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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3395
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkca
Name: protein kinase C, alpha
Acc ID: CHEBI:30146
Term: lithium hydride
Definition: An alkali metal hydride where the metal is specified as lithium.
Chemical ID: MESH:D008094
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkcadecreases response to substanceISOPrkca (Mus musculus)6480464CTDPRKCA gene mutant form results in decreased susceptibility to LithiumPMID:25006961
Prkcaincreases response to substanceISOPrkca (Mus musculus)6480464CTDPRKCA gene results in increased susceptibility to LithiumPMID:25006961
Prkcamultiple interactionsISOPrkca (Mus musculus)6480464CTDPRKCA gene mutant form inhibits the reaction [Lithium results in decreased expression of AQP2 protein]; PRKCA gene mutant form inhibits the reaction [Lithium results in decreased expression of SLC14A2 protein]PMID:25006961
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