GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ins2 | decreases expression | EXP | | 6480464 | CTD | Streptozocin results in decreased expression of INS protein | PMID:11216864 | Ins2 | multiple interactions | EXP | | 6480464 | CTD | INS protein inhibits the reaction [Streptozocin results in decreased expression of FASN mRNA]; INS protein inhibits the reaction [Streptozocin results in decreased expression of POMC mRNA]; INS protein inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; INS protein inhibits the reaction [Streptozocin results in increased expression of AGRP mRNA]; INS protein inhibits the reaction [Streptozocin results in increased expression of NPY mRNA]; INS protein promotes the reaction [Streptozocin results in decreased activity of SOD2 protein]; INS protein promotes the reaction [Streptozocin results in increased activity of GSR protein]; INS protein promotes the reaction [Streptozocin results in increased expression of PPARG mRNA] | PMID:20219977 PMID:22940631 | Ins2 | multiple interactions | ISO | Ins2 (Mus musculus) | 6480464 | CTD | [Dietary Fats co-treated with Streptozocin] results in decreased expression of INS2 mRNA; [Diethylhexyl Phthalate co-treated with Streptozocin co-treated with Dietary Fats] results in increased expression of INS2 mRNA; [Streptozocin co-treated with Dietary Fats co-treated with Diethylhexyl Phthalate] results in increased expression of INS2 protein; [Streptozocin co-treated with Dietary Fats] results in decreased expression of INS2 mRNA; Diethylhexyl Phthalate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of INS2 mRNA]; INS protein inhibits the reaction [Streptozocin results in decreased activity of SOD3 protein]; INS protein inhibits the reaction [Streptozocin results in decreased expression of ATP7A protein] | PMID:23884884 PMID:33359794 PMID:33484791 | Ins2 | multiple interactions | ISO | INS (Homo sapiens) | 6480464 | CTD | INS protein inhibits the reaction [Streptozocin results in decreased expression of NES mRNA]; Resveratrol inhibits the reaction [Streptozocin inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]]; Streptozocin inhibits the reaction [INS protein results in increased phosphorylation of INSR protein] | PMID:19388005 PMID:25808216 | | ||||||||||||||||||||||
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