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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3395 Species: Rattus norvegicus RGD Object: Gene Symbol: Prkca Name: protein kinase C, alpha

Acc ID: CHEBI:16469 Term: 17beta-estradiol Definition: The 17beta-isomer of estradiol. CasRN: 50-28-2 Chemical ID: MESH:D004958

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:737062	6480464	CTD	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PRKCA mRNA	PMID:19619570
increases expression	ISO	RGD:737062	6480464	CTD	Estradiol results in increased expression of PRKCA mRNA	PMID:19619570
decreases activity	ISO	RGD:737062	6480464	CTD	Estradiol results in decreased activity of PRKCA protein	PMID:8946564