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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621531
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gria1
Name: glutamate ionotropic receptor AMPA type subunit 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gria1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of GRIA1 mRNA; bisphenol A results in decreased expression of GRIA1 proteinPMID:24820113 PMID:30312744 PMID:30816183 PMID:32528016
Gria1increases methylationEXP 6480464CTDbisphenol A results in increased methylation of GRIA1 genePMID:28505145
Gria1multiple interactionsEXP 6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of GRIA1 mRNA; bisphenol A results in decreased expression of and results in decreased phosphorylation of GRIA1 proteinPMID:32380187 PMID:36041667
Gria1affects methylationISOGRIA1 (Homo sapiens)6480464CTDbisphenol A affects the methylation of GRIA1 genePMID:31601247
Gria1decreases expressionISOGria1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of GRIA1 mRNA; bisphenol A results in decreased expression of GRIA1 proteinPMID:23240141 PMID:23490186 PMID:23523742 PMID:32156529 PMID:36656826
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