A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID:
MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]; calphostin C inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]; Tetradecanoylphorbol Acetate affects the localization of and results in increased activity of PRKCA protein; Tetradecanoylphorbol Acetate inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased phosphorylation of PRKCA protein]
[Ethanol results in increased localization of and results in increased activity of PRKCA protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides]; [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein] which results in increased expression of SOD2; artenimol inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]; artenimol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCA protein]; calphostin C inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein]; Luteolin analog inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCA protein]; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]; piperine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and affects the localization of PRKCA protein]; PRKCA protein affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 mRNA]; Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of and results in increased phosphorylation of and results in increased activity of PRKCA protein]; Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCA protein]; Rosiglitazone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]; Tetradecanoylphorbol Acetate affects the localization of and results in increased activity of PRKCA protein; Tetradecanoylphorbol Acetate results in increased activity of and affects the localization of PRKCA protein; Tetradecanoylphorbol Acetate results in increased localization of and results in increased phosphorylation of and results in increased activity of PRKCA protein; Tetradecanoylphorbol Acetate results in increased phosphorylation of and affects the localization of PRKCA protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein]; bicyclol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PRKCA mRNA]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein]; calphostin C inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]; Egtazic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein]; PRKCA protein promotes the reaction [[Tetradecanoylphorbol Acetate results in increased expression of and results in increased phosphorylation of STAR protein] which results in increased abundance of Progesterone]; PRKCA protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAR mRNA]; PRKCA protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAR protein]; Tetradecanoylphorbol Acetate binds to and affects the localization of PRKCA protein; Tetradecanoylphorbol Acetate results in increased activity of and results in increased localization of PRKCA protein; Tetradecanoylphorbol Acetate results in increased expression of and results in increased phosphorylation of PRKCA protein; TGFB1 affects the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein]; TGFB1 promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein]
