RGD Reference Report - Mechanisms of CaMKII action in long-term potentiation. - Rat Genome Database

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Mechanisms of CaMKII action in long-term potentiation.

Authors: Lisman, J  Yasuda, R  Raghavachari, S 
Citation: Lisman J, etal., Nat Rev Neurosci. 2012 Feb 15;13(3):169-82. doi: 10.1038/nrn3192.
RGD ID: 7240704
Pubmed: PMID:22334212   (View Abstract at PubMed)
PMCID: PMC4050655   (View Article at PubMed Central)
DOI: DOI:10.1038/nrn3192   (Journal Full-text)

Long-term potentiation (LTP) of synaptic strength occurs during learning and can last for long periods, making it a probable mechanism for memory storage. LTP induction results in calcium entry, which activates calcium/calmodulin-dependent protein kinase II (CaMKII). CaMKII subsequently translocates to the synapse, where it binds to NMDA-type glutamate receptors and produces potentiation by phosphorylating principal and auxiliary subunits of AMPA-type glutamate receptors. These processes are all localized to stimulated spines and account for the synapse-specificity of LTP. In the later stages of LTP, CaMKII has a structural role in enlarging and strengthening the synapse.

Objects Annotated

Genes (Rattus norvegicus)
Cacng2  (calcium voltage-gated channel auxiliary subunit gamma 2)
Camk2a  (calcium/calmodulin-dependent protein kinase II alpha)
Camk2b  (calcium/calmodulin-dependent protein kinase II beta)
Gria1  (glutamate ionotropic receptor AMPA type subunit 1)
Grin2b  (glutamate ionotropic receptor NMDA type subunit 2B)

Genes (Mus musculus)
Cacng2  (calcium channel, voltage-dependent, gamma subunit 2)
Camk2a  (calcium/calmodulin-dependent protein kinase II alpha)
Camk2b  (calcium/calmodulin-dependent protein kinase II, beta)
Gria1  (glutamate receptor, ionotropic, AMPA1 (alpha 1))
Grin2b  (glutamate receptor, ionotropic, NMDA2B (epsilon 2))

Genes (Homo sapiens)
CACNG2  (calcium voltage-gated channel auxiliary subunit gamma 2)
CAMK2A  (calcium/calmodulin dependent protein kinase II alpha)
CAMK2B  (calcium/calmodulin dependent protein kinase II beta)
GRIA1  (glutamate ionotropic receptor AMPA type subunit 1)
GRIN2B  (glutamate ionotropic receptor NMDA type subunit 2B)


Additional Information