Gene:	Prkca ( Rattus norvegicus ) protein kinase C, alpha
Description:	displays Ca+2 dependent protein kinase activity
Synonyms:	Pkca;
ArrayIDs:	X07286cds_s_at; 1372176_at;  (details...)
Gene Type:	protein-coding
Additional Data
Candidate gene for:	Eau3 - Experimental allergic uveoretinitis QTL 3 Pia10 - Pristane induced arthritis QTL 10 Cia5 - Collagen induced arthritis QTL 5
primer pair:	635214
Homologs
Homo sapiens: PRKCA     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Prkca     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Prkca RH 3.4 10 1035.79     Rat Celera Assembly 10 91557203 - 91951817     RGSC genome assembly v3.4 10 97366773 - 97625118     Cytogenetic 10 q32.1     genome assembly 3.1 10 97382023 - 97632491 Mus musculus Prkca Mouse genome assembly build 36.1 11 107799562 - 108205242     Cytogenetic 11 11 E1 Homo sapiens PRKCA human genome assembly 17 61729387 - 62237324     Human genome assembly build 36.2 17 61729388 - 62237324     Cytogenetic 17 q22-q23.2   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology zinc ion binding,  nucleotide binding,  protein serine/threonine kinase activity ...  (details...)
Biological Process	Gene Ontology negative regulation of glucose import,  negative regulation of translation,  peptidyl-threonine phosphorylation ...  (details...)
Cellular Component	Gene Ontology protein complex,  nucleus,  mitochondrion ...  (details...)
Disease	Ontology Brain Ischemia,  Hypertrophy, Left Ventricular,  Ovarian Neoplasms ...  (details...)
Expression	Note Reference expressed in adult ventricular myocytes 731217
Pathway	Note Reference activation by the digitalis drug ouabain is linked to Na+/K+-ATPase through Src/EGFR, and is required for the activation of ERK1/2 628493 Ontology vascular endothelial growth factor signaling pathway,  insulin signaling pathway (details...)
Regulation	Note Reference administration of the digitalis drug ouabain with intact cardiac myocytes causes rapid translocation/activation from the soluble to the particulate pools of enzymes 628493
External Links
Databases	DATABASE ID SOURCE SMART: S_TKc IPI SMART: S_TK_X IPI SMART: C2 IPI SMART: C1 IPI PROSITE: ZF_DAG_PE_2 IPI PROSITE: ZF_DAG_PE_1 IPI PROSITE: PROTEIN_KINASE_ST IPI PROSITE: PROTEIN_KINASE_DOM IPI PROSITE: PROTEIN_KINASE_ATP IPI PROSITE: C2 IPI PROSITE: AGC_KINASE_CTER IPI UNIPARC: UPI000157E8AD IPI UNIPARC: UPI000012DF65 IPI KEGG Report: rno:24680 ENTREZGENE HomoloGene Group ID: 55679 ENTREZGENE Germonline: 3395 Pfam: Pkinase_C IPI Pfam: Pkinase IPI Pfam: C2 IPI Pfam: C1_1 IPI KEGG Pathway: 04310 ENTREZGENE KEGG Pathway: 04270 ENTREZGENE KEGG Pathway: 04370 ENTREZGENE KEGG Pathway: 04530 ENTREZGENE KEGG Pathway: 04070 ENTREZGENE KEGG Pathway: 05200 ENTREZGENE KEGG Pathway: 04916 ENTREZGENE KEGG Pathway: 04010 ENTREZGENE KEGG Pathway: 05223 ENTREZGENE KEGG Pathway: 04650 ENTREZGENE KEGG Pathway: 04720 ENTREZGENE KEGG Pathway: 04730 ENTREZGENE KEGG Pathway: 04670 ENTREZGENE KEGG Pathway: 04912 ENTREZGENE KEGG Pathway: 05214 ENTREZGENE KEGG Pathway: 04540 ENTREZGENE KEGG Pathway: 04510 ENTREZGENE KEGG Pathway: 04666 ENTREZGENE KEGG Pathway: 04664 ENTREZGENE KEGG Pathway: 04012 ENTREZGENE KEGG Pathway: 04020 ENTREZGENE InterPro: C2_Ca/lipid-bd_reg_CaLB. IPI InterPro: C2_Ca-dep. IPI InterPro: Ser/Thr_prot_kinase_dom. IPI InterPro: Ser/Thr_prot_kinase_AS. IPI InterPro: Se/Thr_prot_kinase-like_dom. IPI InterPro: Protein_kinase_C_a/b/g. IPI InterPro: Protein_kinase_ATP_BS. IPI InterPro: Prot_kinase_cat_dom. IPI InterPro: Prot_Kinase_C-like_PE/DAG_bd. IPI InterPro: Pkinase_C. IPI InterPro: PKC. IPI InterPro: Kinase-like_dom. IPI InterPro: DAG/PE_bd. IPI InterPro: C2_region. IPI InterPro: C2_membr_targeting. IPI InterPro: AGC-kinase_C. IPI Ensembl Protein: ENSRNOP00000051949 IPI Ensembl Protein: ENSRNOP00000004699 IPI IPI: IPI00766874 IPI IPI: IPI00201792 IPI Entrez Gene: Prkca ENTREZGENE PIRSF: PKC_alpha IPI Ensembl Genes: ENSRNOG00000003491 IPI UniProt: B5DFC4_RAT IPI UniProt: KPCA_RAT IPI RatMap: 34325 ENTREZGENE Superfamily-SCOP: Kinase_like IPI Superfamily-SCOP: C2_CaLB IPI PANTHER: PKC IPI PRINTS: DAGPEDOMAIN. IPI PRINTS: C2DOMAIN. IPI
Sequences	Nucleotide: NM_001105713 Get FASTA Search GEO Profiles Nucleotide: BC169007 Get FASTA Search GEO Profiles Nucleotide: CH473948 Get FASTA Search GEO Profiles Nucleotide: X07286 Get FASTA Search GEO Profiles Nucleotide: XM_001081588 Get FASTA Search GEO Profiles Nucleotide: XM_343975 Get FASTA Search GEO Profiles (View all 6 Nucleotide Accessions) Protein: P05696 Get FASTA Protein: CAA30266 Get FASTA Protein: AAI69007 Get FASTA Protein: EDM06446 Get FASTA Protein: NP_001099183 Get FASTA Protein: XP_001081588 Get FASTA Protein: XP_343976 Get FASTA (View all 7 Protein Accessions)
Clusters	UniGene: 207908
References
Curated References	55 references in RGD related to Prkca
Other References	132 other references at PubMed related to Prkca
Database Information
RGD ID	3395
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-JUN-02: Prkca Protein kinase C, alpha APPROVED Symbol and Name status set to approved 70586