GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ins2 | increases expression | EXP | | 6480464 | CTD | Fructose results in increased expression of INS protein; Fructose results in increased expression of INS2 mRNA | PMID:23533474 PMID:25268984 PMID:26713546 | Ins2 | multiple interactions | EXP | | 6480464 | CTD | Curcumin inhibits the reaction [Fructose results in increased expression of INS protein]; Hemin inhibits the reaction [Fructose results in increased expression of INS protein]; INS protein inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA]; Quercetin inhibits the reaction [Fructose results in increased expression of INS2 mRNA] | PMID:18360027 PMID:23533474 PMID:25268984 PMID:26713546 | Ins2 | decreases response to substance | ISO | INS (Homo sapiens) | 6480464 | CTD | Fructose results in decreased susceptibility to INS protein | PMID:12010179 | Ins2 | increases secretion | ISO | INS (Homo sapiens) | 6480464 | CTD | Fructose results in increased secretion of INS protein | PMID:23533474 | | ||||||||||||||||||||||
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