RGD Reference Report - Myo-inositol treatment prevents biochemical changes triggered by kainate-induced status epilepticus. - Rat Genome Database

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Myo-inositol treatment prevents biochemical changes triggered by kainate-induced status epilepticus.

Authors: Solomonia, R  Mikautadze, E  Nozadze, M  Kuchiashvili, N  Lepsveridze, E  Kiguradze, T 
Citation: Solomonia R, etal., Neurosci Lett. 2010 Jan 14;468(3):277-81. Epub 2009 Nov 13.
RGD ID: 4107719
Pubmed: PMID:19914343   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neulet.2009.11.012   (Journal Full-text)

Identification of the compounds preventing the biochemical changes underlying the epileptogenesis process is of great importance. We have previously shown that myo-inositol (MI) administration reduces kainic acid (KA) induced seizure scores. MI treatment effects on biochemical changes triggered by KA induced status epilepticus (SE) were investigated in the present study. After SE one group of rats was treated with saline, whereas the second group with MI. Control groups received either saline or MI administration. Changes in the amounts of following proteins were studied in the hippocampus and neocortex of rats: GLUR1 subunit of glutamate receptors, calcium/calmodulin-dependent protein kinase II (CaMKII), and heat shock protein 90. No changes were found 28-30h after experiments. However on 28th day of experiment the amounts of GLUR1 and CaMKII were strongly reduced in the hippocampus of KA treated animals but MI significantly halted this reduction. Obtained results indicate anti-epileptogenic features of MI on biochemical level.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
status epilepticus  ISOGria1 (Rattus norvegicus)4107719; 4107719protein:decreased expression:hippocampus (rat)RGD 
status epilepticus  IEP 4107719protein:decreased expression:hippocampus (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gria1  (glutamate ionotropic receptor AMPA type subunit 1)

Genes (Mus musculus)
Gria1  (glutamate receptor, ionotropic, AMPA1 (alpha 1))

Genes (Homo sapiens)
GRIA1  (glutamate ionotropic receptor AMPA type subunit 1)


Additional Information