RGD Reference Report - Regulation of AMPA receptor trafficking by O-glycosylation. - Rat Genome Database

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Regulation of AMPA receptor trafficking by O-glycosylation.

Authors: Kanno, T  Yaguchi, T  Nagata, T  Mukasa, T  Nishizaki, T 
Citation: Kanno T, etal., Neurochem Res. 2010 May;35(5):782-8. Epub 2010 Feb 18.
RGD ID: 4107350
Pubmed: PMID:20165912   (View Abstract at PubMed)
DOI: DOI:10.1007/s11064-010-0135-1   (Journal Full-text)

The present study investigated the role of O-linked beta-N-acetylglucosamine (O-GlcNAc) glycosylation (O-GlcNAcylation) in AMPA receptor trafficking. Alloxan, an inhibitor of O-GlcNAc transferase, potentiated responses of AMPA receptors composed of the GluR1 subunit expressed in Xenopus oocytes. No potentiating effect of alloxan was obtained with mutant GluR1 (S831A) receptor lacking CaMKII phosphorylation site. Alloxan facilitated basal synaptic transmission to approximately 120% of basal levels and enhanced Schaffer collateral-CA1 long-term potentiation (LTP) in rat hippocampal slices, especially in the late phase of the LTP. Alloxan stimulated translocation of the GluR1 and GluR2 subunit from the cytosol towards the plasma membrane in rat hippocampal slices with the LTP, although it had no effect on subcellular distribution of the NR1 subunit. Taken together, the results of the present study show that alloxan regulates AMPA receptor trafficking by inhibiting O-GlcNAcylation, to modulate hippocampal synaptic transmission and synaptic plasticity.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of membrane potential  IMP 4107350 RGD 
response to toxic substance  IMP 4107350alloxanRGD 

Objects Annotated

Genes (Rattus norvegicus)
Gria1  (glutamate ionotropic receptor AMPA type subunit 1)


Additional Information