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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2916 Species: Rattus norvegicus RGD Object: Gene Symbol: Ins2 Name: insulin 2

Acc ID: CHEBI:9288 Term: streptozocin Definition: An antibiotic that is produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals. CasRN: 18883-66-4 Chemical ID: MESH:D013311

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:731056	6480464	CTD	INS inhibits the reaction [Streptozocin results in decreased expression of AKT1 mRNA] INS inhibits the reaction [Streptozocin results in decreased expression of GSK3B protein] INS inhibits the reaction [Streptozocin results in decreased phosphorylation of GSK3B protein] INS inhibits the reaction [Streptozocin results in decreased expression of PIK3C2G mRNA]	PMID:19136650
multiple interactions	ISO	RGD:731056	6480464	CTD	INS protein inhibits the reaction [Streptozocin results in decreased expression of NES mRNA]	PMID:19388005
multiple interactions	EXP		6480464	CTD	INS protein inhibits the reaction [Streptozocin results in decreased expression of FASN mRNA] INS protein inhibits the reaction [Streptozocin results in decreased expression of POMC mRNA] INS protein inhibits the reaction [Streptozocin results in increased expression of AGRP mRNA] INS protein inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA] INS protein inhibits the reaction [Streptozocin results in increased expression of NPY mRNA] INS protein promotes the reaction [Streptozocin results in increased expression of PPARG mRNA]	PMID:20219977
decreases expression	EXP		6480464	CTD	Streptozocin results in decreased expression of INS protein	PMID:11216864