Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2916
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ins2
Name: insulin 2
Acc ID: CHEBI:34682
Term: diazinon
Definition: A member of the class of pyrimidines that is pyrimidine carrying an isopropyl group at position 2, a methyl group at position 6 and a (diethoxyphosphorothioyl)oxy group at position 4.
Chemical ID: MESH:D003976
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ins2decreases secretionISOINS (Homo sapiens)6480464CTDDiazinon results in decreased secretion of INS protein; Diazinon results in decreased secretion of INS protein alternative formPMID:27920530
Ins2increases methylationISOINS (Homo sapiens)6480464CTDDiazinon results in increased methylation of INS genePMID:22964155
Ins2multiple interactionsISOINS (Homo sapiens)6480464CTD[Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in decreased secretion of INS protein alternative form]; [Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in decreased secretion of INS protein]; Magnesium Oxide analog inhibits the reaction [Diazinon results in decreased secretion of INS protein alternative form]; Magnesium Oxide analog inhibits the reaction [Diazinon results in decreased secretion of INS protein]; Selenium analog inhibits the reaction [Diazinon results in decreased secretion of INS protein alternative form]; Selenium analog inhibits the reaction [Diazinon results in decreased secretion of INS protein]PMID:27920530
Go Back to source page   Continue to Ontology report