ANDROGEN SIGNALING PATHWAY (PW:0000564)

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Description

The androgen signaling pathway plays important roles in the development and maintenance of male phenotype and reproductive functions and in a range of other processes in nonreproductive tissues. Testosterone, the main androgen, is primarily synthesized in the testes; others are synthesized in the adrenal gland and can be converted to testosterone in peripheral tissues. In some of the target cells, testosterone can be converted to its very potent metabolite dehydrotestosterone (DHT). Like all st

Pathway Diagram:

Ariadne Genomics Inc. Ar chaperones Translocated Ar complex Ar target genes Ar coactivators Ar corepressors DHT testosterone Ar Translocated Ar complex ---> Ar target genes Ar ---> Translocated Ar complex Ar ---- DHT Ar ---- testosterone Ar coactivators ---- Translocated Ar complex Ar corepressors ---- Translocated Ar complex Ar ---- Ar chaperones testosterone biosynthetic pathway Ar corepressors ---| Translocated Ar complex Ar coactivators --+> Translocated Ar complex
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Genes in Pathway:

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androgen signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:2326084
G Carm1 coactivator-associated arginine methyltransferase 1 JBrowse link 8 22,577,723 22,622,555 RGD:2326123
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:2326123
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 JBrowse link 19 22,569,999 22,588,143 RGD:2326084
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:2326123
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:2326084
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:2326084
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link 8 44,989,401 44,993,261 RGD:2326084
G Ncoa1 nuclear receptor coactivator 1 JBrowse link 6 28,677,563 28,931,844 RGD:2326123
G Ncoa2 nuclear receptor coactivator 2 JBrowse link 5 5,466,544 5,696,540 RGD:2326123
G Ncoa3 nuclear receptor coactivator 3 JBrowse link 3 162,692,176 162,788,582 RGD:2326123
G Ncor1 nuclear receptor co-repressor 1 JBrowse link 10 48,629,121 48,772,890 RGD:2326123
G Ncor2 nuclear receptor co-repressor 2 JBrowse link 12 36,871,917 37,033,701 RGD:2326123
G Pias2 protein inhibitor of activated STAT, 2 JBrowse link 18 73,479,863 73,524,956 RGD:70792
G Prmt1 protein arginine methyltransferase 1 JBrowse link 1 100,971,132 100,980,411 RGD:2326123
G St13 ST13, Hsp70 interacting protein JBrowse link 7 122,585,770 122,635,731 RGD:2326084
G Stip1 stress-induced phosphoprotein 1 JBrowse link 1 222,274,133 222,293,139 RGD:2326084
altered androgen signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:2326139
RGD:8693397
G Ncoa2 nuclear receptor coactivator 2 JBrowse link 5 5,466,544 5,696,540 RGD:8693397
G Ncor2 nuclear receptor co-repressor 2 JBrowse link 12 36,871,917 37,033,701 RGD:8693397

Altered Pathway:

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassAr chaperonesAndrogen receptor chaperones
Functional ClassAr coactivatorsAndrogen receptor coactivators
Functional ClassAr corepressorsAndrogen receptor corepressors
Gene GroupAr target genesAndrogen receptor target genes
Small MoleculeDHTdihydrotestosterone

Pathway Gene Annotations

Disease Annotations Associated with Genes in the androgen signaling pathway
Disease TermsGene Symbols
Abnormalities, MultipleCrebbp
Acute Coronary SyndromeHspa8
Acute Kidney InjuryAr , Hspa8
Acute-Phase ReactionNcor1
AdenocarcinomaHspa8 , Ncoa3
Adenocarcinoma of LungCrebbp , Ep300
Adenocarcinoma, ProstaticAr
Adenoma, Liver CellCarm1
AlopeciaAr
Alzheimer DiseaseCrebbp , Ep300 , Hsp90aa1
Amyotrophic Lateral Sclerosis 1Crebbp
Androgen-Insensitivity SyndromeAr
Anxiety DisordersNcor1
Arthritis, RheumatoidHsp90aa1
AsthmaCarm1 , Prmt1
AstrocytomaAr , Ncoa3
Attention Deficit Disorder with HyperactivityAr , Crebbp
Autistic DisorderAr
Bone NeoplasmsNcoa3
Brain IschemiaHspa8
Breast Cancer, FamilialNcor1
Breast NeoplasmsAr , Carm1 , Ep300 , Hsp90aa1 , Ncoa1 , Ncoa2 , Ncoa3 , Ncor1 , Ncor2
Breast Neoplasms, MaleAr
Bulbo-Spinal Atrophy, X-LinkedAr
Carcinoma, Adenoid CysticCrebbp , Ep300
Carcinoma, Ductal, BreastAr
Carcinoma, HepatocellularAr , Carm1 , Crebbp , Ep300
Carcinoma, Intraductal, NoninfiltratingAr
Carcinoma, Non-Small-Cell LungNcoa3
Carcinoma, Squamous CellCrebbp , Ep300 , Hspa8 , Ncoa3
Carcinoma, Squamous Cell of Head and NeckCrebbp , Ep300
Carcinoma, Transitional CellCrebbp , Ep300 , Ncor1
CardiomegalyEp300
CardiomyopathiesEp300
Clear-Cell Metastatic Renal Cell CarcinomaEp300
Colonic NeoplasmsEp300
Colorectal NeoplasmsCrebbp , Ep300 , Hspa8
Conduct DisorderAr
Coronary Artery DiseaseAr
Craniofacial AbnormalitiesEp300
CryptorchidismAr
Denys-Drash SyndromeAr
Dermatitis, ContactHsp90aa1
Diabetes Mellitus, ExperimentalAr , Ep300 , Hsp90aa1
Diabetes Mellitus, Type 2Ep300
Diabetes, GestationalAr
Diabetic NephropathiesEp300 , Hspa8 , Prmt1
Diabetic RetinopathyEp300
Drug-Induced Liver InjuryHspa8
Endometrial NeoplasmsAr , Ep300 , Ncoa1 , Ncor2
EndometriosisAr , Ncoa1 , Ncor1
EndotoxemiaEp300
Esophageal Squamous Cell CarcinomaCrebbp , Ep300
Fabry DiseaseAr
Frontotemporal Lobar DegenerationHsp90aa1
Genetic Diseases, InbornCrebbp
Genital Diseases, MaleAr
GlaucomaCrebbp
GlioblastomaCrebbp , Ncor1
GlomerulonephritisEp300
Glomerulonephritis, MembranoproliferativeEp300
Graft vs Host DiseaseHspa8
Heart ArrestEp300
Heart DiseasesEp300
Hernias, Diaphragmatic, CongenitalEp300
Hirschsprung Disease 1Crebbp
HirsutismEp300
HIV InfectionsHsp90aa1 , Hsp90ab1
Huntington DiseaseHspa8 , Ncor1
HyperalgesiaEp300
HypertensionAr , Ep300 , Hspa8
Hypertension, PortalHsp90aa1
Hypertension, RenalHspa8
HypospadiasAr
Hypospadias 1, X-LinkedAr
HypothyroidismNcoa1 , Ncor1
Hypoxia, BrainEp300
Infertility, FemaleAr , Hsp90ab1
Infertility, MaleAr
Inflammatory Bowel DiseasesHspa8
Insulin ResistanceAr
Intellectual DisabilityEp300
Ischemic Attack, TransientEp300 , Hspa8
Kidney Reperfusion InjuryEp300 , Hspa8
Lead Poisoning, Nervous SystemEp300
LeiomyomaAr
LeukemiaAr , Ncoa3
Leukemia, Myeloid, AcuteCrebbp , Ncoa2
Liver Cirrhosis, ExperimentalNcor2
Liver DiseasesDnaja2
Liver Failure, AcuteHspa8
Liver NeoplasmsCrebbp , Ncor1
Lymphoma, FollicularCrebbp
Lymphoma, Large-Cell, AnaplasticHsp90aa1
Lymphoma, T-CellEp300
Macular DegenerationHspa8
Mammary Neoplasms, ExperimentalNcoa1
MedulloblastomaCrebbp , Ep300
MelanomaCrebbp , Ep300 , Stip1
Metabolic DiseasesHspa8
MicrocephalyEp300
MicrognathismEp300
Mild Cognitive ImpairmentHsp90aa1
Mouth NeoplasmsHspa8
Multiple SclerosisHsp90ab1 , Hspa8
Multiple Sclerosis, Relapsing-RemittingHspa8
Muscle HypotoniaEp300
Muscular AtrophyHsp90ab1
Muscular Atrophy, SpinalAr
MyopiaEp300
Neoplasm MetastasisHsp90aa1 , Ncoa1
Neoplasm Recurrence, LocalAr
Neuropathy, PainfulEp300
ObesityAr , Ep300 , Ncoa3
Oppositional Defiant DisorderAr
Optic Nerve InjuriesEp300
OsteoarthritisNcor2
Osteoarthritis, KneeAr , Hsp90aa1
OsteoporosisAr
Osteoporosis, PostmenopausalAr
Osteoporotic FracturesAr
PancreatitisHsp90ab1
Paraneoplastic Syndromes, OcularHspa8
Parkinson DiseaseHspa8
Polycystic Ovary SyndromeAr , Ncor1
Precursor Cell Lymphoblastic Leukemia-LymphomaCrebbp
Pregnancy ComplicationsNcoa2
Prostate Cancer, FamilialAr
Prostatic HyperplasiaAr
Prostatic Intraepithelial NeoplasiaAr , Carm1
Prostatic NeoplasmsAr , Carm1 , Crebbp , Ep300 , Hsp90ab1 , Ncoa1 , Ncoa2 , Ncoa3 , Ncor2
Prostatic Neoplasms, Castration-ResistantAr
PsoriasisCarm1
Pulmonary FibrosisHsp90ab1
Reperfusion InjuryEp300 , Hspa8
Rubinstein-Taybi SyndromeCrebbp , Ep300
SarcopeniaAr
ScoliosisCrebbp
SepsisEp300
Sezary SyndromeCrebbp
Small Cell Lung CarcinomaCrebbp , Ep300
Spinal Cord InjuriesHsp90ab1
Spinocerebellar Ataxia 17Hspa8
Squamous Cell Carcinoma of the LungCrebbp , Ep300
Stevens-Johnson SyndromeEp300
Stomach NeoplasmsHspa8
Thumb DeformityCrebbp
Urinary Bladder NeoplasmsCrebbp , Ep300 , Ncor1
Uterine Cervical NeoplasmsCrebbp , Ep300 , Hspa8
Pathway Annotations Associated with Genes in the androgen signaling pathway
Pathway TermsGene Symbols
aldosterone signaling pathwayCrebbp , Hsp90aa1 , Hsp90ab1 , Ncoa1 , Ncoa2 , Ncor1 , Ncor2
altered androgen signaling pathwayAr , Ncoa2 , Ncor2
androgen signaling pathwayAr , Carm1 , Crebbp , Dnaja2 , Ep300 , Hsp90aa1 , Hsp90ab1 , Hspa8 , Ncoa1 , Ncoa2 , Ncoa3 , Ncor1 , Ncor2 , Pias2 , Prmt1 , St13 , Stip1
antigen processing and presentation pathwayHsp90aa1 , Hsp90ab1 , Hspa8
cell cycle pathway, mitoticCrebbp , Ep300
chaperone mediated autophagy pathwayHsp90aa1 , Hspa8 , St13 , Stip1
clathrin-dependent synaptic vesicle endocytosisHspa8
cortisol signaling pathwayCrebbp , Dnaja2 , Ep300 , Hsp90aa1 , Hsp90ab1 , Ncoa1 , Ncoa2 , Ncoa3 , Ncor1 , Ncor2 , Stip1
endocytosis pathwayHspa8
Endoplasmic Reticulum-associated degradation pathwayDnaja2 , Hsp90aa1 , Hsp90ab1 , Hspa8
epidermal growth factor/neuregulin signaling pathwayHsp90aa1
estrogen signaling pathwayCarm1 , Crebbp , Dnaja2 , Ep300 , Hsp90aa1 , Hsp90ab1 , Ncoa1 , Ncoa2 , Ncoa3 , Ncor1 , Ncor2 , Prmt1 , Stip1
forkhead class A signaling pathwayAr , Crebbp , Ep300 , Ncoa3
Hedgehog signaling pathwayCrebbp
hepatitis C virus infection pathwayPias2
histone modification pathwayCarm1 , Crebbp , Ep300 , Prmt1
homocysteine metabolic pathwayCarm1 , Prmt1
Huntington disease pathwayCrebbp , Ep300
hypoxia inducible factor pathwayCrebbp , Ep300 , Ncoa1 , Ncoa2
influenza A virus infection pathwayCrebbp , Ep300 , Hspa8
Jak-Stat signaling pathwayCrebbp , Ep300 , Pias2
long term potentiationCrebbp , Ep300
measles infection pathwayHspa8
methionine cycle/metabolic pathwayCarm1 , Prmt1
mitogen activated protein kinase signaling pathwayHspa8
Mycobacterium tuberculosis infection pathwayCrebbp , Ep300
NOD-like receptor signaling pathwayHsp90aa1 , Hsp90ab1
Notch signaling pathwayCrebbp , Ep300 , Ncor1 , Ncor2
nuclear factor, erythroid 2 like 2 signaling pathwayCrebbp , Ncoa3
p53 signaling pathwayCrebbp , Ep300
phosphatidylinositol 3-kinase class I signaling pathwayHsp90aa1
phosphatidylinositol 3-kinase-Akt signaling pathwayHsp90aa1
prednisolone pharmacodynamics pathwayHsp90aa1
prednisolone pharmacokinetics pathwayHsp90aa1
prion diseases pathwayStip1
prostate cancer pathwayAr , Crebbp , Ep300 , Hsp90aa1 , Hsp90ab1 , Ncoa2 , Ncor2
protein kinase C (PKC) signaling pathwayHsp90aa1
renal cell cancer pathwayCrebbp , Ep300
retinoic acid signaling pathwayNcoa1 , Ncoa2 , Ncoa3 , Ncor1 , Ncor2
RNA polymerase I transcription pathwayCrebbp
small cell lung cancer pathwayPias2
spinobulbar muscular atrophy disease pathwayAr
spliceosome pathwayHspa8
tamoxifen pharmacodynamics pathwayNcoa3 , Ncor1 , Ncor2
Toxoplasma gondii infection pathwayHspa8
transforming growth factor-beta Smad dependent signaling pathwayCrebbp
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Ep300
type II interferon signaling pathwayCrebbp , Ep300
ubiquitin/proteasome degradation pathwayPias2
vascular endothelial growth factor signaling pathwayHsp90aa1 , Hsp90ab1
Wnt signaling pathwayCrebbp , Ep300
Wnt signaling, canonical pathwayCrebbp
Phenotype Annotations Associated with Genes in the androgen signaling pathway

References Associated with the androgen signaling pathway:

Ontology Path Diagram:

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