GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ins2 | decreases expression | EXP | | 6480464 | CTD | sodium arsenite results in decreased expression of INS2 mRNA; sodium arsenite results in decreased expression of INS2 protein | PMID:32531573 | Ins2 | decreases activity | ISO | INS (Homo sapiens) | 6480464 | CTD | sodium arsenite results in decreased activity of INS protein | PMID:29526746 | Ins2 | decreases expression | ISO | Ins2 (Mus musculus) | 6480464 | CTD | sodium arsenite results in decreased expression of INS2 mRNA | PMID:37682722 | Ins2 | decreases response to substance | ISO | INS (Homo sapiens) | 6480464 | CTD | INS protein results in decreased susceptibility to sodium arsenite; sodium arsenite results in decreased susceptibility to INS protein | PMID:25982963 PMID:37956786 | Ins2 | multiple interactions | ISO | Ins2 (Mus musculus) | 6480464 | CTD | [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of INS2 protein; Plant Extracts inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic Trioxide] which results in decreased expression of INS2 protein]; sodium arsenite inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] | PMID:21396911 PMID:32226249 | Ins2 | multiple interactions | ISO | INS (Homo sapiens) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in decreased susceptibility to sodium arsenite]; [Glucose co-treated with sodium arsenite] results in increased secretion of INS protein; [INS protein co-treated with sodium arsenite] results in decreased expression of and results in decreased phosphorylation of IRS1 protein; [INS protein co-treated with sodium arsenite] results in decreased phosphorylation of AKT1 protein; [INS protein co-treated with sodium arsenite] results in increased expression of MIR191 mRNA; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with INS protein co-treated with sodium arsenite] results in decreased phosphorylation of AKT1 protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with INS protein co-treated with sodium arsenite] results in decreased phosphorylation of GSK3B protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with INS protein co-treated with sodium arsenite] results in increased expression of and results in increased cleavage of GSDMD protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with INS protein co-treated with sodium arsenite] results in increased expression of IL18 protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with INS protein co-treated with sodium arsenite] results in increased expression of IL1B protein; [sodium arsenite results in increased abundance of arsenite] inhibits the reaction [Glucose results in increased secretion of INS protein]; AKT activator SC79 inhibits the reaction [[INS protein co-treated with sodium arsenite] results in decreased phosphorylation of AKT1 protein]; BQ 610 affects the reaction [sodium arsenite inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ mRNA]]; GSDMD protein affects the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with INS protein co-treated with sodium arsenite] results in decreased phosphorylation of AKT1 protein]; GSDMD protein affects the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with INS protein co-treated with sodium arsenite] results in decreased phosphorylation of GSK3B protein]; GSDMD protein affects the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with INS protein co-treated with sodium arsenite] results in increased expression of IL18 protein]; GSDMD protein affects the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with INS protein co-treated with sodium arsenite] results in increased expression of IL1B protein]; INS protein inhibits the reaction [sodium arsenite results in decreased expression of SIRT1 protein]; INS protein inhibits the reaction [sodium arsenite results in decreased phosphorylation of AKT1 protein]; IRS1 protein affects the reaction [MIR191 mRNA affects the reaction [[INS protein co-treated with sodium arsenite] results in decreased phosphorylation of AKT1 protein]]; IRS1 protein inhibits the reaction [MIR191 mRNA affects the reaction [[INS protein co-treated with sodium arsenite] results in decreased expression of and results in decreased phosphorylation of IRS1 protein]]; MIR191 mRNA affects the reaction [[INS protein co-treated with sodium arsenite] results in decreased expression of and results in decreased phosphorylation of IRS1 protein]; MIR191 mRNA affects the reaction [[INS protein co-treated with sodium arsenite] results in decreased phosphorylation of AKT1 protein]; RES 701-1 affects the reaction [sodium arsenite inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ mRNA]]; sodium arsenite affects the reaction [Pertussis Toxin promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ mRNA]]; sodium arsenite inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ mRNA]; sodium arsenite inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of CEBPA mRNA]; sodium arsenite inhibits the reaction [Glucose results in increased secretion of INS protein]; sodium arsenite inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; sodium arsenite inhibits the reaction [INS protein results in increased phosphorylation of GSK3B protein]; sodium arsenite inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]; sodium arsenite inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]; sodium arsenite inhibits the reaction [INS protein results in increased uptake of Glucose]; sodium arsenite promotes the reaction [Potassium Chloride results in increased secretion of INS protein]; TPH1 protein affects the reaction [sodium arsenite inhibits the reaction [Glucose results in increased secretion of INS protein]]; TPH1 protein affects the reaction [UGT1A6A protein affects the reaction [sodium arsenite inhibits the reaction [Glucose results in increased secretion of INS protein]]]; triciribine inhibits the reaction [INS protein results in decreased susceptibility to sodium arsenite]; UGT1A6A protein affects the reaction [sodium arsenite inhibits the reaction [Glucose results in increased secretion of INS protein]] | PMID:20100676 PMID:23152186 PMID:24535192 PMID:25982963 PMID:29526746 PMID:30562058 PMID:31555879 PMID:33743404 PMID:34118311 PMID:34920032 | | ||||||||||||||||||||||
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