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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3395 Species: Rattus norvegicus RGD Object: Gene Symbol: Prkca Name: protein kinase C, alpha

Acc ID: CHEBI:27958 Term: cocaine Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca. CasRN: 50-36-2 Chemical ID: MESH:D003042

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	EXP		6480464	CTD	Cocaine results in increased expression of PRKCA protein	PMID:12808488
multiple interactions	ISO	RGD:737063	6480464	CTD	FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of PRKCA mRNA]	PMID:18355967
decreases expression	ISO	RGD:737063	6480464	CTD	Cocaine results in decreased expression of PRKCA mRNA	PMID:18355967