Ins2 (insulin 2) - Rat Genome Database

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Gene: Ins2 (insulin 2) Rattus norvegicus
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Symbol: Ins2
Name: insulin 2
RGD ID: 2916
Description: Predicted to enable several functions, including identical protein binding activity; signaling receptor binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including positive regulation of signal transduction; regulation of primary metabolic process; and regulation of respiratory burst. Predicted to act upstream of with a positive effect on receptor internalization. Predicted to act upstream of or within several processes, including intracellular signal transduction; positive regulation of intracellular signal transduction; and regulation of primary metabolic process. Located in extracellular space and secretory granule. Used to study hypertension. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to human INS (insulin); PARTICIPATES IN altered insulin signaling pathway; forkhead class A signaling pathway; gliclazide pharmacodynamics pathway; INTERACTS WITH (S)-nicotine; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-peptide; CP-II; insulin-2; LOC102549619; uncharacterized LOC102549619
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Hcar4 Iddm25
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81207,272,738 - 207,421,998 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1207,272,742 - 207,273,805 (-)EnsemblGRCr8
mRatBN7.21197,843,277 - 197,992,522 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1197,843,281 - 197,864,775 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1206,216,147 - 206,217,214 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,302,063 - 213,303,130 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01205,976,222 - 205,977,289 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01215,856,967 - 215,858,034 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,856,971 - 215,858,034 (-)Ensemblrn6Rnor6.0
Rnor_5.01222,751,786 - 222,756,821 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41202,935,548 - 202,936,379 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1195,461,309 - 195,462,376 (-)NCBICelera
RGSC_v3.11203,123,613 - 203,124,445 (-)NCBI
Cytogenetic Map1q41NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
adenoma  (ISO)
Albuminuria  (ISO)
Alzheimer's disease  (IEP,ISO)
bipolar disorder  (ISO)
bladder disease  (ISO)
cardiac arrest  (ISO)
cholangiocarcinoma  (ISO)
cognitive disorder  (ISO)
congestive heart failure  (ISO)
cystic kidney disease  (ISO)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (ISO)
diabetic ketoacidosis  (ISO)
Diabetic Nephropathies  (IDA,ISO)
diabetic retinopathy  (ISO)
disease of metabolism  (ISO)
Edema  (ISO)
Experimental Liver Cirrhosis  (ISO)
gestational diabetes  (ISO)
glucose intolerance  (ISO)
hepatitis  (ISO)
hepatocellular carcinoma  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
Hyperkalemia  (ISO)
Hyperproinsulinemia  (ISO)
hypertension  (IDA,ISO)
Hypertriglyceridemia  (ISO)
hypertrophic cardiomyopathy  (ISO)
hyperuricemia  (ISO)
hypoglycemia  (ISO)
hypokalemia  (ISO)
Hypotension  (ISO)
Insulin Resistance  (ISO)
insulinoma  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
left ventricular failure  (ISO)
Lewy body dementia  (ISO)
liver disease  (ISO)
maturity-onset diabetes of the young  (ISO,ISS)
maturity-onset diabetes of the young type 1  (ISO)
maturity-onset diabetes of the young type 10  (ISO)
Memory Disorders  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
MPTP Poisoning  (ISO)
muscular disease  (ISO)
neonatal diabetes mellitus  (ISS)
Neoplasm Invasiveness  (ISO)
neural tube defect  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (ISO)
panic disorder  (ISO)
Paralysis  (ISO)
Paresthesia  (ISO)
Parkinson's disease  (ISO)
permanent neonatal diabetes mellitus  (ISO,ISS)
Permanent Neonatal Diabetes Mellitus 4  (ISO)
Phelan-McDermid syndrome  (ISO)
polycystic ovary syndrome  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
Rhabdomyolysis  (ISO)
steatotic liver disease  (ISO)
Tachycardia  (ISO)
transient neonatal diabetes mellitus  (ISO)
type 1 diabetes mellitus  (ISO,ISS)
type 1 diabetes mellitus 2  (ISO)
type 2 diabetes mellitus  (ISO,ISS)
Type 2 Diabetes Mellitus 1  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Outflow Obstruction  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pronuciferine  (ISO)
(R)-adrenaline  (ISO)
(R)-lipoic acid  (ISO)
(S)-nicotine  (EXP)
1-Oleoyl-2-acetyl-sn-glycerol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-arachidonoylglycerol  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-aminobenzamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-iodotubercidin  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
5-oxo-L-proline  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-Hydroxychlorzoxazone  (ISO)
9-cis-retinoic acid  (ISO)
AACOCF3  (ISO)
acetaminophen O-beta-D-glucosiduronic acid  (ISO)
acetic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
albuterol  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
allethrin  (ISO)
amino acid  (ISO)
amiodarone  (ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
arachidonic acid  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atenolol  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
bafilomycin A1  (EXP)
baicalein  (ISO)
Bardoxolone methyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
berberine  (EXP)
beta-D-glucosamine  (ISO)
bexarotene  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bismuth atom  (ISO)
bismuthane  (ISO)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
boric acid  (ISO)
bromochloroacetic acid  (ISO)
bromocriptine  (ISO)
butan-1-amine  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcidiol  (ISO)
cannabidiolic acid  (ISO)
cannabigerol  (ISO)
cannabigerolic acid  (ISO)
capsaicin  (EXP)
capsazepine  (EXP)
carbamic acid  (ISO)
carvedilol  (ISO)
chlorpropamide  (ISO)
chlorpyrifos  (EXP)
chlorzoxazone  (ISO)
cholesterol  (ISO)
chromium atom  (EXP)
chromium(3+) trichloride  (ISO)
ciprofibrate  (EXP)
clofibrate  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clozapine  (ISO)
co-trimoxazole  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
corticotropin  (ISO)
cortisol  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyproterone acetate  (ISO)
D-glucose  (EXP,ISO)
D-mannopyranose  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
demethoxycurcumin  (ISO)
desmosterol  (ISO)
dexamethasone  (EXP,ISO)
dexamethasone phosphate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diazoxide  (ISO)
dibenziodolium  (ISO)
dicamba  (ISO)
Didymin  (ISO)
diethyl maleate  (ISO)
diethyl sulfate  (ISO)
diethylstilbestrol  (ISO)
digoxin  (EXP,ISO)
dimercaprol  (EXP)
diphosphoric acid  (ISO)
disodium selenite  (ISO)
dopamine  (ISO)
elemental selenium  (ISO)
enalaprilat dihydrate  (ISO)
equilin  (ISO)
ethanol  (ISO)
ethyl dihydrogen phosphate  (ISO)
ethylamine  (ISO)
farnesol  (ISO)
fenofibrate  (ISO)
fentin hydroxide  (ISO)
ferric ammonium citrate  (ISO)
fipronil  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
furan  (EXP)
gatifloxacin  (EXP)
gemcitabine  (ISO)
genistein  (ISO)
Gingerenone A  (EXP,ISO)
glimepiride  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glyburide  (EXP,ISO)
glycerol 2-phosphate  (ISO)
glycine  (ISO)
glycogen  (ISO)
glyoxylic acid  (ISO)
glyphosate  (ISO)
GSK2656157  (EXP)
GW 7647  (ISO)
harmine  (ISO)
hemin  (EXP)
heptadecanoic acid  (ISO)
hexadecanoic acid  (EXP,ISO)
hispidulin  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP,ISO)
inositol  (ISO)
isoflavones  (EXP)
isoprenaline  (EXP)
isopropyl palmitate  (ISO)
kynurenic acid  (ISO)
L-ascorbic acid  (ISO)
L-cystathionine  (ISO)
lanthanum atom  (ISO)
lercanidipine  (ISO)
Licarin A  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lovastatin  (EXP)
LY294002  (ISO)
magnesium atom  (ISO)
magnesium oxide  (ISO)
Magnolol  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
Melengestrol acetate  (ISO)
mercaptopurine  (EXP)
metformin  (ISO)
methadone  (ISO)
methotrexate  (ISO)
methyl dihydrogen phosphate  (ISO)
methylarsonite  (ISO)
methylglyoxal  (EXP)
metoclopramide  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
miquelianin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
Moxonidine  (EXP,ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methylnicotinate  (ISO)
N-Phenylmaleimide  (ISO)
nateglinide  (ISO)
neomycin  (EXP)
nicotinamide  (ISO)
nicotine  (EXP)
nitric oxide  (ISO)
norethisterone  (ISO)
norgestrel  (ISO)
norwogonin  (ISO)
NS-398  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
octocrylene  (ISO)
octreotide  (EXP,ISO)
olanzapine  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oltipraz  (ISO)
orlistat  (ISO)
orotic acid  (ISO)
oxybenzone  (ISO)
palmitoleic acid  (ISO)
paracetamol  (ISO)
paroxetine  (EXP)
Pentagastrin  (ISO)
pentolinium tartrate  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP)
phenylarsine oxide  (EXP)
phenylarsonous acid  (ISO)
PhIP  (ISO)
phloretin  (ISO)
phosphoric acid  (ISO)
pioglitazone  (ISO)
potassium chloride  (ISO)
prallethrin  (ISO)
prednisone  (ISO)
progesterone  (EXP)
propranolol  (ISO)
Ptaquiloside  (ISO)
purine-6-thiol  (EXP)
pyridine  (EXP)
pyruvic acid  (EXP)
quercetin  (EXP,ISO)
quinoxyfen  (ISO)
rac-lactic acid  (ISO)
RES-701-1  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rimonabant  (ISO)
risperidone  (ISO)
ritodrine  (ISO)
Ro 41-5253  (ISO)
rosmarinic acid  (ISO)
Rutamarin  (ISO)
ruthenium red  (EXP)
saquinavir  (ISO)
saroglitazar  (ISO)
SB 203580  (EXP,ISO)
sebacic acid  (ISO)
selenium atom  (ISO)
sertraline  (EXP)
sirolimus  (ISO)
SKF-96365 hydrochloride  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
Sodium oleate  (ISO)
Sodium salicylate  (ISO)
spironolactone  (ISO)
staurosporine  (EXP)
streptozocin  (EXP,ISO)
sucrose  (ISO)
sulforaphane  (ISO)
sulpiride  (ISO)
tacrolimus hydrate  (ISO)
tauroursodeoxycholic acid  (ISO)
telmisartan  (ISO)
terbutaline  (ISO)
testosterone  (EXP,ISO)
thapsigargin  (ISO)
Thiocarbohydrazide  (ISO)
tolbutamide  (ISO)
tolylfluanid  (ISO)
triamcinolone  (ISO)
tributylstannane  (ISO)
triciribine  (ISO)
triclosan  (EXP)
triflumizole  (ISO)
trimethyltin  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (EXP,ISO)
undecane  (ISO)
valproic acid  (ISO)
vandetanib  (ISO)
vanillic acid  (ISO)
vitamin D  (ISO)
wogonin  (ISO)
wortmannin  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (ISO)
alpha-beta T cell activation  (ISO)
biological_process  (ND)
ER overload response  (ISO)
fatty acid homeostasis  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
glucose homeostasis  (IBA,ISO)
glucose metabolic process  (IEA,ISO)
glycoprotein biosynthetic process  (ISO)
insulin processing  (IEA,ISO)
insulin receptor signaling pathway  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
lactate biosynthetic process  (ISO)
lipid biosynthetic process  (ISO)
lipid catabolic process  (ISO)
lipoprotein biosynthetic process  (ISO)
myoblast fusion  (ISO)
myotube differentiation  (ISO)
negative regulation of acute inflammatory response  (ISO)
negative regulation of fatty acid metabolic process  (ISO)
negative regulation of feeding behavior  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of gluconeogenesis  (ISO)
negative regulation of glycogen catabolic process  (ISO)
negative regulation of lipid catabolic process  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of protein secretion  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of respiratory burst involved in inflammatory response  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuron projection maintenance  (ISO)
nitric oxide-cGMP-mediated signaling  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of D-glucose import across plasma membrane  (ISO)
positive regulation of dendritic spine maintenance  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glucose metabolic process  (ISO)
positive regulation of glycogen biosynthetic process  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of lipoprotein lipase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of nitric oxide mediated signal transduction  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein secretion  (IBA)
positive regulation of respiratory burst  (ISO)
protein hexamerization  (ISO)
regulation of gene expression  (ISO)
regulation of phosphorylation  (ISO)
regulation of protein localization  (ISO)
regulation of protein localization to plasma membrane  (ISO)
regulation of protein secretion  (ISO)
vasodilation  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The role of the IDDM2 locus in the susceptibility of UK APS1 subjects to type 1 diabetes mellitus. Adamson KA, etal., Int J Immunogenet. 2007 Feb;34(1):17-21. doi: 10.1111/j.1744-313X.2006.00643.x.
2. Colocalization of chaperone Cpn60, proinsulin and convertase PC1 within immature secretory granules of insulin-secreting cells suggests a role for Cpn60 in insulin processing. Arias AE, etal., J Cell Sci. 2000 Jun;113 ( Pt 11):2075-83.
3. Insulin-induced hypertension in rats depends on an intact renin-angiotensin system. Brands MW, etal., Hypertension. 1997 Apr;29(4):1014-9.
4. Effects of human immunodeficiency virus and metabolic complications on myocardial nutrient metabolism, blood flow, and oxygen consumption: a cross-sectional analysis. Cade WT, etal., Cardiovasc Diabetol. 2011 Dec 8;10:111. doi: 10.1186/1475-2840-10-111.
5. Bacterial and plant enterotoxin B subunit-autoantigen fusion proteins suppress diabetes insulitis. Carter JE, etal., Mol Biotechnol. 2006 Jan;32(1):1-15. doi: 10.1385/MB:32:1:001.
6. Construction and selection of recombinant plasmids containing full-length complementary DNAs corresponding to rat insulins I and II. Chan SJ, etal., Proc Natl Acad Sci U S A 1979 Oct;76(10):5036-40.
7. Familial hyperproinsulinaemia due to a mutation substituting histidine for arginine at position 65 in proinsulin: identification of the mutation by restriction enzyme mapping. Collinet M, etal., Eur J Pediatr. 1998 Jun;157(6):456-60.
8. Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus. Colombo C, etal., J Clin Invest. 2008 Jun;118(6):2148-56.
9. Of mice and MEN1: Insulinomas in a conditional mouse knockout. Crabtree JS, etal., Mol Cell Biol. 2003 Sep;23(17):6075-85.
10. The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. Currie CJ, etal., Diabetologia. 2009 Sep;52(9):1766-77. Epub 2009 Jul 2.
11. The combination of serum insulin, osteopontin, and hepatocyte growth factor predicts time to castration-resistant progression in androgen dependent metastatic prostate cancer- an exploratory study. Dayyani F, etal., BMC Cancer. 2016 Sep 6;16:721. doi: 10.1186/s12885-016-2723-1.
12. Protection of NOD mice from type 1 diabetes after oral inoculation with vaccinia viruses expressing adjuvanted islet autoantigens. Denes B, etal., J Immunother. 2005 Sep-Oct;28(5):438-48. doi: 10.1097/01.cji.0000171315.82997.9a.
13. Growth promoting peptides in osteoarthritis: insulin, insulin-like growth factor-1, growth hormone. Denko CW, etal., J Rheumatol. 1990 Sep;17(9):1217-21.
14. Differential immune response to B:9-23 insulin 1 and insulin 2 peptides in animal models of type 1 diabetes. Devendra D, etal., J Autoimmun. 2004 Aug;23(1):17-26. doi: 10.1016/j.jaut.2004.03.008.
15. Suppression of hyperglycemia in NOD mice after inoculation with recombinant vaccinia viruses. Dénes B, etal., Mol Biotechnol. 2006 Nov;34(3):317-27. doi: 10.1385/MB:34:3:317.
16. Early intensive insulin therapy attenuates the p38 pathway in the renal cortex and indices of nephropathy in diabetic rats. Fang D, etal., Endocr J. 2012;59(1):81-90. Epub 2011 Nov 9.
17. Differential roles of hyperglycemia and hypoinsulinemia in diabetes induced retinal cell death: evidence for retinal insulin resistance. Fort PE, etal., PLoS One. 2011;6(10):e26498. Epub 2011 Oct 26.
18. Loss of cholinergic and dopaminergic amacrine cells in streptozotocin-diabetic rat and Ins2Akita-diabetic mouse retinas. Gastinger MJ, etal., Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3143-50.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein. Grunblatt E, etal., J Neurochem. 2007 May;101(3):757-70.
21. Proinsulin processing in the diabetic Goto-Kakizaki rat. Guest PC, etal., J Endocrinol. 2002 Dec;175(3):637-47.
22. The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load. Holmkvist J, etal., PLoS One. 2009 Jun 11;4(6):e5872.
23. Glycemic exposure is affected favorably by inhaled human insulin (Exubera) as compared with subcutaneous insulin glargine (Lantus) in patients with type 2 diabetes. Hompesch M, etal., Diabetes Technol Ther. 2009 May;11(5):307-13.
24. Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling. Hong EG, etal., Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1687-96. doi: 10.1152/ajpendo.00256.2007. Epub 2007 Oct 2.
25. Insulin action and insulin resistance: diseases involving defects in insulin receptors, signal transduction, and the glucose transport effector system. Hunter SJ and Garvey WT, Am J Med. 1998 Oct;105(4):331-45.
26. Proinsulin by immunochemiluminometric assay for the diagnosis of insulinoma. Kao PC, etal., J Clin Endocrinol Metab. 1994 May;78(5):1048-51.
27. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
28. Glucagon/insulin ratio as a potential biomarker for pancreatic cancer in patients with new-onset diabetes mellitus. Kolb A, etal., Cancer Biol Ther. 2009 Aug;8(16):1527-33. Epub 2009 Aug 13.
29. Point mutations close to the AUG initiator codon affect the efficiency of translation of rat preproinsulin in vivo. Kozak M Nature 1984 Mar 15-21;308(5956):241-6.
30. Polymorphism -23HPhI in the promoter of insulin gene and pancreatic cancer: a pilot study. Krechler T, etal., Neoplasma. 2009;56(1):26-32.
31. The insulin gene VNTR is associated with fasting insulin levels and development of juvenile obesity. Le Stunff C, etal., Nat Genet. 2000 Dec;26(4):444-6.
32. Antidiabetic therapies affect risk of pancreatic cancer. Li D, etal., Gastroenterology. 2009 Aug;137(2):482-8. Epub 2009 Apr 16.
33. Oral Administration of Silkworm-Produced GAD65 and Insulin Bi-Autoantigens against Type 1 Diabetes. Liu B, etal., PLoS One. 2016 Jan 19;11(1):e0147260. doi: 10.1371/journal.pone.0147260. eCollection 2016.
34. The structure and evolution of the two nonallelic rat preproinsulin genes. Lomedico P, etal., Cell 1979 Oct;18(2):545-58.
35. The structure of rat preproinsulin genes. Lomedico PT, etal., Ann N Y Acad Sci 1980;343:425-32.
36. Polymorphism of human leptin receptor gene is associated with type 2 diabetic patients complicated with non-alcoholic fatty liver disease in China. Lu H, etal., J Gastroenterol Hepatol. 2009 Feb;24(2):228-32. Epub 2008 Aug 17.
37. Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells. Malide D, etal., J Histochem Cytochem. 1995 Jan;43(1):11-9.
38. Protection against autoimmune diabetes by silkworm-produced GFP-tagged CTB-insulin fusion protein. Meng Q, etal., Clin Dev Immunol. 2011;2011:831704. doi: 10.1155/2011/831704. Epub 2011 Jun 6.
39. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
40. Associations of serum uric acid with cardiovascular events and mortality in moderate chronic kidney disease. Navaneethan SD and Beddhu S, Nephrol Dial Transplant. 2009 Apr;24(4):1260-6. Epub 2008 Nov 25.
41. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
42. A variant insulin promoter in non-insulin-dependent diabetes mellitus. Olansky L, etal., J Clin Invest. 1992 May;89(5):1596-602.
43. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
44. Risk of autoimmune diabetes in APECED: association with short alleles of the 5'insulin VNTR. Paquette J, etal., Genes Immun. 2010 Oct;11(7):590-7. doi: 10.1038/gene.2010.33. Epub 2010 Jun 10.
45. Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted. Park SY, etal., Biochem Biophys Res Commun. 2010 Jan 15;391(3):1449-54. Epub 2009 Dec 23.
46. Parallel signaling pathways of melatonin in the pancreatic beta-cell. Peschke E, etal., J Pineal Res. 2006 Mar;40(2):184-91.
47. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
48. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
49. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
50. GOA pipeline RGD automated data pipeline
51. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
52. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
53. Comprehensive gene review and curation RGD comprehensive gene curation
54. Localization of proinsulin and insulin in human insulinoma: preliminary immunohistochemical results. Roth J, etal., Virchows Arch B Cell Pathol Incl Mol Pathol. 1989;56(5):287-92.
55. Safety and efficacy of inhaled human insulin (Exubera) during discontinuation and readministration of therapy in adults with type 1 diabetes: A 3-year randomized controlled trial. Skyler JS, etal., Diabetes Res Clin Pract. 2008 Nov;82(2):238-46. Epub 2008 Sep 27.
56. RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon. Soares MB, etal., Mol Cell Biol 1985 Aug;5(8):2090-103.
57. Insulin gene mutations as a cause of permanent neonatal diabetes. Stoy J, etal., Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15040-4. Epub 2007 Sep 12.
58. Association analysis of the AIRE and insulin genes in Finnish type 1 diabetic patients. Turunen JA, etal., Immunogenetics. 2006 Jun;58(5-6):331-8. doi: 10.1007/s00251-006-0088-3. Epub 2006 Mar 22.
59. Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance. Ward WK, etal., Diabetologia. 1987 Sep;30(9):698-702.
60. Assessment of insulin sensitivity/resistance and their relations with leptin concentrations and anthropometric measures in a pregnant population with and without gestational diabetes mellitus. Yilmaz O, etal., J Diabetes Complications. 2009 Mar 6.
61. Regulation of insulin receptor function. Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91.
62. Obesity potentiates the growth and dissemination of pancreatic cancer. Zyromski NJ, etal., Surgery. 2009 Aug;146(2):258-63.
Additional References at PubMed
PMID:381941   PMID:1184755   PMID:2656699   PMID:2967174   PMID:3518947   PMID:3553851   PMID:4311938   PMID:4554104   PMID:4640931   PMID:7513704   PMID:7556975   PMID:7688386  
PMID:7782332   PMID:8069456   PMID:8452530   PMID:8702995   PMID:8844841   PMID:9092559   PMID:9498508   PMID:9507006   PMID:9689059   PMID:9830016   PMID:10508408   PMID:10604997  
PMID:10644978   PMID:11375348   PMID:11443198   PMID:11500939   PMID:11854325   PMID:12038757   PMID:12059784   PMID:12138094   PMID:12488434   PMID:12805218   PMID:14615391   PMID:14677856  
PMID:14739855   PMID:15185208   PMID:15282335   PMID:15473891   PMID:15591776   PMID:15788565   PMID:15792832   PMID:15793245   PMID:17472440   PMID:17925406   PMID:17957153   PMID:17993259  
PMID:18063688   PMID:18165568   PMID:19188609   PMID:19293336   PMID:19727662   PMID:20082125   PMID:20455999   PMID:20738396   PMID:20857410   PMID:21773965   PMID:21821716   PMID:21828338  
PMID:22161251   PMID:22854022   PMID:22990990   PMID:23106816   PMID:23274896   PMID:23416304   PMID:23510797   PMID:23651473   PMID:23775122   PMID:24440707   PMID:24675707   PMID:25002582  
PMID:25403480   PMID:26986474   PMID:27336168   PMID:28410130   PMID:30790128   PMID:32631952   PMID:35562179  


Genomics

Comparative Map Data
Ins2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81207,272,738 - 207,421,998 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1207,272,742 - 207,273,805 (-)EnsemblGRCr8
mRatBN7.21197,843,277 - 197,992,522 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1197,843,281 - 197,864,775 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1206,216,147 - 206,217,214 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,302,063 - 213,303,130 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01205,976,222 - 205,977,289 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01215,856,967 - 215,858,034 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,856,971 - 215,858,034 (-)Ensemblrn6Rnor6.0
Rnor_5.01222,751,786 - 222,756,821 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41202,935,548 - 202,936,379 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1195,461,309 - 195,462,376 (-)NCBICelera
RGSC_v3.11203,123,613 - 203,124,445 (-)NCBI
Cytogenetic Map1q41NCBI
INS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,159,779 - 2,161,209 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl112,159,779 - 2,161,221 (-)Ensemblhg38GRCh38
GRCh37112,181,009 - 2,182,439 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,137,585 - 2,139,015 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34112,137,584 - 2,139,000NCBI
Celera112,217,516 - 2,218,946 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,971,272 - 1,972,702 (-)NCBIHuRef
CHM1_1112,179,957 - 2,181,387 (-)NCBICHM1_1
T2T-CHM13v2.0112,247,427 - 2,248,857 (-)NCBIT2T-CHM13v2.0
Ins2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,232,393 - 142,233,463 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,232,393 - 142,297,118 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387142,678,656 - 142,679,726 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,678,656 - 142,743,381 (-)Ensemblmm10GRCm38
MGSCv377149,864,561 - 149,865,613 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367142,488,051 - 142,489,098 (-)NCBIMGSCv36mm8
Celera7142,434,985 - 142,436,037 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.0NCBI
Ins
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542213,909,407 - 13,910,419 (-)Ensembl
ChiLan1.0NW_00495542213,909,408 - 13,910,419 (-)NCBIChiLan1.0ChiLan1.0
INS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v294,586,153 - 4,587,845 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1113,797,924 - 3,799,616 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0112,200,785 - 2,202,579 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1112,230,309 - 2,231,666 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,218,117 - 2,231,666 (-)EnsemblpanPan2panpan1.1
INS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,324,047 - 46,324,933 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,324,041 - 46,325,122 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1844,933,843 - 44,934,720 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01847,003,520 - 47,004,406 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1847,003,520 - 47,004,411 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11846,452,280 - 46,453,156 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,032,597 - 46,033,483 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,779,045 - 46,779,926 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ins
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049471,748,017 - 1,749,237 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368161,002,137 - 1,003,357 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049368161,002,137 - 1,003,357 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl21,496,842 - 1,497,841 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.121,496,842 - 1,498,052 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
INS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,965,128 - 1,969,090 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603899,163,059 - 99,164,540 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ins
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476714,999,088 - 15,000,035 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476714,999,088 - 15,000,035 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ins2
1092 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:29
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000027656
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1194786607207590403Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1201915593208479939Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
6480777Insul17Insulin level QTL 173.86blood insulin amount (VT:0001560)blood insulin level area under curve (AUC) (CMO:0000351)1206690418207509562Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512213659238Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
AA986540  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21251,245,377 - 251,245,516 (+)MAPPERmRatBN7.2
Rnor_6.01272,800,189 - 272,800,327NCBIRnor6.0
Rnor_5.01280,214,020 - 280,214,158UniSTSRnor5.0
RGSC_v3.41258,001,526 - 258,001,664UniSTSRGSC3.4
Celera1246,946,819 - 246,946,957UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
PMC123023P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,426 - 197,844,133 (+)MAPPERmRatBN7.2
mRatBN7.21251,245,183 - 251,245,392 (+)MAPPERmRatBN7.2
Rnor_6.01272,799,995 - 272,800,203NCBIRnor6.0
Rnor_6.01215,857,117 - 215,857,823NCBIRnor6.0
Rnor_5.01280,213,826 - 280,214,034UniSTSRnor5.0
Rnor_5.01222,751,936 - 222,752,642UniSTSRnor5.0
RGSC_v3.41202,935,638 - 202,936,344UniSTSRGSC3.4
RGSC_v3.41258,001,332 - 258,001,540UniSTSRGSC3.4
Celera1246,946,625 - 246,946,833UniSTS
Celera1195,461,459 - 195,462,165UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
PMC21231P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,360 - 197,844,160 (+)MAPPERmRatBN7.2
mRatBN7.21251,245,156 - 251,245,457 (+)MAPPERmRatBN7.2
Rnor_6.01272,799,968 - 272,800,268NCBIRnor6.0
Rnor_6.01215,857,051 - 215,857,850NCBIRnor6.0
Rnor_5.01280,213,799 - 280,214,099UniSTSRnor5.0
Rnor_5.01222,751,870 - 222,752,669UniSTSRnor5.0
RGSC_v3.41202,935,572 - 202,936,371UniSTSRGSC3.4
RGSC_v3.41258,001,305 - 258,001,605UniSTSRGSC3.4
Celera1246,946,598 - 246,946,898UniSTS
Celera1195,461,393 - 195,462,192UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
PMC21334P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,378 - 197,844,106 (+)MAPPERmRatBN7.2
mRatBN7.21251,245,210 - 251,245,439 (+)MAPPERmRatBN7.2
Rnor_6.01272,800,022 - 272,800,250NCBIRnor6.0
Rnor_6.01215,857,069 - 215,857,796NCBIRnor6.0
Rnor_5.01280,213,853 - 280,214,081UniSTSRnor5.0
Rnor_5.01222,751,888 - 222,752,615UniSTSRnor5.0
RGSC_v3.41202,935,590 - 202,936,317UniSTSRGSC3.4
RGSC_v3.41258,001,359 - 258,001,587UniSTSRGSC3.4
Celera1246,946,652 - 246,946,880UniSTS
Celera1195,461,411 - 195,462,138UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
RH94798  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,844,162 - 197,844,421 (+)MAPPERmRatBN7.2
Rnor_6.01215,857,853 - 215,858,111NCBIRnor6.0
Rnor_5.01222,752,672 - 222,752,930UniSTSRnor5.0
RGSC_v3.41202,936,374 - 202,936,632UniSTSRGSC3.4
Celera1195,462,195 - 195,462,453UniSTS
Cytogenetic Map1q41UniSTS
RH94799  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,380 - 197,844,179 (+)MAPPERmRatBN7.2
mRatBN7.21251,245,137 - 251,245,437 (+)MAPPERmRatBN7.2
Rnor_6.01272,799,949 - 272,800,248NCBIRnor6.0
Rnor_6.01215,857,071 - 215,857,869NCBIRnor6.0
Rnor_5.01280,213,780 - 280,214,079UniSTSRnor5.0
Rnor_5.01222,751,890 - 222,752,688UniSTSRnor5.0
RGSC_v3.41202,935,592 - 202,936,390UniSTSRGSC3.4
RGSC_v3.41258,001,286 - 258,001,585UniSTSRGSC3.4
Celera1246,946,579 - 246,946,878UniSTS
Celera1195,461,413 - 195,462,211UniSTS
RH 3.4 Map11654.9UniSTS
Cytogenetic Map1q54-q55UniSTS
Cytogenetic Map1q41UniSTS
D1Bda44  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,811 - 197,844,346 (+)MAPPERmRatBN7.2
Rnor_6.01215,857,502 - 215,858,036NCBIRnor6.0
Rnor_5.01222,752,321 - 222,752,855UniSTSRnor5.0
RGSC_v3.41202,936,023 - 202,936,557UniSTSRGSC3.4
Celera1195,461,844 - 195,462,378UniSTS
Cytogenetic Map1q41UniSTS
PMC123023P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21251,245,148 - 251,245,480 (+)MAPPERmRatBN7.2
mRatBN7.21197,843,337 - 197,844,168 (+)MAPPERmRatBN7.2
Rnor_6.01215,857,028 - 215,857,858NCBIRnor6.0
Rnor_6.01272,799,960 - 272,800,291NCBIRnor6.0
Rnor_5.01280,213,791 - 280,214,122UniSTSRnor5.0
Rnor_5.01222,751,847 - 222,752,677UniSTSRnor5.0
RGSC_v3.41202,935,549 - 202,936,379UniSTSRGSC3.4
RGSC_v3.41258,001,297 - 258,001,628UniSTSRGSC3.4
Celera1246,946,590 - 246,946,921UniSTS
Celera1195,461,370 - 195,462,200UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
PMC153767P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81207,272,892 - 207,273,604 (+)Marker Load Pipeline
mRatBN7.21197,843,431 - 197,844,143 (+)MAPPERmRatBN7.2
Rnor_6.01215,857,122 - 215,857,833NCBIRnor6.0
Rnor_5.01222,751,941 - 222,752,652UniSTSRnor5.0
RGSC_v3.41202,935,643 - 202,936,354UniSTSRGSC3.4
Celera1195,461,464 - 195,462,175UniSTS
Cytogenetic Map1q41UniSTS
PMC24644P6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,343 - 197,844,030 (+)MAPPERmRatBN7.2
mRatBN7.21251,245,286 - 251,245,474 (+)MAPPERmRatBN7.2
Rnor_6.01272,800,098 - 272,800,285NCBIRnor6.0
Rnor_6.01215,857,034 - 215,857,720NCBIRnor6.0
Rnor_5.01280,213,929 - 280,214,116UniSTSRnor5.0
Rnor_5.01222,751,853 - 222,752,539UniSTSRnor5.0
RGSC_v3.41202,935,555 - 202,936,241UniSTSRGSC3.4
RGSC_v3.41258,001,435 - 258,001,622UniSTSRGSC3.4
Celera1246,946,728 - 246,946,915UniSTS
Celera1195,461,376 - 195,462,062UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
UniSTS:267003  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,338 - 197,844,055 (+)MAPPERmRatBN7.2
mRatBN7.21251,245,261 - 251,245,479 (+)MAPPERmRatBN7.2
Rnor_6.01272,800,073 - 272,800,290NCBIRnor6.0
Rnor_6.01215,857,029 - 215,857,745NCBIRnor6.0
Rnor_5.01280,213,904 - 280,214,121UniSTSRnor5.0
Rnor_5.01222,751,848 - 222,752,564UniSTSRnor5.0
RGSC_v3.41202,935,550 - 202,936,266UniSTSRGSC3.4
RGSC_v3.41258,001,410 - 258,001,627UniSTSRGSC3.4
Celera1246,946,703 - 246,946,920UniSTS
Celera1195,461,371 - 195,462,087UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
UniSTS:462687  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,339 - 197,844,092 (+)MAPPERmRatBN7.2
Rnor_6.01215,857,030 - 215,857,782NCBIRnor6.0
Rnor_5.01222,751,849 - 222,752,601UniSTSRnor5.0
RGSC_v3.41202,935,551 - 202,936,303UniSTSRGSC3.4
Celera1195,461,372 - 195,462,124UniSTS
Cytogenetic Map1q41UniSTS
Ins1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,338 - 197,844,149 (+)MAPPERmRatBN7.2
mRatBN7.21251,245,167 - 251,245,479 (+)MAPPERmRatBN7.2
Rnor_6.01272,799,979 - 272,800,290NCBIRnor6.0
Rnor_6.01215,857,029 - 215,857,839NCBIRnor6.0
Rnor_5.01280,213,810 - 280,214,121UniSTSRnor5.0
Rnor_5.01222,751,848 - 222,752,658UniSTSRnor5.0
RGSC_v3.41258,001,316 - 258,001,627UniSTSRGSC3.4
RGSC_v3.41202,935,550 - 202,936,360UniSTSRGSC3.4
Celera1246,946,609 - 246,946,920UniSTS
Celera1195,461,371 - 195,462,181UniSTS
Cytogenetic Map1q54-q55UniSTS
Cytogenetic Map1q41UniSTS
Ins2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,329 - 197,843,453 (+)MAPPERmRatBN7.2
Rnor_6.01215,857,020 - 215,857,143NCBIRnor6.0
Rnor_5.01222,751,839 - 222,751,962UniSTSRnor5.0
RGSC_v3.41202,935,541 - 202,935,664UniSTSRGSC3.4
Celera1195,461,362 - 195,461,485UniSTS
Cytogenetic Map1q41UniSTS
Ins2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21251,245,333 - 251,245,517 (+)MAPPERmRatBN7.2
Rnor_6.01272,800,145 - 272,800,328NCBIRnor6.0
Rnor_5.01280,213,976 - 280,214,159UniSTSRnor5.0
RGSC_v3.41258,001,482 - 258,001,665UniSTSRGSC3.4
Celera1246,946,775 - 246,946,958UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map1q54-q55UniSTS
Ins1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,843,373 - 197,844,345 (+)MAPPERmRatBN7.2
Rnor_6.01215,857,064 - 215,858,035NCBIRnor6.0
Rnor_5.01222,751,883 - 222,752,854UniSTSRnor5.0
RGSC_v3.41202,935,585 - 202,936,556UniSTSRGSC3.4
Celera1195,461,406 - 195,462,377UniSTS
Cytogenetic Map1q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 1 20 81 55 54 41 83 41 3 219 118 11 72 48 66 13 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010062715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP467629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP472188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP485158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J00748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V01243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000027656   ⟹   ENSRNOP00000027656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1207,272,742 - 207,273,805 (-)Ensembl
mRatBN7.2 Ensembl1197,843,281 - 197,844,344 (-)Ensembl
Rnor_6.0 Ensembl1215,856,971 - 215,858,034 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105489   ⟹   ENSRNOP00000080277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1197,843,281 - 197,864,775 (-)Ensembl
RefSeq Acc Id: NM_019130   ⟹   NP_062003
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,272,738 - 207,273,805 (-)NCBI
mRatBN7.21197,843,277 - 197,844,344 (-)NCBI
Rnor_6.01215,856,967 - 215,858,034 (-)NCBI
Rnor_5.01222,751,786 - 222,756,821 (-)NCBI
RGSC_v3.41202,935,548 - 202,936,379 (-)RGD
Celera1195,461,309 - 195,462,376 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063280751   ⟹   XP_063136821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,272,744 - 207,403,024 (-)NCBI
RefSeq Acc Id: XR_010062665
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,581 (-)NCBI
RefSeq Acc Id: XR_010062666
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,581 (-)NCBI
RefSeq Acc Id: XR_010062667
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,581 (-)NCBI
RefSeq Acc Id: XR_010062668
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,577 (-)NCBI
RefSeq Acc Id: XR_010062669
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,581 (-)NCBI
RefSeq Acc Id: XR_010062670
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,421,998 (-)NCBI
RefSeq Acc Id: XR_010062671
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,581 (-)NCBI
RefSeq Acc Id: XR_010062672
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,421,998 (-)NCBI
RefSeq Acc Id: XR_010062673
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,581 (-)NCBI
RefSeq Acc Id: XR_010062674
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,421,998 (-)NCBI
RefSeq Acc Id: XR_010062675
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,581 (-)NCBI
RefSeq Acc Id: XR_010062676
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,577 (-)NCBI
RefSeq Acc Id: XR_010062678
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,581 (-)NCBI
RefSeq Acc Id: XR_010062679
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,581 (-)NCBI
RefSeq Acc Id: XR_010062680
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,581 (-)NCBI
RefSeq Acc Id: XR_010062681
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,581 (-)NCBI
RefSeq Acc Id: XR_010062682
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,581 (-)NCBI
RefSeq Acc Id: XR_010062684
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,581 (-)NCBI
RefSeq Acc Id: XR_010062685
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,581 (-)NCBI
RefSeq Acc Id: XR_010062686
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,569 (-)NCBI
RefSeq Acc Id: XR_010062689
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,581 (-)NCBI
RefSeq Acc Id: XR_010062692
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,581 (-)NCBI
RefSeq Acc Id: XR_010062695
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,581 (-)NCBI
RefSeq Acc Id: XR_010062697
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,581 (-)NCBI
RefSeq Acc Id: XR_010062699
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,581 (-)NCBI
RefSeq Acc Id: XR_010062701
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,421,869 (-)NCBI
RefSeq Acc Id: XR_010062703
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,581 (-)NCBI
RefSeq Acc Id: XR_010062704
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,577 (-)NCBI
RefSeq Acc Id: XR_010062705
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,581 (-)NCBI
RefSeq Acc Id: XR_010062709
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,414,581 (-)NCBI
RefSeq Acc Id: XR_010062710
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,380,546 (-)NCBI
RefSeq Acc Id: XR_010062712
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,384,050 (-)NCBI
RefSeq Acc Id: XR_010062714
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,377,963 (-)NCBI
RefSeq Acc Id: XR_010062715
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,296,780 - 207,382,726 (-)NCBI
Protein Sequences
Protein RefSeqs NP_062003 (Get FASTA)   NCBI Sequence Viewer  
  XP_063136821 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41440 (Get FASTA)   NCBI Sequence Viewer  
  AAA41443 (Get FASTA)   NCBI Sequence Viewer  
  CAA24560 (Get FASTA)   NCBI Sequence Viewer  
  EDM12162 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027656
  ENSRNOP00000027656.1
GenBank Protein P01323 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062003   ⟸   NM_019130
- Peptide Label: preproprotein
- UniProtKB: P01323 (UniProtKB/Swiss-Prot),   A6HY81 (UniProtKB/TrEMBL),   A6JHT1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027656   ⟸   ENSRNOT00000027656
Ensembl Acc Id: ENSRNOP00000080277   ⟸   ENSRNOT00000105489
RefSeq Acc Id: XP_063136821   ⟸   XM_063280751
- Peptide Label: isoform X1
- UniProtKB: A6JHT1 (UniProtKB/TrEMBL),   A0A8I6G4B8 (UniProtKB/TrEMBL)
Protein Domains
Insulin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01323-F1-model_v2 AlphaFold P01323 1-110 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:6850050
Promoter ID:EP17070
Type:single initiation site
Name:RN_INS2
Description:Insulin II, INS2 or INS-2 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 45; Mammalian insulin.
Experiment Methods:Nuclease protection; experiments performed with closely related; gene; Primer extension; experiments performed with closely related; gene; Nuclease protection; transfected or transformed cells; experiments; performed with closely related gene; Primer extension; transfected or transformed cells; experiments; performed with closely related gene
Regulation:pancreas islet b' (repressed by or weakly expressed in) cells; (induced by or strongly expressed in) glucose
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.41202,936,557 - 202,936,617EPD
RGD ID:13690567
Promoter ID:EPDNEW_R1092
Type:single initiation site
Name:Ins2_1
Description:insulin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01215,858,034 - 215,858,094EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2916 AgrOrtholog
BioCyc Gene G2FUF-56892 BioCyc
Ensembl Genes ENSRNOG00000020405 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027656 ENTREZGENE
  ENSRNOT00000027656.4 UniProtKB/Swiss-Prot
Gene3D-CATH Insulin-like UniProtKB/Swiss-Prot
InterPro Insulin UniProtKB/Swiss-Prot
  Insulin-like UniProtKB/Swiss-Prot
  Insulin-like_sf UniProtKB/Swiss-Prot
  Insulin_CS UniProtKB/Swiss-Prot
  Insulin_family UniProtKB/Swiss-Prot
KEGG Report rno:24506 UniProtKB/Swiss-Prot
NCBI Gene 24506 ENTREZGENE
PANTHER INSULIN-2 UniProtKB/Swiss-Prot
  PTHR11454 UniProtKB/Swiss-Prot
Pfam Insulin UniProtKB/Swiss-Prot
PhenoGen Ins2 PhenoGen
PRINTS INSULIN UniProtKB/Swiss-Prot
  INSULINFAMLY UniProtKB/Swiss-Prot
PROSITE INSULIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020405 RatGTEx
SMART IlGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56994 UniProtKB/Swiss-Prot
UniProt A0A8I6G4B8 ENTREZGENE
  A6HY81 ENTREZGENE, UniProtKB/TrEMBL
  A6JHT1 ENTREZGENE, UniProtKB/TrEMBL
  INS2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ins2  insulin 2  LOC102549619  uncharacterized LOC102549619  Data merged from RGD:7640573 737654 PROVISIONAL
2013-12-18 LOC102549619  uncharacterized LOC102549619      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-11-06 Ins2  insulin 2    Insulin 2  Name updated 625702 APPROVED
2002-06-10 Ins2  Insulin 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript contains two introns 729274