RGD Reference Report - Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. - Rat Genome Database

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Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition.

Authors: Holmes, K  Roberts, OL  Thomas, AM  Cross, MJ 
Citation: Holmes K, etal., Cell Signal. 2007 Oct;19(10):2003-12. Epub 2007 Jun 12.
RGD ID: 2298729
Pubmed: PMID:17658244   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cellsig.2007.05.013   (Journal Full-text)

Vascular endothelial growth factors (VEGFs) regulate vascular development, angiogenesis and lymphangiogenesis by binding to a number of receptors. VEGFR-1 is required for the recruitment of haematopoietic stem cells and the migration of monocytes and macrophages, VEGFR-2 regulates vascular endothelial function and VEGFR-3 regulates lymphatic endothelial cell function. Over the last decade, considerable progress has been made in delineating the VEGFR-2 specific intracellular signalling cascades leading to proliferation, migration, survival and increased permeability, each of which contributes to the angiogenic response. Furthermore, therapeutic inhibition of VEGFR-2 action is now having an impact in the clinic for the treatment of a number of diseases.

Objects Annotated

Genes (Rattus norvegicus)
Fyn  (FYN proto-oncogene, Src family tyrosine kinase)
Kdr  (kinase insert domain receptor)
Nck1  (NCK adaptor protein 1)
Plcg1  (phospholipase C, gamma 1)
Prkca  (protein kinase C, alpha)
Prkcb  (protein kinase C, beta)
Prkcz  (protein kinase C, zeta)
Ptk2  (protein tyrosine kinase 2)
Sh2d2a  (SH2 domain containing 2A)

Genes (Mus musculus)
Fyn  (Fyn proto-oncogene)
Kdr  (kinase insert domain protein receptor)
Nck1  (non-catalytic region of tyrosine kinase adaptor protein 1)
Plcg1  (phospholipase C, gamma 1)
Prkca  (protein kinase C, alpha)
Prkcb  (protein kinase C, beta)
Prkcz  (protein kinase C, zeta)
Ptk2  (PTK2 protein tyrosine kinase 2)
Sh2d2a  (SH2 domain containing 2A)
Shb  (src homology 2 domain-containing transforming protein B)

Genes (Homo sapiens)
FYN  (FYN proto-oncogene, Src family tyrosine kinase)
KDR  (kinase insert domain receptor)
NCK1  (NCK adaptor protein 1)
PLCG1  (phospholipase C gamma 1)
PRKCA  (protein kinase C alpha)
PRKCB  (protein kinase C beta)
PRKCZ  (protein kinase C zeta)
PTK2  (protein tyrosine kinase 2)
SH2D2A  (SH2 domain containing 2A)
SHB  (SH2 domain containing adaptor protein B)


Additional Information