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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2916
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ins2
Name: insulin 2
Acc ID: CHEBI:3650
Term: chlorpropamide
Definition: An N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is substituted by 4-chlorobenzenesulfonyl group and a hydrogen attached to the other nitrogen is substituted by propyl group. Chlorpropamide is a hypoglycaemic agent used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus not responding to dietary modification.
Chemical ID: MESH:D002747
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ins2decreases expressionISOINS (Homo sapiens)6480464CTDChlorpropamide results in decreased expression of INS proteinPMID:15642492
Ins2increases expressionISOINS (Homo sapiens)6480464CTDChlorpropamide results in increased expression of INS mRNAPMID:15642492
Ins2multiple interactionsISOINS (Homo sapiens)6480464CTDChlorpropamide inhibits the reaction [Glucose results in decreased secretion of INS protein]PMID:15642492
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