RGD Reference Report - Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5. - Rat Genome Database

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Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5.

Authors: Soto, D  Coombs, ID  Renzi, M  Zonouzi, M  Farrant, M  Cull-Candy, SG 
Citation: Soto D, etal., Nat Neurosci. 2009 Mar;12(3):277-85. doi: 10.1038/nn.2266. Epub 2009 Feb 22.
RGD ID: 8554069
Pubmed: PMID:19234459   (View Abstract at PubMed)
PMCID: PMC2735763   (View Article at PubMed Central)
DOI: DOI:10.1038/nn.2266   (Journal Full-text)

Although the properties and trafficking of AMPA-type glutamate receptors (AMPARs) depend critically on associated transmembrane AMPAR regulatory proteins (TARPs) such as stargazin (gamma-2), no TARP has been described that can specifically regulate the important class of calcium-permeable (CP-) AMPARs. We examined the stargazin-related protein gamma-5, which is highly expressed in Bergmann glia, a cell type possessing only CP-AMPARs. gamma-5 was previously thought not to be a TARP, and it has been widely used as a negative control. Here we find that, contrary to expectation, gamma-5 acts as a TARP and serves this role in Bergmann glia. Whereas gamma-5 interacts with all AMPAR subunits, and modifies their behavior to varying extents, its main effect is to regulate the function of AMPAR subunit combinations that lack short-form subunits, which constitute predominantly CP-AMPARs. Our results suggest an important role for gamma-5 in regulating the functional contribution of CP-AMPARs.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Cacng5  (calcium voltage-gated channel auxiliary subunit gamma 5)
Gria1  (glutamate ionotropic receptor AMPA type subunit 1)
Gria2  (glutamate ionotropic receptor AMPA type subunit 2)
Gria4  (glutamate ionotropic receptor AMPA type subunit 4)

Objects referenced in this article
Gene Cacng2 calcium voltage-gated channel auxiliary subunit gamma 2 Rattus norvegicus
Gene Cacng3 calcium voltage-gated channel auxiliary subunit gamma 3 Rattus norvegicus
Gene Cacng4 calcium voltage-gated channel auxiliary subunit gamma 4 Rattus norvegicus
Gene Cacng7 calcium voltage-gated channel auxiliary subunit gamma 7 Rattus norvegicus
Gene Cacng8 calcium voltage-gated channel auxiliary subunit gamma 8 Rattus norvegicus

Additional Information