GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ins2 | decreases secretion | ISO | INS (Homo sapiens) | 6480464 | CTD | INS protein results in decreased secretion of Nitric Oxide | PMID:26364587 | Ins2 | increases chemical synthesis | ISO | INS (Homo sapiens) | 6480464 | CTD | INS protein results in increased chemical synthesis of Nitric Oxide | PMID:23504962 | Ins2 | increases secretion | ISO | INS (Homo sapiens) | 6480464 | CTD | INS protein results in increased secretion of Nitric Oxide | PMID:20960276 | Ins2 | multiple interactions | ISO | INS (Homo sapiens) | 6480464 | CTD | [INS protein co-treated with Glucose] results in decreased chemical synthesis of Nitric Oxide; [Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide; Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]; Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased chemical synthesis of Nitric Oxide]; Orotic Acid inhibits the reaction [INS protein results in increased abundance of Nitric Oxide]; Palmitates inhibits the reaction [INS protein results in increased chemical synthesis of Nitric Oxide]; PIK3CA protein inhibits the reaction [[Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased chemical synthesis of Nitric Oxide]]; Quercetin inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased chemical synthesis of Nitric Oxide]]; resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]; SIRT1 protein affects the reaction [INS protein results in increased secretion of Nitric Oxide]; SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]]; Sodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased chemical synthesis of Nitric Oxide]] | PMID:20960276 PMID:23504962 PMID:25601987 PMID:28951307 | | ||||||||||||||||||||||
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