Gene:	Ins2 ( Rattus norvegicus ) insulin 2
Description:	homolog of human insulin; associated with diabetes mellitus
ArrayIDs:	J04807mRNA_f_at; 1370077_at; E00001cds_f_at; E00001cds_i_at; A_44_P1004376; 6300823; rc_AI014020_f_at; rc_C07167_f_at; 6147695; J04807mRNA_i_at; M25584_at; 6268359;  (details...)
Gene Type:	protein-coding
Additional Data
Candidate gene for:	Iddm25 - Insulin dependent diabetes mellitus QTL 25 Hcar4 - Hepatocarcinoma resistance QTL 4
Homologs
Homo sapiens: INS     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Ins2     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Ins2 genome assembly 3.1 1 203123613 - 203124445     Rat Celera Assembly 1 195461369 - 195462200     RGSC genome assembly v3.4 1 202935548 - 202936379     Cytogenetic 1 q41 Mus musculus Ins2 Mouse genome assembly build 36.1 7 149864566 - 149865613     Cytogenetic 7 7 F5 Homo sapiens INS human genome assembly 11 2137584 - 2139000     Human genome assembly build 36.2 11 2137585 - 2139000     Cytogenetic 11 p15.5   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology hormone activity,  protein binding,  protein complex binding ...  (details...)
Biological Process	Gene Ontology wound healing,  positive regulation of protein kinase B signaling cascade,  positive regulation of phosphoinositide 3-kinase cascade ...  (details...)
Cellular Component	Gene Ontology nucleus,  extracellular space,  extracellular region ...  (details...)
Disease	Ontology Diabetes Mellitus,  Insulin Resistance,  Obesity ...  (details...)
Pathway	Ontology altered insulin signaling pathway,  type 2 diabetes mellitus pathway,  insulin signaling pathway ...  (details...)
Transcript structure	Note Reference contains two introns 729274
External Links
Databases	DATABASE ID SOURCE SMART: IlGF IPI PROSITE: INSULIN IPI UNIPARC: UPI000012D6A1 IPI KEGG Report: rno:24506 ENTREZGENE HomoloGene Group ID: 173 ENTREZGENE Germonline: 2916 Pfam: Insulin IPI KEGG Pathway: 04150 ENTREZGENE KEGG Pathway: 04910 ENTREZGENE KEGG Pathway: 04950 ENTREZGENE KEGG Pathway: 05215 ENTREZGENE KEGG Pathway: 04810 ENTREZGENE KEGG Pathway: 04140 ENTREZGENE KEGG Pathway: 04940 ENTREZGENE KEGG Pathway: 04930 ENTREZGENE InterPro: Insulin-like. IPI InterPro: Ins/IGF/relaxin. IPI IPI: IPI00212593 IPI Ensembl Protein: ENSRNOP00000027656 IPI Gene3D-CATH: Ins/IGF/relaxin IPI Entrez Gene: Ins2 ENTREZGENE UniProt: INS2_RAT IPI Ensembl Genes: ENSRNOG00000020405 IPI RatMap: 34115 ENTREZGENE Superfamily-SCOP: Insulin-like IPI PRINTS: INSULINB. IPI
Sequences	Nucleotide: J00748 Get FASTA Search GEO Profiles Nucleotide: CH473953 Get FASTA Search GEO Profiles Nucleotide: M25583 Get FASTA Search GEO Profiles Nucleotide: AC098563 Get FASTA Search GEO Profiles Nucleotide: M25585 Get FASTA Search GEO Profiles Nucleotide: V01243 Get FASTA Search GEO Profiles Nucleotide: NM_019130 Get FASTA Search GEO Profiles (View all 7 Nucleotide Accessions) Protein: EDM12162 Get FASTA Protein: CAA24560 Get FASTA Protein: NP_062003 Get FASTA Protein: P01323 Get FASTA Protein: AAA41443 Get FASTA Protein: AAA41440 Get FASTA (View all 6 Protein Accessions)
Clusters	UniGene: 989
References
Curated References	27 references in RGD related to Ins2
Other References	13 other references at PubMed related to Ins2
Database Information
RGD ID	2916
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 06-NOV-02: Ins2 insulin 2 Insulin 2 APPROVED Name updated 625702 10-JUN-02: Ins2 Insulin 2 APPROVED Symbol and Name status set to approved 70586