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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3395
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkca
Name: protein kinase C, alpha
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkcadecreases expressionISOPRKCA (Homo sapiens)6480464CTDCisplatin results in decreased expression of PRKCA mRNAPMID:19561079 PMID:25450742 PMID:27392435
Prkcamultiple interactionsISOPRKCA (Homo sapiens)6480464CTD[[PRKCA protein results in increased phosphorylation of GSTP1 protein] which results in increased metabolism of Cisplatin] which results in decreased susceptibility to Cisplatin; [PRKCA protein results in increased phosphorylation of GSTP1 protein] which results in increased metabolism of Cisplatin; Cisplatin promotes the reaction [jinfukang results in decreased expression of PRKCA mRNA]; jinfukang promotes the reaction [Cisplatin results in decreased expression of PRKCA mRNA]PMID:20654585 PMID:27392435
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