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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2916
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ins2
Name: insulin 2
Acc ID: CHEBI:17634
Term: D-glucose
Definition: A glucose with D-configuration.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ins2decreases expressionEXP 6480464CTDGlucose results in decreased expression of INS2 mRNAPMID:12914525
Ins2increases expressionEXP 6480464CTDGlucose results in increased expression of INS mRNA; Glucose results in increased expression of INS2 mRNA alternative formPMID:22558381 PMID:9142872
Ins2increases uptakeEXP 6480464CTDINS protein results in increased uptake of GlucosePMID:18266981 PMID:35577173 PMID:8725009
Ins2multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Dexamethasone inhibits the reaction [Glucose results in increased secretion of INS protein]]; Dexamethasone inhibits the reaction [Glucose results in increased secretion of INS protein]; IKBKB affects the reaction [IL1B protein inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]]; IKBKB affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]]; IL1B protein inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]; lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]; Palmitic Acid inhibits the reaction [INS protein results in increased uptake of Glucose]; Quercetin inhibits the reaction [INS protein results in increased uptake of Glucose]; sodium bisulfide inhibits the reaction [INS protein results in increased uptake of Glucose]PMID:21888768 PMID:22558381 PMID:35577173 PMID:8725009
Ins2affects response to substanceISOINS (Homo sapiens)6480464CTDGlucose affects the susceptibility to INS proteinPMID:30914352
Ins2decreases chemical synthesisISOINS (Homo sapiens)6480464CTDGlucose results in decreased chemical synthesis of INS proteinPMID:20520763
Ins2decreases secretionISOINS (Homo sapiens)6480464CTDGlucose results in decreased secretion of INS proteinPMID:15642492 PMID:16452552
Ins2increases activityISOINS (Homo sapiens)6480464CTDGlucose results in increased activity of INS promoterPMID:16489446
Ins2increases expressionISOIns2 (Mus musculus)6480464CTDGlucose results in increased expression of INS2 mRNA alternative formPMID:22558381
Ins2increases secretionISOIns2 (Mus musculus)6480464CTDGlucose results in increased secretion of INS protein; Glucose results in increased secretion of INS2 proteinPMID:10967106 PMID:18446233 PMID:28774890
Ins2increases secretionISOINS (Homo sapiens)6480464CTDGlucose results in increased secretion of INS protein; Glucose results in increased secretion of INS protein alternative form; INS protein results in increased secretion of GlucosePMID:10430617 PMID:14625208 PMID:15153144 PMID:15531508 PMID:16204373 PMID:17192482 PMID:18167556 PMID:18347054 PMID:19188863 PMID:20100676 PMID:21163946 PMID:22242153 PMID:25851902 PMID:28180948 PMID:30562058 PMID:31555879 PMID:31776611 PMID:35457000 PMID:35563431 PMID:838844 PMID:9032110
Ins2increases uptakeISOIns2 (Mus musculus)6480464CTDINS protein results in increased uptake of GlucosePMID:24231106
Ins2increases uptakeISOINS (Homo sapiens)6480464CTDINS protein results in increased uptake of GlucosePMID:15277403 PMID:18328801 PMID:19531641 PMID:24651439 PMID:25796170 PMID:29330302 PMID:29526746 PMID:32623698
Ins2multiple interactionsISOIns2 (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [triphenyl phosphate promotes the reaction [INS protein results in increased import of Glucose]]; 3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [INS protein results in increased uptake of Glucose]; [IL1B protein co-treated with IFNG protein] promotes the reaction [Glucose results in increased secretion of INS protein]; bisphenol A promotes the reaction [Glucose results in increased secretion of INS protein]; Estradiol promotes the reaction [Glucose results in increased secretion of INS2 protein]; IL1B protein inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]; lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]; MIR338 mRNA affects the reaction [Glucose results in increased secretion of INS protein]; Palmitic Acid inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]; PDX1 protein affects the reaction [bisphenol A promotes the reaction [Glucose results in increased secretion of INS protein]]; perfluorooctane sulfonic acid promotes the reaction [INS protein results in increased uptake of Glucose]; resveratrol inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [INS protein results in increased uptake of Glucose]]; TLR4 affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]]; triphenyl phosphate promotes the reaction [INS protein results in increased import of Glucose]PMID:10967106 PMID:18446233 PMID:22558381 PMID:24231106 PMID:26548598 PMID:28163246 PMID:28774890
Ins2multiple interactionsISOINS (Homo sapiens)6480464CTD(R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; (R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of ELOVL6 mRNA]; (R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; (R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; (R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; (R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein]; 1-Methyl-3-isobutylxanthine promotes the reaction [Glucose results in increased secretion of INS protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Fatty Acids, Nonesterified inhibits the reaction [INS protein results in increased secretion of Glucose]]; 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of ELOVL6 mRNA]; 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of ACADSB mRNA]; 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein]; 3,4-dihydro-5-methyl-1(2H)-isoquinolinone inhibits the reaction [Glucose inhibits the reaction [MAFA protein binds to INS promoter]]; 3,4-dihydro-5-methyl-1(2H)-isoquinolinone inhibits the reaction [Glucose results in increased expression of INS mRNA]; 3,4-dihydro-5-methyl-1(2H)-isoquinolinone inhibits the reaction [Glucose results in increased expression of INS protein]; 3-aminobenzamide inhibits the reaction [Glucose inhibits the reaction [MAFA protein binds to INS promoter]]; 3-aminobenzamide inhibits the reaction [Glucose results in increased expression of INS mRNA]; 3-aminobenzamide inhibits the reaction [Glucose results in increased expression of INS protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein inhibits the reaction [Resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]]; [6alpha-ethyl-23(S)-methylcholic acid co-treated with Glucose] results in increased secretion of INS protein; [Cadmium Chloride results in increased abundance of Cadmium] inhibits the reaction [Glucose results in increased secretion of INS protein]; [chromic chloride results in increased activity of INS protein modified form] which results in increased import of Glucose; [Glucose affects the susceptibility to INS protein] which affects the phosphorylation of AKT1 protein; [Glucose affects the susceptibility to INS protein] which affects the uptake of Glucose; [Glucose co-treated with INS protein] affects the localization of PDX1 protein; [Glucose co-treated with sodium arsenite] results in increased secretion of INS protein; [Glyburide co-treated with Glucose] results in increased expression of INS protein; [INS protein co-treated with Glucose] results in decreased chemical synthesis of Nitric Oxide; [INS protein co-treated with Glucose] results in decreased expression of SLC2A3 protein; [INS protein co-treated with Glucose] results in increased expression of ACACA mRNA; [INS protein co-treated with Glucose] results in increased expression of FASN mRNA; [INS protein co-treated with Glucose] results in increased expression of SREBF1 mRNA; [Lithocholic Acid co-treated with Glucose] results in increased secretion of INS protein; [manganese chloride results in increased abundance of Manganese] inhibits the reaction [Glucose results in increased secretion of INS protein]; [Oleanolic Acid co-treated with Glucose] results in increased secretion of INS protein; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of ELOVL6 mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of PPARG mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of ACADSB mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of PPARA mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of CCL2 mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of CCL5 mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of CXCL5 mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NFKB1 mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of PPARD mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of RELA mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein; [SB 203580 co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]; [sodium arsenite results in increased abundance of arsenite] inhibits the reaction [Glucose results in increased secretion of INS protein]; [TNF protein co-treated with IFNG protein co-treated with IL1B protein] inhibits the reaction [Glucose results in increased secretion of INS protein alternative form]; [Wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]; Acetylcysteine inhibits the reaction [Glucose results in increased expression of INS protein]; Acetylcysteine inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS protein]]; alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol promotes the reaction [Glucose results in increased secretion of INS protein]; Arachidonic Acid promotes the reaction [Glucose results in increased secretion of INS protein]; arachidonyltrifluoromethane inhibits the reaction [Glucose results in increased secretion of INS protein]; baicalein promotes the reaction [Glucose results in increased secretion of INS protein]; Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein]; bisphenol A inhibits the reaction [INS protein results in increased uptake of Glucose]; bisphenol A promotes the reaction [Glucose results in increased secretion of INS protein]; Cadmium Chloride promotes the reaction [Glucose results in increased secretion of INS protein]; Chlorpropamide inhibits the reaction [Glucose results in decreased secretion of INS protein]; Dexamethasone inhibits the reaction [Glucose results in increased secretion of INS protein]; Dexamethasone inhibits the reaction [INS protein results in increased uptake of Glucose]; Diazoxide inhibits the reaction [Glucose results in increased secretion of INS protein]; Dichlorodiphenyl Dichloroethylene promotes the reaction [Glucose results in increased secretion of INS protein]; Diethylhexyl Phthalate affects the reaction [Glucose results in increased secretion of INS protein]; Enalaprilat inhibits the reaction [Glucose results in decreased secretion of INS protein]; Exenatide inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Glucose results in increased secretion of INS protein alternative form]]; Fatty Acids, Nonesterified inhibits the reaction [INS protein results in increased secretion of Glucose]; Fenofibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Fenofibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; Fenofibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; Fulvestrant inhibits the reaction [bisphenol A inhibits the reaction [INS protein results in increased uptake of Glucose]]; Fulvestrant inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS protein]]; fumosorinone promotes the reaction [INS protein results in increased uptake of Glucose]; Glucose inhibits the reaction [INS protein results in increased chemical synthesis of Glycogen]; Glucose inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; Glucose inhibits the reaction [INS protein results in increased phosphorylation of GSK3B protein]; Glucose inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]; Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]; Glyburide inhibits the reaction [Glucose results in decreased secretion of INS protein]; GW8510 promotes the reaction [Glucose results in increased secretion of INS protein]; HNF1B protein inhibits the reaction [bisphenol A inhibits the reaction [INS protein results in increased uptake of Glucose]]; IAPP protein inhibits the reaction [Glucose results in increased secretion of INS protein]; INS protein inhibits the reaction [Glucose results in decreased expression of ATP1A1 protein]; INS protein mutant form results in decreased uptake of and results in decreased oxidation of Glucose; IRS1 protein polymorphism inhibits the reaction [Glucose results in increased secretion of INS protein]; Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased chemical synthesis of Nitric Oxide]; Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased expression of SLC2A3 protein]; lanifibranor affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; lanifibranor affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of ELOVL6 mRNA]; lanifibranor affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; lanifibranor inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; lanifibranor inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; lanifibranor inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein]; mercaptosteroid 6 inhibits the reaction [Glucose results in increased secretion of INS protein]; Metformin inhibits the reaction [[Glucose affects the susceptibility to INS protein] which affects the uptake of Glucose]; Metformin promotes the reaction [Glucose results in increased secretion of INS protein]; methylarsine oxide inhibits the reaction [Glucose results in increased secretion of INS protein]; Methylcholanthrene promotes the reaction [Glucose results in increased secretion of INS protein alternative form]; MIR133A1 affects the reaction [Glucose results in decreased chemical synthesis of INS protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide promotes the reaction [Glucose results in increased secretion of INS protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased phosphorylation of GSK3B protein]]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]]; Niacinamide inhibits the reaction [Glucose inhibits the reaction [MAFA protein binds to INS promoter]]; Niacinamide inhibits the reaction [Glucose results in increased expression of INS mRNA]; Niacinamide inhibits the reaction [Glucose results in increased expression of INS protein]; NKX6-1 protein promotes the reaction [Glucose results in increased secretion of INS protein]; palmitoyl trifluoromethyl ketone inhibits the reaction [Glucose results in increased secretion of INS protein]; PARP1 protein affects the reaction [Glucose inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]]; perfluorooctane sulfonic acid promotes the reaction [Glucose results in increased secretion of INS protein]; perfluorooctanoic acid inhibits the reaction [Glucose results in increased secretion of INS protein]; Pioglitazone affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Pioglitazone affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; Pioglitazone inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; Pioglitazone inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; Pioglitazone inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein]; Plant Extracts inhibits the reaction [[Glucose affects the susceptibility to INS protein] which affects the uptake of Glucose]; PPARG protein affects the reaction [Fulvestrant inhibits the reaction [bisphenol A inhibits the reaction [INS protein results in increased uptake of Glucose]]]; Quercetin inhibits the reaction [Glucose results in increased expression of INS protein]; Resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]; Resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]; Ro 32-0432 inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS protein]]; Rosiglitazone affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Rosiglitazone affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of ELOVL6 mRNA]; Rosiglitazone affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; Rosiglitazone affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of ACADSB mRNA]; Rosiglitazone inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; Rosiglitazone inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; Rosiglitazone inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein]; Rosiglitazone inhibits the reaction [Fatty Acids, Nonesterified inhibits the reaction [INS protein results in increased secretion of Glucose]]; Rosiglitazone inhibits the reaction [IAPP protein inhibits the reaction [Glucose results in increased secretion of INS protein]]; Rosiglitazone promotes the reaction [INS protein results in increased uptake of Glucose]; Saquinavir inhibits the reaction [INS protein results in increased import of Glucose]; saroglitazar affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; saroglitazar affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of ELOVL6 mRNA]; saroglitazar affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; saroglitazar inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; saroglitazar inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; saroglitazar inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein]; SIRT1 protein affects the reaction [Resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]]; SIRT1 protein inhibits the reaction [Resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]; SLC30A8 protein promotes the reaction [Glucose results in increased secretion of INS protein]; sodium arsenite inhibits the reaction [Glucose results in increased secretion of INS protein]; sodium arsenite inhibits the reaction [INS protein results in increased uptake of Glucose]; SRT1720 inhibits the reaction [[INS protein co-treated with Glucose] results in increased expression of ACACA mRNA]; SRT1720 inhibits the reaction [[INS protein co-treated with Glucose] results in increased expression of FASN mRNA]; SRT1720 inhibits the reaction [[INS protein co-treated with Glucose] results in increased expression of SREBF1 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Glucose results in increased secretion of INS protein alternative form]; Thapsigargin inhibits the reaction [Glucose results in increased secretion of INS protein alternative form]; Thioctic Acid inhibits the reaction [Glucose results in increased expression of INS protein]; TNF protein inhibits the reaction [INS protein results in increased uptake of Glucose]; TPH1 protein affects the reaction [Glucose results in increased secretion of INS protein]; TPH1 protein affects the reaction [sodium arsenite inhibits the reaction [Glucose results in increased secretion of INS protein]]; TPH1 protein affects the reaction [UGT1A6A protein affects the reaction [sodium arsenite inhibits the reaction [Glucose results in increased secretion of INS protein]]]; tributyltin promotes the reaction [Glucose results in increased secretion of INS protein]; triphenyl phosphate promotes the reaction [Glucose results in increased secretion of INS protein]; Troglitazone inhibits the reaction [TNF protein inhibits the reaction [INS protein results in increased uptake of Glucose]]; UCP3 protein promotes the reaction [Glucose results in increased secretion of INS protein]; UGT1A6A protein affects the reaction [sodium arsenite inhibits the reaction [Glucose results in increased secretion of INS protein]]PMID:10430617 PMID:11305519 PMID:11574405 PMID:11786383 PMID:14625208 PMID:15277403 PMID:15531508 PMID:15642492 PMID:15864539 PMID:16204373 PMID:16452552 PMID:16505238 PMID:16984975 PMID:17192482 PMID:17965850 PMID:18167556 PMID:18328801 PMID:18347054 PMID:19724016 PMID:20100676 PMID:20520763 PMID:20960276 PMID:21031461 PMID:21163946 PMID:22162761 PMID:22242153 PMID:23022524 PMID:25796170 PMID:25851902 PMID:28180948 PMID:28951307 PMID:29526746 PMID:30562058 PMID:30914352 PMID:31555879 PMID:31776611 PMID:32613381 PMID:32623698 PMID:3511099 PMID:35457000 PMID:35563431 PMID:7956951
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