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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3395
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkca
Name: protein kinase C, alpha
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkcadecreases activityISOPRKCA (Homo sapiens)6480464CTDresveratrol results in decreased activity of PRKCA proteinPMID:11709203
Prkcadecreases expressionISOPrkca (Mus musculus)6480464CTDresveratrol results in decreased expression of PRKCA proteinPMID:25505154
Prkcamultiple interactionsISOPRKCA (Homo sapiens)6480464CTDPRKCA protein affects the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein]]; PRKCA protein affects the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein]]; PRKCA protein affects the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]]; resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of and results in increased phosphorylation of and results in increased activity of PRKCA protein]; resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCA protein]PMID:14739659 PMID:15542774 PMID:24672638
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