413   PMID:23583340   PMID:23598433   PMID:23676497   PMID:23694703   PMID:23760273   PMID:23884930   PMID:23974710   PMID:24002084   PMID:24023391   PMID:24133208  
PMID:24244357   PMID:24259587   PMID:24442866   PMID:24625397   PMID:24966334   PMID:24983627   PMID:25017011   PMID:25126703   PMID:25225098   PMID:25429150   PMID:25472821   PMID:25524891  
PMID:25533481   PMID:25609091   PMID:25627107   PMID:25697598   PMID:25753037   PMID:25792422   PMID:25796132   PMID:25918374   PMID:25964356   PMID:26049209   PMID:26055072   PMID:26134564  
PMID:26220330   PMID:26260133   PMID:26674878   PMID:26725511   PMID:26773257   PMID:26839312   PMID:27060412   PMID:27118769   PMID:27601647   PMID:27826230   PMID:27965425   PMID:28132827  
PMID:28263869   PMID:28377502   PMID:28474392   PMID:28630296   PMID:28875935   PMID:28916629   PMID:29098531   PMID:29107806   PMID:29383693   PMID:29476059   PMID:29490264   PMID:29592780  
PMID:30328550   PMID:30575928   PMID:30747310   PMID:31146278   PMID:31283924   PMID:31705923   PMID:31721013   PMID:31794026   PMID:32162577   PMID:33022406   PMID:33049318   PMID:33075473  
PMID:33244735   PMID:33393454   PMID:35136046   PMID:35227653   PMID:35820448   PMID:37544581   PMID:37955815   PMID:37993087  


Genomics

Comparative Map Data
Gria1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81041,710,540 - 42,030,105 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1041,711,080 - 42,030,309 (+)EnsemblGRCr8
mRatBN7.21041,210,713 - 41,527,283 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1041,210,713 - 41,527,283 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1045,861,160 - 46,177,214 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01045,351,373 - 45,667,433 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01040,855,030 - 41,171,065 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01042,441,723 - 42,760,200 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1042,614,713 - 42,760,200 (+)Ensemblrn6Rnor6.0
Rnor_5.01042,257,736 - 42,571,220 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41042,613,359 - 42,616,610 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1040,506,762 - 40,822,664 (+)NCBICelera
Cytogenetic Map10q22NCBI
GRIA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385153,489,615 - 153,813,869 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5153,489,615 - 153,813,869 (+)Ensemblhg38GRCh38
GRCh375152,870,230 - 153,193,429 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365152,850,499 - 153,171,354 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345152,850,498 - 153,171,354NCBI
Celera5148,945,616 - 149,268,929 (+)NCBICelera
Cytogenetic Map5q33.2NCBI
HuRef5148,010,721 - 148,334,111 (+)NCBIHuRef
CHM1_15152,302,506 - 152,626,274 (+)NCBICHM1_1
T2T-CHM13v2.05154,022,776 - 154,347,051 (+)NCBIT2T-CHM13v2.0
Gria1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391156,902,342 - 57,221,070 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1156,902,213 - 57,221,070 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381157,011,571 - 57,330,244 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1157,011,387 - 57,330,244 (+)Ensemblmm10GRCm38
MGSCv371156,825,193 - 57,143,746 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361156,855,379 - 57,146,439 (+)NCBIMGSCv36mm8
Celera1161,935,002 - 62,079,468 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1134.51NCBI
Gria1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554087,912,592 - 8,223,570 (+)Ensembl
ChiLan1.0NW_0049554087,912,223 - 8,226,241 (+)NCBIChiLan1.0ChiLan1.0
GRIA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24148,684,899 - 149,011,988 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15146,824,470 - 147,151,533 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05148,879,996 - 149,206,914 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15154,877,807 - 155,204,660 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5154,879,080 - 155,204,660 (+)EnsemblpanPan2panpan1.1
GRIA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1455,801,269 - 56,103,383 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl455,803,296 - 56,103,669 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha455,639,927 - 55,995,772 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0456,183,572 - 56,538,983 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl456,237,177 - 56,538,754 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1456,012,350 - 56,367,654 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0456,111,546 - 56,466,793 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0456,613,928 - 56,969,631 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gria1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213110,488,036 - 110,787,054 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365158,940,009 - 9,083,151 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365158,937,391 - 9,236,438 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1669,332,587 - 69,655,380 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11669,332,786 - 69,654,366 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21675,191,970 - 75,275,696 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRIA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12355,944,128 - 56,265,748 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2356,101,294 - 56,265,849 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603421,402,866 - 21,730,046 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gria1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473335,339,683 - 35,647,349 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473335,337,039 - 35,648,184 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gria1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1940,879,210 - 41,198,259 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gria1
2584 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:52
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000071615, ENSRNOT00000073148
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
D10Rat126  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,482,022 - 41,482,228 (+)MAPPERmRatBN7.2
Rnor_6.01042,716,036 - 42,716,241NCBIRnor6.0
Rnor_5.01042,526,318 - 42,526,523UniSTSRnor5.0
Celera1040,777,431 - 40,777,636UniSTS
RH 3.4 Map10452.9UniSTS
RH 3.4 Map10452.9RGD
RH 2.0 Map10470.1RGD
SHRSP x BN Map1038.6199RGD
FHH x ACI Map1035.9499RGD
D10Rat165  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81041,862,380 - 41,862,599 (+)Marker Load Pipeline
mRatBN7.21041,361,875 - 41,362,094 (+)MAPPERmRatBN7.2
Rnor_6.01042,592,183 - 42,592,397NCBIRnor6.0
Rnor_6.01042,595,412 - 42,595,630NCBIRnor6.0
Rnor_5.01042,408,413 - 42,408,631UniSTSRnor5.0
Celera1040,657,748 - 40,657,974UniSTS
SHRSP x BN Map1038.5499UniSTS
SHRSP x BN Map1038.5499RGD
D10Got68  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,415,826 - 41,416,063 (+)MAPPERmRatBN7.2
Rnor_6.01042,649,802 - 42,650,038NCBIRnor6.0
Rnor_5.01042,460,499 - 42,460,735UniSTSRnor5.0
Celera1040,712,729 - 40,712,953UniSTS
RH 3.4 Map10452.9UniSTS
RH 3.4 Map10452.9RGD
X57497  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,527,211 - 41,527,327 (+)MAPPERmRatBN7.2
Rnor_6.01042,760,129 - 42,760,244NCBIRnor6.0
Rnor_5.01042,571,149 - 42,571,264UniSTSRnor5.0
Celera1040,822,593 - 40,822,708UniSTS
RH138240  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,231,885 - 41,232,036 (+)MAPPERmRatBN7.2
Rnor_6.01042,463,288 - 42,463,438NCBIRnor6.0
Rnor_5.01042,279,301 - 42,279,451UniSTSRnor5.0
RGSC_v3.41042,634,532 - 42,634,682UniSTSRGSC3.4
Celera1040,527,881 - 40,528,031UniSTS
RH 3.4 Map10440.59UniSTS
AU048687  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,239,851 - 41,240,077 (+)MAPPERmRatBN7.2
Rnor_6.01042,471,248 - 42,471,471NCBIRnor6.0
Rnor_5.01042,287,261 - 42,287,484UniSTSRnor5.0
RGSC_v3.41042,642,492 - 42,642,715UniSTSRGSC3.4
Celera1040,535,851 - 40,536,104UniSTS
AU049642  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81041,940,221 - 41,940,378 (+)Marker Load Pipeline
Celera1040,736,495 - 40,736,651UniSTS
RH143108  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,491,538 - 41,491,644 (+)MAPPERmRatBN7.2
Rnor_6.01042,725,552 - 42,725,657NCBIRnor6.0
Rnor_5.01042,535,834 - 42,535,939UniSTSRnor5.0
Celera1040,786,947 - 40,787,052UniSTS
RH 3.4 Map10452.8UniSTS
RH144075  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,527,332 - 41,527,523 (+)MAPPERmRatBN7.2
Rnor_6.01042,760,250 - 42,760,440NCBIRnor6.0
Rnor_5.01042,571,270 - 42,571,460UniSTSRnor5.0
Celera1040,822,714 - 40,822,904UniSTS
RH 3.4 Map10452.7UniSTS
BF416798  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,241,330 - 41,241,420 (+)MAPPERmRatBN7.2
Rnor_6.01042,472,725 - 42,472,814NCBIRnor6.0
Rnor_5.01042,288,738 - 42,288,827UniSTSRnor5.0
RGSC_v3.41042,643,969 - 42,644,058UniSTSRGSC3.4
Celera1040,537,358 - 40,537,447UniSTS
RH 3.4 Map10441.0UniSTS
BF390153  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,218,612 - 41,218,784 (+)MAPPERmRatBN7.2
Rnor_6.01042,449,623 - 42,449,794NCBIRnor6.0
Rnor_5.01042,265,636 - 42,265,807UniSTSRnor5.0
RGSC_v3.41042,621,259 - 42,621,430UniSTSRGSC3.4
Celera1040,514,678 - 40,514,849UniSTS
AU049595  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,261,128 - 41,261,344 (+)MAPPERmRatBN7.2
Rnor_6.01042,492,689 - 42,492,906NCBIRnor6.0
Rnor_5.01042,308,480 - 42,308,697UniSTSRnor5.0
RGSC_v3.41042,663,835 - 42,664,052UniSTSRGSC3.4
Celera1040,556,980 - 40,557,203UniSTS
AU049867  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21041,523,343 - 41,523,566 (+)MAPPERmRatBN7.2
Rnor_6.01042,756,267 - 42,756,489NCBIRnor6.0
Rnor_5.01042,567,294 - 42,567,516UniSTSRnor5.0
Celera1040,818,668 - 40,818,890UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 67 149 60 59 28 49 28 6 249 147 8 126 57 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000071615   ⟹   ENSRNOP00000064722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1041,711,080 - 42,028,708 (+)Ensembl
mRatBN7.2 Ensembl1041,210,713 - 41,527,283 (+)Ensembl
Rnor_6.0 Ensembl1042,618,487 - 42,760,200 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000073148   ⟹   ENSRNOP00000066072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1041,880,723 - 42,028,043 (+)Ensembl
mRatBN7.2 Ensembl1041,380,221 - 41,527,283 (+)Ensembl
Rnor_6.0 Ensembl1042,614,713 - 42,760,129 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081136   ⟹   ENSRNOP00000074119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1041,711,212 - 42,028,043 (+)Ensembl
mRatBN7.2 Ensembl1041,210,713 - 41,527,283 (+)Ensembl
Rnor_6.0 Ensembl1042,614,713 - 42,760,129 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000144558   ⟹   ENSRNOP00000101986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1041,711,080 - 42,030,309 (+)Ensembl
RefSeq Acc Id: NM_031608   ⟹   NP_113796
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81041,711,235 - 42,027,778 (+)NCBI
mRatBN7.21041,210,713 - 41,527,283 (+)NCBI
Rnor_6.01042,441,723 - 42,760,200 (+)NCBI
Rnor_5.01042,257,736 - 42,571,220 (+)NCBI
RGSC_v3.41042,613,359 - 42,616,610 (+)RGD
Celera1040,506,762 - 40,822,664 (+)RGD
Sequence:
RefSeq Acc Id: XM_063269677   ⟹   XP_063125747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81041,710,540 - 42,030,105 (+)NCBI
RefSeq Acc Id: NP_113796   ⟸   NM_031608
- Peptide Label: precursor
- UniProtKB: P19490 (UniProtKB/Swiss-Prot),   A6HEN8 (UniProtKB/TrEMBL),   A0A0G2K798 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066072   ⟸   ENSRNOT00000073148
Ensembl Acc Id: ENSRNOP00000074119   ⟸   ENSRNOT00000081136
Ensembl Acc Id: ENSRNOP00000064722   ⟸   ENSRNOT00000071615
RefSeq Acc Id: XP_063125747   ⟸   XM_063269677
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K798 (UniProtKB/TrEMBL),   A6HEN9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101986   ⟸   ENSRNOT00000144558
Protein Domains
Ionotropic glutamate receptor C-terminal   Ionotropic glutamate receptor L-glutamate and

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19490-F1-model_v2 AlphaFold P19490 1-907 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621531 AgrOrtholog
BioCyc Gene G2FUF-25030 BioCyc
Ensembl Genes ENSRNOG00000045816 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000071615.4 UniProtKB/Swiss-Prot
  ENSRNOT00000081136 ENTREZGENE
  ENSRNOT00000081136.2 UniProtKB/Swiss-Prot
  ENSRNOT00000144558 ENTREZGENE
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  3.40.50.2300 UniProtKB/Swiss-Prot
  Periplasmic binding protein-like II UniProtKB/Swiss-Prot
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot
  Glu/Gly-bd UniProtKB/Swiss-Prot
  Iono_rcpt_met UniProtKB/Swiss-Prot
  Ionotropic_Glu_rcpt UniProtKB/Swiss-Prot
  Iontro_rcpt UniProtKB/Swiss-Prot
  Peripla_BP_I UniProtKB/Swiss-Prot
KEGG Report rno:50592 UniProtKB/Swiss-Prot
NCBI Gene 50592 ENTREZGENE
PANTHER IONOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot
Pfam ANF_receptor UniProtKB/Swiss-Prot
  Lig_chan UniProtKB/Swiss-Prot
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot
PhenoGen Gria1 PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000045816 RatGTEx
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot
  PBPe UniProtKB/Swiss-Prot
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot
  SSF53822 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A0A0G2K798 ENTREZGENE, UniProtKB/TrEMBL
  A6HEN8 ENTREZGENE, UniProtKB/TrEMBL
  A6HEN9 ENTREZGENE, UniProtKB/TrEMBL
  GRIA1_RAT UniProtKB/Swiss-Prot
  M0R5P7_RAT UniProtKB/TrEMBL
  M0R9A7_RAT UniProtKB/TrEMBL
  P19490 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Gria1  glutamate ionotropic receptor AMPA type subunit 1  Gria1  glutamate receptor, ionotropic, AMPA 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-24 Gria1  glutamate receptor, ionotropic, AMPA 1  Gria1  glutamate receptor, ionotropic, AMPA1 (alpha 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Gria1  glutamate receptor, ionotropic, AMPA1 (alpha 1)      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Gria1  glutamate receptor, ionotropic, AMPA1 (alpha 1)      Symbol and Name status set to provisional 70820 PROVISIONAL