PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: tamoxifen pharmacodynamics pathway
Accession: PW:0000839
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Definition: The pathway of tamoxifen-target interaction and of the biochemical or physiological responses to drug. In breast cancer cells, tamoxifen binding antagonizes estrogen binding and the subsequent conformational changes necessary for co-activators recruitment. It may also prompt the recruitment of co-repressor. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms: related_synonym: SMP:00471
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
ISO
SMPDB
SMP:00471
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
ISO
SMPDB
SMP:00471
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
ISO
SMPDB
SMP:00471
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
ISO
SMPDB
SMP:00471
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Esr1
estrogen receptor 1
ISO
SMPDB RGD
PMID:19629072
SMP:00471, RGD:5130191
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
ISO
RGD
PMID:19629072
RGD:5130191
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Fmo1
flavin containing dimethylaniline monoxygenase 1
ISO
SMPDB
SMP:00471
NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
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Fmo3
flavin containing dimethylaniline monoxygenase 3
ISO
SMPDB
SMP:00471
NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
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Ncoa3
nuclear receptor coactivator 3
ISO
RGD
PMID:16822624
RGD:5130718
NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594
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Ncor1
nuclear receptor co-repressor 1
ISO
RGD
PMID:16822624
RGD:5130718
NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032
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Ncor2
nuclear receptor co-repressor 2
ISO
RGD
PMID:16822624
RGD:5130718
NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319
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Phb2
prohibitin 2
ISO
RGD
PMID:16822624
RGD:5130718
NCBI chr 4:157,517,662...157,522,268
Ensembl chr 4:157,517,577...157,522,272
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Sult1a1
sulfotransferase family 1A member 1
ISO
SMPDB
SMP:00471
NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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Ugt1a5
UDP glucuronosyltransferase family 1 member A5
ISO
SMPDB
SMP:00471
NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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